What's Your Problem?

David Autor is a labor economist at MIT. He has written about how the arrival of personal computers increased inequality among American workers. But when it comes to AI, David thinks there could be a different outcome.  Read David’s article about AI in Noema Magazine .  In this episode, David explains:  How computers increased the wage gap between college and non-college educa...

John Mills is the CEO and co-founder of a nonprofit called Watch Duty. His problem is this: How do you build an app to warn people when they are in immediate danger from a natural disaster? Watch Duty has millions of users and played a key role in the Los Angeles fires of 2025. In the show, John talks about how he built his app with the help of an army of volunteers, and why the government hadn&rs...

Josh Tyrangiel is the author of “ AI for Good: How Real People Are Using Artificial Intelligence to Fix Things That Matter .” On today’s show, Josh talks about some of these real people and the problems they’re working on: a professor trying to understand her nonverbal son, a general who delivered millions of Covid vaccines in 2021, and a hospital CEO trying to reduce the r...

Betsey Stevenson is a labor economist at the University of Michigan, and she was an economic adviser to President Obama. Betsey’s problem is this: How can we create a world where the benefits of AI are broadly shared? Betsey draws on history – including how the invention of household appliances created a crisis of meaning for American women – to understand how we should respond t...

Maps have gotten much better over the past few decades. But they're still mostly two dimensional, and they struggle to keep up with a world that is always changing. Brian McClendon is the Chief Technology Officer of Niantic Spatial, a spinout of the company that makes Pokémon Go. Brian's problem is this: How do you build a three-dimensional map of the world that both robots and humans can u...

Dan Shipper is the co-founder and CEO of Every, a company that publishes newsletters about AI, develops AI-related software, and helps other companies use AI. Dan has two problems. One, how do you build a company where almost everybody has their own AI agent? And two, how do you use AI as a tool to improve your writing, rather than as a replacement for writing? In this episode, Dan explains: ...

The apples you can buy at the grocery store have gotten profoundly better over the past few decades. It’s a kind of everyday, hiding-in-plain sight innovation.  Kate Evans is an apple breeder and professor at Washington State University. Kate's problem is this: How do you invent a better apple? With her team, Kate has in fact invented a new kind of apple called the Sunflare. It’s arriv...

Rob Meyerson is the co-founder and CEO of Interlune. Rob's problem is this: How do you help build an economy on the moon? Eventually, Rob hopes Interlune will help build a moon base. For now, he is focused on bringing a gas called helium-3 back from the moon to sell on earth.  Earlier in his career, Rob was the president of Blue Origin, the rocket company founded by Jeff Bezos. In this episod...

Aaron Edsinger left his job as director of robotics at Google to start a company called Hello Robot. Aaron’s problem is this: How do you build an affordable robot that people can use to solve real problems at home? The result is a robot that looks nothing like a person. In fact, it’s closer to a Roomba with an arm. In this episode, Aaron explains:   Why home robots have barely pro...

Ben Christensen is the co-founder and CEO of Cambium, the largest seller of salvaged wood in America. Ben's problem is this: How can we turn the trees that are falling to the ground all around us, into usable wood? In this episode, Ben explains:  Why so much wood goes unused  Why Cambium created demand before building the supply chain  How building a data layer across the fragmented...

Investors are pouring billions of dollars into nuclear fusion companies. The dream: transform human civilization (and power AI data centers) by providing cheap, abundant energy. But nobody’s figured out how to make it work yet. What will it take to make fusion work at scale – and how will the world be different if it does? To answer this question, Jacob recently hosted a conversation a...

Mark Barrocas is the CEO of SharkNinja, a company that sells everything from vacuums, to blenders, to beauty products. Mark’s problem is this: How do you invent new products that people want to rave about on social media?  In this episode, Mark explains:  How SharkNinja finds product ideas The tradeoffs at the heart of product development How the Ninja Creami became a viral hit Why...

Michael Hufford is the co-founder and CEO of LyGenesis, a company working on a new treatment for end stage liver disease. Michael’s problem is this: How do grow a new liver inside the body of a sick patient? In this episode, Michael explains:  The liver's unique power of regeneration The organ transplant crisis and how regeneration can help  The science behind using lymph nodes to...

Rare earth elements are inside pretty much everything with an on-off switch: Phones, laptops, cars. Even missiles. And China controls the world’s supply of components made from rare earths. David Abraham is the author of the book “ The Elements of Power: Gadgets, Guns, and the Struggle for a Sustainable Future in the Rare Metal Age .” David’s problem is this: What should th...

Ben Bloom is the co-founder and CEO of Atom Computing, a company building quantum computers out of individual atoms. Ben’s problem is this: How do you build a quantum computer that is actually useful for everything from discovering new medicines to building better batteries?  In this episode, Ben explains:  The practical applications of quantum computers  Atom Computing’...

Jonny Dyer is the founder and CEO of a satellite company called Muon Space . The company’s first big project is a satellite constellation called FireSat. Jonny’s problem is this: How do you  capture data from space to help manage wildfires around the world in near-real time?  In this episode, Jonny explains: How smartphone tech inspired smaller, cheaper satellites. Why fighting wi...

After bacteria were discovered, it took scientists 200 years to figure out that they cause disease. If scientists had made the link sooner, hundreds of millions of lives could have been saved.  In his recent book So Very Small, Tom Levenson, a professor of science writing at MIT, tells the amazing story of germ theory, and argues that our worldview can prevent us from seeing what is right in...

Evan Ratliff co-founded a publishing startup in 2011. Now he hosts a podcast called Shell Game. In the latest season of the show, Evan creates a company run by AI agents. The project is absurdly funny – Evan calls it an office satire – but it also illuminates the power and limits of AI agents. See omnystudio.com/listener for privacy information.

Patrick Hsu is the co-founder of Arc Institute, which is integrating AI models and biological research. Patrick’s problem is this: How can you use AI to make biological research more efficient – and ultimately to find cures for Alzheimer’s and other complex diseases? See omnystudio.com/listener for privacy information.

In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to prevent heart attacks. Eric Topol is a cardiologist and the founder of the Scripps Research Translational Institute in San Diego. Eric’s problem is this: How can doctors use recent technological developments to do a better job at preventing heart...

Samir Ibrahim is the co-founder and CEO of SunCulture. When he started the company, he thought he was solving a simple problem: How do you sell solar-powered pumps to help poor farmers irrigate their land? It turned out, he was working on something much bigger: How do you help poor farmers get richer, and create a giant new market from scratch? See omnystudio.com/listener for privacy information.

Nabiha Saklayen is the co-founder and CEO of Cellino. Nabiha’s problem is this: How can you make personalized stem cell therapies quickly and cheaply?  Induced pluripotent stem cells, or IPSCs, have shown tremendous promise as treatments for illnesses like Parkinson’s, leukemia, and heart disease. On today’s show, Nabiha explains why IPSC manufacturing is still mostly done by han...

Please take our survey https://tinyurl.com/wyplistenersurvey  about the show! Tell us what you want to hear, and what would make it better. Tim Bucher is a farmer, and the founder and CEO of Agtonomy. Tim's problem is this: How do you build an autonomous tractor that can work for specialty crops like grapes, olives, apples, and almonds?  On today’s show, Tim explains what makes cer...

Mitch Lee is the co-founder and CEO of Arc Boats. Mitch's problem is this: How do you build competitively priced electric boats? On today’s show, Mitch explains why water makes electrification so hard, the techno-economic puzzle of building giant battery packs, and how Arc’s high-end wake sport boat opened the door for a new generation of hybrid-electric tugboats. See omnystudio.com/li...

Nina Mohanty is the founder and CEO of Bloom Money. Nina’s problem is this: How do you build an app to help immigrants manage their money? On today’s show, Nina talks about bringing a saving and lending practice into the 21st century, navigating regulators who’ve never seen anything like it, and what global traditions can teach us about the future of money. See omnystudio.com/lis...