The Human Upgrade: Biohacking for Longevity & Performance

Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.   In this episode of  The Human Upgrade , Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the la...

Your environment is rewiring your hormones, fertility, and long-term health without your consent.   In this episode of  The Human Upgrade , Dave Asprey sits down with  Dr. Aly Cohen , board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care product...

What if you could reverse the age of your heart...without leaving home?  In this episode of  The Human Upgrade , Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing...

What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition?  In this episode of  The Human Upgrade , Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely pulsed and targeted—can rewire brainwa...

What if mitochondria weren’t just energy engines — but conscious beings guiding your survival and evolution?   In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of cellular intelligence. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively shape consciousness, drive healing, and ac...

You’ve probably heard of HIIT—but have you heard of “REHIT?”  This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time . If you’re still jogging, you’re wasting hours for minimal results.  In this episode of The Human Upgrade , Dave Asprey sits down with Ulrich Dempfle , German-trained engineer and co-founder of CAROL Bik...

Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse.   In this episode, Dave Asprey talks with  Dr. Daniel Pompa , a leading voice in  cellular detox and root-cause healing , to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy.  Dr. Pompa shares his...

Most people run from stress. The world’s highest performers run toward it.   Sébastien Page manages over  $500 billion in global assets . He’s the CIO of one of the world’s largest investment firms, and he wrote  The Psychology of Leadership  while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance, clarity, and control.&n...

Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you.   But what if there was a way to take it back… and hack the system?  In this mind-expanding episode, Dave sits down with two elite hacker-founders— Michael Tiffany , CEO of  Fulcra.ai , and  Vishakh , founder of  Monadic DNA —to explore a radical shift in the way we store...

If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours?  In this mind-altering episode of  The Human Upgrade , Dr. Steven Gundry reveals a startling new theory: your gut microbiome might be controlling your thoughts. F...

If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong?  For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cel...

What if you could rewrite the code of your personality—on command?  Not just  cope  with anxiety, overthinking, or social exhaustion… but  delete  the traits holding you back and install better ones?  This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, an...

Your brain isn’t broken—it’s underpowered.  Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price.  In this episode, Dave sits down with  Dr. Patrick Porter , founder of BrainTap, to reveal how to  reprogram your brain using light, sound, and guided visualization —no substances, no side eff...

You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable.  It feels like love.  But what if it’s making them weak?  In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert  Jennifer Cohen  to reveal how today’s parenting norms are quietly produ...

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?  In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most pro...

For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?  Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery— a newly identified essential fatty acid, C15,  that may hold the key to healthier aging and even longer lifespans. Orig...

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself?  In this episode,  Columbia University psychiatrist and nutritional neuroscience pioneer  Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-i...

You think, you feel, you  are —but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical?  In this episode,  Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey  to challenge everything you think you know about the mind, reality, and human potential. He explores groundbr...

You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize?  In this episode, Scott Barry Kaufman, Ph. D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets . He reveals how toxic altruism, external valid...

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Your Brain is Lying to You—Here’s How to Take Back Control  Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you?  In this episode,  Bizzie Gold , mind architect and creator of  The Break Method , joins Dave Asprey to expose the  self-deception patte...

Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, s...

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story?  Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of  genetic optimization —how understanding your DNA can unlock  longer life, better brain f...

For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is,  habits don’t stick because of repetition—they stick because of emotion!   In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change. BJ, the Stanford researcher behind&...

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective ! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective m...