AMiNDR: A Month in Neurodegenerative Disease Research

Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis!   Clinical Studies (3:53) Preclinical Studies/Methology (12:41)    --------------------------------------------------------------   To find the numb...

Anusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopeful about future therapeutic directions!   Drug Disc...

In this exciting episode, Judy goes over papers published in May 2022 on the latest research involving cognitive, behavioural and clinical changes in AD. Subjects include sensory processing, mouse models, sleep, and many more!     Sensory Processing (1:45) Mouse Models (5:44) Clinical Treatments (8:34) Sleep (12:59) Other (17:29)   --------------------------------------------------------------   T...

In this episode, Joseph is back to go over papers published in May 2022 on GWASs, genetics or any other genetics-focused work. Topics include GWAS's, tool development, gene discovery, and social performance-based genetic studies!   GWAS and Polygenic Risk Scores (2:20) Cognitive & Social Genetic Studies (8:42) Tool development (11:46) Gene Discovery (14:41) Studies on Amyloid and Tau (16:09)   ---...

Welcome welcome! This episode was made for you if you are interested in geriatrics, neurology, or cognitive testing in general, as we will go through the latest publication on clinical assessment of cognitive decline. That’s right, 9 papers published in May 2022 on testing neurocognitive domains for the screening or diagnosis of mild cognitive impairment, Alzheimer’s disease, or dementia in genera...

AMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join her if your neurons are excited by the topic!   ...

In the final episode of the March 2022 series, Naila takes you through 18 papers on non-pharmacological strategies for preventing or treating Alzheimer's disease. You'll hear the latest from animal studies on exercise, learn about the potential benefits of brown rice, pet ownership and yoga, and be guided through a number of techniques that are being used to modulate brain activity with the hopes...

Welcome back for the second of a 2-part episode on the clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! You will hear about the evaluation of traditional and digital tests for their potential to help us detect AD and distinguish it from MCI. Also on the menu, a few papers on markers of cognitive decline that may help us refine our diagnosis, or even for progn...

This is our monthly update on clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! This is the first of a 2-part series on the matter, where we bring together ways to assess cognitive function by looking at one neurocognitive domain, such as learning and memory, language, perceptual-motor skills, and even by looking at activities of daily living. This is perfect...

Another 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too?   Sections in this episode:   Stem Cell-Based Therapy (...

Ease in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too!   Sections in this episode:   Synaptic Connectivity Changes (1.44)   APP/Tau contribution to Synaptic Dysfunction (7...

In February of 2022, 8 papers were published on the topic of using neuroprotective compounds as treatment for AD. Anusha will guide you through these papers exploring the entire drug discovery pipeline, from discovery to clinical trials.   Sections in this episode:   Drug Discovery (2.01)   Drug Development (4.59)   Clinical Trials (11.58)  ---------------------------------------------------------...

February 2022 was full of abstracts using unique therapeutic approaches to target Alzheimer's disease. Cassi presents abstracts on both naturally-occurring and pharmaceutical compounds used to treat various neurodegenerative pathology and symptoms.   Sections in this episode:   Microbiome (1:55)   NF-kappaB signaling pathway (6:12)   Sexual dimorphism (11:34)   Naturally-occurring & pharmaceutical...

In today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in our show notes or at www.amindr.com!   Sections in t...

Welcome back for the continuation of our segment on clinical assessment. You heard about testing specific neurocognitive domains in part 1, and here we’re back to cover abstracts that look at the big picture in assessing cognitive function. We’re presenting 8 abstracts published in February 2022, perfect for you if you’re interested in tracking cognitive decline for the diagnosis of Alzheimer’s di...

If you wanted to detect and diagnose Alzheimer’s disease, or assess disease progression, what aspects of cognition would you focus on? In other words, what capabilities would you test to decide if someone is indeed experiencing cognitive decline, had Alzheimer’s disease, or another type of dementia? And what tools could you use? Stay with me to hear about the abstracts dedicated to specific cognit...

This month's episode covers a range of interventions and non-pharmacological treatments that could help prevent or live with AD. Naila will take you through the various mechanisms underlying the impact of different lifestyle interventions, the potential therapeutic effects of exercise, what mushroom consumption and ketogenic diets might have to offer, and plenty of other stimulating topics!   Sect...

Ever wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their phenotype? Well, you've come to the right place. Elyn will take you through all this and more as she emphasizes the importance of cerebrovascular health in the context of Alzheimer disease in this episode c...

In Part 2 of epidemiological studies published in January 2022, we'll focus on the association between cardiovascular health, diabetes and Alzheimer's disease. Naila will guide you through the latest research on how things like blood pressure, body mass index and insulin resistance are related to dementia and to AD pathology.   Sections in this episode:   Cardiovascular Factors (2:35)   BMI (12:25...

In Part 1 of this 2-part episode on epidemiological studies published in January 2022, Naila will take you through 12 papers on risk and protective factors linked to Alzheimer's disease, ranging from stressful life events, to exposure to greenspace in one's neighborhood, to sleep troubles and testosterone. We cover a lot of ground in this episode, and if you want to cover even more, look out for P...

With her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this and much more in this longer episode covering 15 papers published in January 2022!   Sections in this episode:   Clinical Insights - Vascular Risk Factors (3:46)   Blood-Brain Barrier Dysfunction (9:41...

Pssst. Did you hear that 14 papers were published in January of 2022 on treatments targeting synaptic and neuronal protection in Alzheimer's disease? Anusha has you covered with papers targeting amyloid-beta-induced cytotoxocity, demyelination, and cognitive dysfunction in animal models.   Sections in this episode:   Treatments using stem cells (2.18)   Protecting against A-beta induced toxicity (...

What information do grey and white matter tell us about mild cognitive impairment vs. Alzheimer's disease? Enjoy this episode in which Christy goes over study findings from 12 papers published in January 2022 on the topic of structural brain changes related to AD.   Sections in this episode:   Gray and white matter changes (2.25)   Correlations of structural changes with biomarkers (9.28)   Method...

Today's episode will take you all the way from the molecular to the human level in 16 papers on non-pharmacological approaches for preventing or treating Alzheimer's disease. Naila will guide you through the latest research on exercise in AD mouse models, nutritional supplements that could decrease the risk of AD, the potential therapeutic effects of repetitive transcranial magnetic stimulation, a...

We start off our January 2022 series of AMiNDR with this episode highlighting 9 papers on changes to synaptic transmission in Alzheimer's Disease. In this episode, Anusha will cover topics including changes to GABAergic and glutamatergic transmission and calcium flux in AD-affected neurons. We also have papers looking at age-dependent changes in synaptic function in AD. End neuro -transmission ;) ...