The Human Upgrade: Biohacking for Longevity & Performance

Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?   Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit...

What are the oral hygiene tips that could save your life?   Dave Asprey sits down with one of the most popular guests on the show, Naveen Jain, founder and CEO of Viome Life Sciences, to explore how your oral microbiome influences not just your dental health but your entire body. Naveen reveals groundbreaking insights into how imbalances in oral bacteria can trigger chronic inflammation, hear...

Is this the missing link in fertility?   The vaginal microbiome could be the most overlooked factor in optimizing women’s health, from fertility and hormonal balance to preventing infections and improving quality of life. In this groundbreaking episode, Dave Asprey talks to Priyanka Jain, co-founder and CEO of Evvy, about how understanding and improving the vaginal microbiome can transform wo...

Is alcohol losing its grip as the go-to social drink?   Enter kava—a centuries-old Polynesian plant that’s gaining global recognition for its ability to relax the mind, elevate mood, and enhance social connection without the toxic effects of alcohol. Kava, particularly in the form of TRU KAVA, is a psychoactive yet non-intoxicating drink that offers the perfect balance of calm focus and menta...

Have we finally discovered the key to youthful energy, longevity, and cellular health?   In this episode, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer at Timeline Nutrition and a leading expert on mitochondrial health, cellular regeneration, and anti-aging science. With over 20 years of research, 50 clinical trials, and 15 patents under his belt, Dr. Singh unpacks the gr...

Are exosomes the planet’s ultimate healing tool?!   In this episode, Dave Asprey sits down with Harvard-trained physician Dr. Edward Park to explore the groundbreaking science of exosomes. Dr. Park, a pioneer in regenerative medicine and author of Exosomes: Songs of Healing , explains how these tiny cellular messengers are revolutionizing health and longevity by bypassing the limitations of s...

Is biohacking your sweat the secret to vitality?   Dave Asprey dives into the transformative world of infrared saunas with Connie Zack, founder of Sunlighten and a 25-year innovator in the space. Together, they uncover how targeted light and heat therapy can unlock unparalleled health benefits, from detoxing heavy metals to energizing your body at the cellular level.  Here’s what you’ll...

What if you could command any room and set boundaries without saying a word?   Dave Asprey sits down with Kasia Urbaniak, founder and CEO of The Academy—a trailblazing school where women learn the true principles of influence and authority. Kasia brings a unique and dynamic perspective, drawing on nearly two decades of experience that includes working as a professional Dominatrix, practicing...

Is unlocking the full potential of your brain even possible, or just a myth from the movie Limitless ?  In this eye-opening episode, neuroscientist and author Dr. Mithu Storoni joins Dave to dive deep into the science of brain optimization for hyper-efficient work performance. Together, they break down the surprising roles of astrocytes in supporting neurons, the influence of the brain’s “blu...

What if the keys to an extraordinary life lie in choices most people wouldn’t dare to make?   In this iconic, unearthed episode, best-selling author and performance pioneer Tim Ferriss joins Dave Asprey to spill the unfiltered truth on smart drugs, insect protein, and the surprising links between sex, creativity, and high performance.  They dig into cutting-edge topics still sparking cur...

What if everything you believe about happiness is wrong?   In this episode, Harvard professor and world-renowned happiness expert Arthur Brooks joins Dave Asprey to unlock the secrets of real happiness, revealing the science behind joy, resilience, and lasting fulfillment. As a bestselling author and co-author with Oprah Winfrey of Build the Life You Want , Arthur has spent decades helping pe...

Explore the science and potential of hypnosis as Dr. David Spiegel, Stanford’s leading expert in mind-body medicine, joins Dave Asprey to reveal how hypnosis can radically enhance cognition, mental clarity, and resilience. In this episode of The Human Upgrade , you’ll learn how hypnosis influences the brain’s most vital networks, including the default mode network and executive control, to break m...

Unlock the mastermind secrets to cognitive enhancement as Dave Asprey shares his ultimate brain-boosting biohacks in this powerful episode of The Human Upgrade . Discover how Dave elevated his IQ, reversed Asperger’s, and overcame brain fog through advanced neurofeedback, BDNF-boosting supplements, mitochondrial enhancers, and the power of the groundbreaking 40 Years of Zen program.  Explore...

Unlock the secret to cellular detox and discover how to cleanse your body from the inside out with Dave Asprey and Jessica Berman in this episode of The Human Upgrade . Explore cutting-edge detox strategies using phosphatidylcholine, Tudca, and butyrate, three powerful molecules designed to remove toxins, microplastics, and endocrine disruptors from your system.  Jessica, co-owner of BodyBio,...

Step into the future of sports performance with The Human Upgrade as Dave Asprey and Aron D’Souza, founder of the Enhanced Games, uncover the controversial world of steroids, gene therapy, peptides, and human enhancement. In this groundbreaking episode, they explore how athletes can push the boundaries of physical and mental performance by embracing cutting-edge science once banned by traditional...

Unlock the power of continuous glucose monitoring (CGM) and transform your health in this eye-opening episode with Dave Asprey. Discover why tracking your blood sugar 24/7 isn’t just for diabetics—it’s the key to unlocking peak health, optimizing your metabolism, and preventing chronic diseases.  Joined by Levels founder and biohacker Josh Clemente, Dave dives into the real science behind CGM...

Get ready to discover the true superfoods that can transform your health—starting with spirulina and chlorella. In this dynamic and thought-provoking episode, Dave Asprey welcomes Catharine Arnston, founder of ENERGYbits, to dive deep into the world of algae and its incredible potential to boost energy, detox the body, and support longevity.  First, we challenge the myths around trendy “super...

Today, we’re diving into the age old question, what is the purpose of your life? We chat about the science behind emotional intelligence with Dr. John Demartini, creator of the groundbreaking Demartini Method.  In this thought-provoking episode, Dr. Demartini reveals how his unique approach to personal development and emotional mastery can help you uncover your highest values and transcend em...

Today, we’re unlocking the full potential of your brain—starting with Bryan Johnson’s Blueprint for longevity and brain optimization.  We’re revisiting our conversation with Bryan, the creator of the Don’t Die movement (among many other things), to explore how his groundbreaking approach to brain health and biohacking is reshaping the future of longevity.  First, we dive into Bryan’s mis...

Today, we’re diving deep into biohacking your body’s performance—starting with your VO2 max and mitochondria.  We’re sitting down with cellular optimization expert, Rowena Gates, to dive into how the NanoVi device is disrupting the world of biohacking, recovery, and training.  First up, we’re breaking down VO2 max—the secret sauce to longevity. Forget endless hours of cardio. Learn how t...

Today, we’re hacking your home—big time. I’m sitting down with three experts who know exactly how your living space might be messing with your health, and more importantly, how to fix it.  First up, we’ve got Michael Rubino, aka the mold medic , who’s here to blow your mind about the invisible toxins lurking in your walls. Mold? It’s everywhere, and it’s doing more damage than you think. Mich...

What if you could control your brain’s performance and stress levels with just a few simple hacks? In this episode callback, Dave Asprey sits down with Dr. Andrew Huberman, a renowned neuroscientist from Stanford University, to unlock the secrets of how your brain really works—and how you can train it for enhanced cognitive power and stress resilience. From rewiring your brain’s fear response to m...

Get ready to upgrade your cardiovascular health in a way you’ve never heard of before. Dave Asprey sits down with Dr. Michael Twyman, a pioneering biohacking cardiologist who blends cutting-edge functional medicine with conventional wisdom to help you avoid heart attacks and strokes. If you think cardiovascular disease is inevitable, think again. Dr. Twyman reveals the hidden mechanisms behind hea...

Are you sleeping enough—or just enough to get by? In this episode of The Human Upgrade , Dave Asprey dives into the global sleep crisis and reveals why mastering your sleep is the most important biohack you can do for your health, performance, and longevity. This episode is your ultimate guide to transforming your rest and, by extension, your life.  First, sleep scientist Matthew Walker break...

Dave Asprey is joined again by glutathione expert Nayan Patel to explore the transformative effects of this “master antioxidant” glutaryl. From skin health and detoxification to energy production and mitochondrial function, glutathione plays a critical role in overall wellness. Nayan shares his cutting-edge research on topical glutathione delivery systems that are more effective than IV treatments...