The Human Upgrade: Biohacking for Longevity & Performance

On today's episode, Jerry Colonna shares his transformative journey from a high-powered venture capitalist to a Buddhist coach. You'll learn about the profound impact of “radical self-inquiry" on leadership and life, illustrating how deep personal development can reshape personal and professional relationships. You'll also learn how mindfulness and self-awareness are crucial for effective leadersh...

Today on The Human Upgrade, Dr. Anurag Singh, a renowned expert in muscle biology and aging, shares his expertise on the impact of GLP-1 agonists like Ozempic and Wegovy on weight loss, muscle health, and aging. In this episode, you'll learn about the science behind these popular drugs, their potential benefits, and the risks involved. Discover how you can maintain muscle mass while losing weight,...

Today's episode focuses on Cancer with a true expert, Mark Lintern. You'll learn about the surprising links between infections, inflammation, and our body's powerhouses - the mitochondria. This is a chance to arm yourself with cutting-edge theories that could change the way we treat cancer. Simple changes in treatment perspectives might be the key to unlocking new ways to tackle cancer and by the...

Get ready for a journey that takes you beyond the pain of heartbreak and into a world where loss transforms into growth with science journalist Florence Williams, who shares her personal triumph over the heartbreak of divorce, which inspired her to write a book on the subject. This episode sheds light on how heartbreak reshapes our bodies and minds. You'll gain valuable tactics for emotional...

Managing your stress effectively and building resilience just got easier with Dr. Aditi Nerurkar's guidance on The Human Upgrade. This episode tackles 'toxic resilience,' revealing its impacts on health and well-being. You'll gain insights into the HPA axis—the body's command center for stress response—and learn practical techniques to turn stress into a growth tool. Dr. Aditi introduces the 'Rule...

In this special Asprey Archive episode you’ll learn that while yes, testosterone fuels energy and performance, it’s not the be-all and end-all solution for men’s health woes. A systems biology approach considers many other aspects and provides a broader perspective about what’s going on with you. This conversation features board-certified urologist   Tracy Gapin, M.D.  He joined us...

In today’s episode you’ll explore the complexities of memory with Dr. Charan Ranganath, a top expert in cognitive neuroscience. This episode takes you through the fascinating ways our brains record, process, and utilize memories to navigate daily life and shape our futures. You’ll learn how memory impacts decision-making, the truth about common myths, and the role of groundbreaking research in our...

Join Dave Asprey for a fascinating discussion with Colleen Cutcliffe, Ph. D., on leveraging the power of GLP-1 for natural weight management and overall well-being. Discover how probiotics can naturally stimulate GLP-1 production in the body, helping reduce food cravings and maintain a healthy gut lining. We delve into the differences between pharmaceuticals and natural probiotics, the importance...

Today you'll step inside the real world of fame with Ramon Hervey II, the mastermind manager behind iconic figures like Vanessa Williams, Bette Midler, and Richard Pryor. He is author of "The Fame Game: An Insider's Playbook for Earning Your 15 Minutes." With years of experience guiding celebrity journeys, Ramon dismantles the myths surrounding fame and success. In this episode, he shares invaluab...

Today you’ll learn about female hormones: what they are, what they do, and what disrupts them. You’ll learn about the hormonal shifts that happen at different ages and life stages and get tips on how to balance hormones and make them work  for  you, not against you. This conversation features  Anna Cabeca, D.O. .   Dr. Anna is a Doctor of Osteopathy who’s triple-board certified...

What if you could catch cancer in its earliest stages, when it's most treatable—would you seize that chance? Our guest today is Dr. Josh Ofman, the president of GRAIL, and he's pioneering early cancer detection in a revolutionary new way. You'll discover the cutting-edge advances in multi-cancer early detection that are transforming the fight against this swift and silent killer. You'll also learn...

I had the pleasure of talking with Dr. Christina Rahm, who has an inspiring journey from a pharmaceutical executive to an advocate for integrating holistic health solutions with rigorous scientific methods. We dive into the impact of spirituality on wellness, the transformative power of neural feedback, and the intersection of technology and ethics in health. Dr. Rahm shares her insights into comb...

In this profound episode, Maria Menounos shares her journey through significant health challenges, including a brain tumor and diabetes, and how she emerged more resilient and health focused. Renowned for her vibrant career in entertainment and now as a wellness advocate, Maria delves into the transformative power of facing mortality, redefining medicine, and leveraging biohacking to enhance her l...

Today, Calley Means joins the show to march onward on his war path to changing the incentives of modern health. He’s a champion of food and lifestyle practices as medicine—and, in May of this year, he’s putting out a new book on the subject which we outline today, called Good Energy. His sister, Dr. Casey Means, is the co-author of Good Energy. You know her from a past appearance on this show and...

How can we make our furry best friends live longer, healthier lives? A true pioneer in this field, Dr. Matt Kaeberlein, is here to unpack this important subject while highlighting the crossover between human and canine longevity. You read that right; this episode isn't just for dog lovers—it's a deep dive into longevity for humans, too.  Dr. Matt Kaeberlein, who's the CEO of Optispan and a ke...

I’m excited to welcome back Jewels Arnes, an author, ascension coach, and the founder of BioQuantum Skincare Technology. Jewels has more than 30 years of experience in energy medicine and intensive consciousness work.  In today’s episode, Jewels explains scalar waves, ORMUS, and the quantum level. She shares how these concepts all contribute to her BioQuantum Skincare line and the intention s...

What is the role of Ego? Is AI going to kill us? Is there hope for the future of our species? These are just a few of the big questions you’ll tackle in today’s enlightening and esoteric episode. I’m joined by Teal Swan, a thought leader, bestselling author, and international speaker who is on a mission to reduce human suffering. After a challenging upbringing, Teal emerged with a unique ability t...

Today’s guest is none other than Shawn Stevenson. If you’re not already familiar with Shawn’s work, he’s the author of the USA Today National bestseller Eat Smarter, the international bestselling book Sleep Smarter, and the creator of the widely popular health podcast, The Model Health Show. Shawn is one of those guys who embodies peace and calm, after an impressively transformative journey stemmi...

Today’s guest has the coolest title I’ve ever heard—mind architect.  Peter Crone is a world-renowned spiritual teacher, mind-body wellness coach, and life transformation expert. He’s worked with everyone from athletes, to actors, to billionaire CEOs, to everyday people trying to do their best. Peter helps people achieve spiritual freedom, mental peace, and physical vitality, which all align w...

Today, we're diving into a topic that's on everyone's mind, but often misunderstood: gluten. Joining the show on this gluten-decoding mission is none other than Dr. Peter Osborne, aka the Gluten-Free Warrior. Dr. Osborne is a powerhouse of knowledge in nutritional health, particularly regarding gluten sensitivity and food allergies.  As the founder of Gluten Free Society, the author of the be...

Today we’re talking about something a little different—the “weird,” esoteric, metaphysical stuff. I’m joined by Laura Coe, who was a successful healthcare tech entrepreneur before selling her company and returning to her passion for philosophy. She is now an author, certified life coach, and Akashic Records reader.  Never heard of the Akashic Records? Laura explains exactly what they are, and...

Today I’m talking with one of the most sought-after celebrity trainers on the planet. Jason Walsh has trained stars like Matt Damon, Miles Teller, Brie Larson, and Bradley Cooper for some of the most physically demanding roles of their careers.  He’s also the founder of Rise Nation, a global fitness studio powered by the VersaClimber, where you train like an athlete.  On today’s episode,...

Blood sugar management as a biohack captures attention for its innovative approach to health. Today's guest, Jessie Inchauspé, stands out as an expert in guiding practical glucose management, smarter nutritional choices, and unveiling the intricate relationship between diet, blood sugar levels, and overall well-being. Behind the popular Instagram account @GlucoseGoddess, Jessie educates millions o...

Today we're talking about testosterone replacement and unpacking the novel concepts of progressive overload and variable resistance training—both methods to gain, and keep, muscle mass in your body without living in the gym. I’m joined by strength expert, entrepreneur, past guest of the show, and PhD, John Jaquish. John has spent years researching and developing improved approaches to health. Inve...

Welcome to a special Upgrade Spotlight Edition, where I introduce you to someone who's genuinely changing the game. Our carefully selected guest today is a renowned pharmacist, an author, and a pioneer in biohacking for skin longevity: Dr. Nayan Patel.  Dr. Patel is a trailblazer in the world of antioxidants, specifically glutathione. If you've been following biohacking or are a regular liste...