Ryan Sprague
This One Time On Psychedelics
Welcome, fellow explorers of the infinite. If you’re here, it means you’re ready to step beyond the ordinary and into the great unfolding mystery of existence itself. Because psychedelics? They’re not just substances—they’re a doorway to a new way of seeing reality, a lens that reveals the hidden layers of reality we walk through every day. And that’s exactly what we explore here. I’m Ryan Sprague, and This One Time On Psychedelics isn’t just about trippy stories and wild journeys (though trust me, we have plenty of those). It’s about the conversations that hold the power to awaken us, to shif...
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Ep. 213: It’s Not Goodbye, It’s See Ya Later! (feat. Rachel Varitimos) 25.04.2025 53:16
Alrighty guys, this episode is extra special to my heart because it’s officially my last episode (for now) on this show before I transition back to the Highly Optimized podcast, my first project that was birthed in 2019 when I chose to start paving my own path, leave my job & go into the unknown. To say the last 3 years of doing this show has been magical, exciting & heart warming would be...
Ep. 212: The Trifecta Of MDMA, Psilocybin & Intramuscular Ketamine (feat. Adam Schell) 18.04.2025 1:04:11
One of the main reasons I started this podcast was to showcase the stories, experiences & impact these medicines have made upon people’s lives. That being said, I still get goosebumps when I hear those stories as they remind me of the immense power that not only these medicines hold within them, but that we also hold within us. Todays guest on the show is a returning guest, one of my dear brot...
Ep. 211: Adventures In Decentralization & Why This Movement Excites Me SO Much (feat. Amethyst Flame) 11.04.2025 1:02:34
For anyone with eyes to see, it’s no secret the world is changing at a rapid rate these days. From political hysteria, to new technology emerging almost daily, it’s safe to say that it’s easier than ever to feel overwhelmed while simultaneously doing your best to keep up. In my opinion, one of the most important & powerful aspects of the new world that we can take the initiative to dive into i...
Ep 210: How The 2018 Farm Bill *Accidentally* Legalized Cannabis (feat. Rand Gifford) 04.04.2025 1:11:38
Every episode I do I am excited about, however, this one holds a special place in my heart for a few reasons. First, anytime I get to speak with someone who is as passionate as I am around regenerative agriculture, I geek out like a small school child. This being said, when I get to speak to someone who not only shares that passion, but is creating revolutionary products alongside it that ANYONE i...
Ep. 209: An In Depth Look At How Astrology Has Changed My Life (feat. Rachel Varitimos) 28.03.2025 1:05:26
Whenever I have the opportunity to do a podcast with the love of my life, I jump at the opportunity & this week’s episode is no different. Many of you love the episodes here & I do together & our intention with todays episode is to give you a window into our personal life, what astrological shifts have been taking place over the past 3 months, how these shifts have manifested in our li...
Ep. 208: Psychedelic Experiences, Presence & What Really Matters In Life (feat. Seibo Shen) 21.03.2025 59:35
One of the main reasons I love podcasting so much is, yep, you guessed it, I adore speaking, however, speaking to myself alone in a room is a little weird & definitely not the same experience as when I get to speak to others who stimulate my curiosity, peak my inspiration & remind me of how epic & infinite life can be. As such, this show has become a zone of excitement & growth for...
Ep. 207: You Don’t Need A Guru: Here’s How To Heal Yourself (feat. Christopher August) 14.03.2025 40:04
Whenever today’s guest & I get together, I know it’s going to be an epic conversation. From working together the last two years creating the Breathe With Cannabis brand that many of you have attended already, to traveling to epic places together, creating memories & more, to say I am grateful for his presence in my life would be an understatement. As such, him & I were talking recently...
Ep. 206: Opening Up To A Brand New World Through Psychedelic Medicines (feat. Kyle Langan) 07.03.2025 1:07:05
One of, if not my favorite types of stories I enjoy hearing from the psychedelic space are the stories that come from individuals who, at one point, did not resonate with psychedelic medicines at all. You guys have heard me say before & I’ll say it again that for me, I never judge anyone who is opposed or not interested in psychedelic medicines because the truth is nothing is for everybody, ho...
Ep. 205: The Mysteries Of 12 Strand DNA Decoded (feat. Dr. Samuel Lee) 28.02.2025 1:02:54
I am sure you guys know what I mean when I say that sometimes I find someone new out there in the world & just cannot get enough of their content & perspective of the world. For me, I take these types of experiences as signs. Signs that perhaps we knew each other in a previous lifetime, signs that obviously something within what they’re teaching is resonating with me on a deep level &...
Ep. 204: Utilizing Psychedelics In The Grieving Process To Heal (feat. Mia Cosco) 21.02.2025 1:12:26
One of the areas within the psychedelic space that is extremely important, yet often overlooked, is the ability for these medicines to assist in the process of grief. Grief is something that all of us, no matter what background, ethnicity or age group, go through from time to time. This being said, grief is also one of the main challenges that many of us have never learned how to deal with & a...
Ep 203: Demystifying The World Of Ayurveda (feat. Ivette Desai) 14.02.2025 58:30
Chances are this isn’t the first time you’re hearing the term “Ayurveda”. For those of us who identify as spiritual seekers, the world of ayurveda is one we hear of often & already practice to some degree in our lives (where my shilajit lovers at?”. However, I know for me, that although I knew a *little* about ayurveda, I had long been fascinated with the topic & had wanted to learn more....
Ep. 202: Exploring Quantum Shifts & Synchronistic Moments (feat. Shawna Pelton) 07.02.2025 1:08:53
Sometimes in life, I meet people that just feel like a breath of fresh air in my life. It’s hard to put into words what I mean by that, but for those of you who have experienced this notion, I imagine you know exactly what I mean & todays guest is a woman who I can confidently say has done that each time I have connected with her. She is a trauma informed psychedelic advocate & medicine wo...
Ep. 201: Journeys In Psil-osophy, Hermetics & Psychedelica (feat. Austin West) 31.01.2025 1:09:15
As you guys may have heard on my episode 200 solo cast last week, my favorite part of this podcast is meeting individuals that once I meet, I truly have no idea how I’ve gone my whole life not knowing. The truth is that the relationships in our life are designed to act as mirrors, allowing us to see the beauty in individuality & also to see ourselves in ways we otherwise couldn’t. Today’s gues...
Ep. 200: What A Journey It’s Been… 24.01.2025 1:02:51
Wow guys…what a journey it’s been. It’s hard to believe that this podcast is already at episode 200, but, like they say, time flies when you’re having fun. In this episode, I decided to do something I’ve only done once before & do a solo cast where you guys can hear more of how this journey has been for me, the challenges I’ve experienced along the way, some of my favorite aspects & memori...
Episode 199: The Psychedelic Frontier: Navigating Entrepreneurship & Safety (feat. Matthew Ritchey) 17.01.2025 1:21:31
The emerging world of psychedelic medicines, accompanied by the ancillary industries associated with them, is bringing with it a LOT of opportunities. For me, being as how I grew up in the world not generally interested in most of what other people did, I have long been excited at the thought of new industry emerging that can do its part in shaking up the typical way we’ve been taught life has to...
Ep. 198: Opening Up To More Magic & Purpose Through Psychedelic Medicines (feat. Sofiya Skakri) 10.01.2025 1:09:15
Each time I have the opportunity to do a podcast with someone who fills my heart up with joy & inspires me to dig deeper into my mission I have a blast. This being said, todays guest on the show is a woman who although I only met recently, has become a fast friend of mine & in that, we’ve found a lot of commonality in what we love & how we serve in the world. From her intro into psyche...
Ep. 197: How Psychedelics, Hypnosis & Biohacking Can Help You Create The Life Of Your Dreams (feat. Elia Bean) 03.01.2025 1:08:20
For any of us that love psychedelic medicines, one thing that quickly becomes apparent is their ability to rapidly transform our mental landscape, including shifting belief systems, architecting new stories for us to live life through & ultimately allowing us to wake up to the truth of who & what we are as divine beings living out a human experience. That being said, we can’t necessarily c...
Ep. 196: Combining The Powers Of Cannabis & Tantra (feat. Zipporah “The High Priestess” Gongora) 27.12.2024 1:14:11
I am fortunate enough in my life to be able to do what I love each day of my life & a BIG part of that is the love I have for podcasting. As such, I truly love & deeply enjoy all the episodes I get to do & have a blast connecting with new people, however, some episodes just touch my heart in ways that are extra special & todays episode is an example of that. Todays guest on the sho...
Ep. 195: How Psychedelics Can Make You A Better Entrepreneur (feat. Ani Manian) 20.12.2024 1:20:42
One of the things that most people who do not utilize psychedelic medicines in their life would not immediately see a link between is how psychedelics can allow us to become better business owners & leaders, however, in my opinion, these things being linked together make SO much sense, as has been the case for me, because they allow for an expanded look at one’s life & as such, they can al...
Ep. 194: Tales From The Water Shaman Himself (feat. Samson “The Water Shaman” Luce) 13.12.2024 1:04:13
You guys know that feeling you get when you meet someone who makes you feel more safe knowing they’re walking the planet the same time you are? This is the exact feeling I got when I originally met the guest for today’s episode. This man is someone who is SO full of love, joy, magic & FUN that it is immediately apparent to anyone fortunate enough to cross paths with him & I am forever grat...
Ep. 193: Master Your Breath, Transform Your Life (feat. Christopher August) 06.12.2024 59:42
If there is one modality aside from psychedelic medicines that has assisted me immensely over the last decade of my life, it is breathwork. From all the varying styles available to us to the fact that no matter who we are or where we are in the world that we always have access to our breath, I truly feel that breathwork is the perfect bridge to bridge the gap between the regular world we live in e...
Ep. 192: How Psychedelics Can Help You Be A Good Steward For Planet Earth (feat. JR “The Bear” Hendry) 29.11.2024 1:21:23
After many years of podcasting, coaching & otherwise talking non stop, I’ve truly come to realize, understand & appreciate the art of conversation. When I meet individuals who I can have an off the cuff, pure flow state deep dive with, my heart lights up more than almost any other scenario in life & when you combine that with somebody who can speak so eloquently to relevant realms to w...
Ep 191: From Wall Street To Psychedelics, Spirituality & More (feat. Jason Pickard) 22.11.2024 1:14:12
Every once in a while in my life, I meet someone who as soon as I meet, I wonder how in the hell I ever lived my life without them in it. Typically, these people are people that I feel an instant connection with & who, along with many other facets, really spark my curiosity, inspiration & spiritual buttons in ways which open me up to new possibilities in life. Today’s guest on the show fit...
Ep. 190: The Complete Deep Dive Into Cannabis Genetics (feat. Joe Colletta & Patrick) 15.11.2024 1:12:39
The world of Cannabis genetics today looks much different than it did even just 5 years ago. With more & more breeders coming forth & more strain selection than ever, I find many people are confused on how to navigate this world & be able to truly understand how to find high quality genetics. Today’s guests on the show are two men who are looking to create the new standard when it come...
Ep. 189: Finding Strength, Courage & Love Through Psychedelics & Sound Healing (feat. Shelley DeMarco) 08.11.2024 1:05:11
In the current psychedelic renaissance, many people who otherwise had never been interested in psychedelic medicines are now finding interest in working with them. Whether it’s through the mainstream, the self development/spiritual industries or otherwise, it’s clear that with this many people with little to no prior experience now entering this realm, that the necessity for proper training &...
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