Talking Rheumatology Research

Dr Polly Livermore (Great Ormond Street Hospital, UK) and Heather Rostron (Leeds Children’s Hospital, UK) join Caroline Groves to discuss their future research plans to improve clinical care and support processes for children, young people, and their families, with rheumatic diseases. Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingRheumResearch, twe...

Dr Ilfita Sahbudin (University of Birmingham, UK) joins Dr Ai Lyn Tan to discuss the relationship between symptom/disease duration and resource utilisation/costs following rheumatoid arthritis diagnosis. Want to read the full paper? Find it here .  Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingRheumResearch, tweet us @RheumJnl , or find us on Insta...

British Society for Rheumatology Young Investigator Award winner Dr Zixing Tian (University of Manchester, UK) joins Dr Steven Zhao to discuss the work behind the winning abstract 'No difference in risk of myocardial infarction among patients receiving either IL6 or TNF inhibitors for rheumatoid arthritis', and the implications for future research.  This abstract was presented at the rhe...

Dr Sean Gill and Dr Chetan Mukhtyar (Norfolk and Norwich University Hospital, UK) discuss the efficacy of tocilizumab for GCA, based on a 12-month extension of Stone et al.’s landmark clinical trial. Dr Mukhtyar provides an overview of the trial, including key findings, limitations, and implications for clinical practice. Read the paper: https://doi.org/10.1093/rheumatology/keab418 Keywords: Giant...

What are the top 10 research priorities in psoriatic arthritis? Louise Hailey and Associate Prof. Laura Coates (both University of Oxford, UK) join Dr Pankti Mehta to discuss. Research priorities were identified by the James Lind Alliance Priority Setting Partnership, comprising people living with PsA, carers and clinicians, and supported by the James Lind Alliance. Read the full paper: The top 10...

Ultrasonography in the prediction of gout flares: a 12-month prospective observational study Dr Edoardo Cipolletta (Polytechnic University of Marche, Italy) joins Marwan Bukhari to discuss the March Editor's choice article on ultrasonography in the prediction of gout flares. Here, Dr Cipolletta discusses whether ultrasonography adds to the value of clinical findings in estimating the risk of...

Effectiveness of the BNT162b2 mRNA COVID-19 vaccine among adolescents with juvenile-onset inflammatory rheumatic diseases (IRDs). Dr Amit Ziv and Prof Yosef Uziel (both Tel Aviv University and Meir Medical Center, Israel) join Dr Herman Tam to discuss the effectiveness of the BNT162b2 mRNA COVID-19 vaccine in preventing infection in adolescents with juvenile-onset IRDs. You can read this article i...

A new autoantibody to valyl transfer RNA synthetase associated with anti-synthetase syndrome  Dr Tsuneo Sasai and Dr Ran Nakashima (both Kyoto University Graduate School of Medicine, Japan) join Dr Latika Gupta to discuss a 43-year-old male patient clinically diagnosed with anti-synthetase syndrome but lacking any known disease-specific autoantibodies. They identify a new autoantibody directed aga...

Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort study   Dr Sara Muller (Keele University, UK) and Prof Samantha Hider (Keele University, UK) join Dr Sheilla Achieng to discuss a follow-up to the PMR cohort study, an inception cohort of 652 patients from English general practices who were diagnosed with PMR between 2012 and 2014. They identify the main findi...

Smartphone images of systemic sclerosis-related digital ulcers provide a clear picture of disease progression for the first rheumatology visit.  Dr Anastasia Madenidou (University of Manchester, UK ) and Dr Graham Dinsdale (Salford Royal Hospital & University of Manchester, UK) join Dr Latika Gupta to discuss their report of a patient with SSc-related digital ulcers who took the initiative to...

In our final episode of 2022, Dr Alla Ishchenko (UZ Leuven, Belgium) joins Dr Latika Gupta to celebrate the achievements of leading women in rheumatology. You can read the full paper here .  Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingRheumResearch, tweet us @RheumJnl , or find us on Instagram and LinkedIn .  Want to read more rheumatology resear...

Dr Sarah Bennett (University of Bristol, UK) joins Prof Diederik de Cock to discuss results from the LIFT study – a randomised trial exploring interventions to support people with fatigue. Here, Dr Bennett talks us through the experiences of both the health professionals delivering these interventions and the patients receiving them.      You can read more about therapist and patient experiences o...

Dr Sarah Khidir and Dr Elise van Mulligen (Leiden UMC, the Netherlands) join Dr Pankti Mehta to discuss the link between educational attainment and clinically suspect arthralgia. Using data from two cohorts, they identified an association between low educational attainment and increased risk of progression from arthralgia to inflammatory arthritis.  Read the paper: https://doi.org/10.1093/rheumato...

Dr Ai Lyn Tan speaks to Dr James Gwinnutt (University of Manchester, UK) about cognitive impairment in people with rheumatoid arthritis. Read the paper here: https://doi.org/10.1093/rap/rkab044 Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingRheumResearch, tweet us @RheumJnl , or find us on Instagram and LinkedIn .  Want to read more rheumatology res...

Dr Chris Wincup and Dr  Marta Alarcón-Riquelme (GENYO, Spain) discuss the use of precision medicine in autoimmune diseases. Find the paper here: https://doi.org/10.1093/rheumatology/keab448 Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingRheumResearch, tweet us @RheumJnl , or find us on Instagram and LinkedIn .  Want to read more rheumatology researc...

On today's episode, Dr Giovanni Adami (Verona, Italy) joins Dr Marwan Bukhari to discuss the association between environmental air pollution and rheumatoid arthritis flares. Read the paper here: https://doi.org/10.1093/rheumatology/keab049 Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingRheumResearch, tweet us @RheumJnl , or find us on Instagram...

Dr Marwan Bukhari (Royal Lancaster Infirmary, UK) and Prof. Maarten Boers (Amsterdam UMC, The Netherlands) join Dr Ai Lyn Tan to discuss the effects of glucocorticoids on bone health. Their observational data suggest that glucocorticoids do not have the detrimental impact on bone health that we have come to expect – a rather controversial finding indeed. Read the paper: https://doi.org/10.1093/rap...

Prof Richard Furie (New York, USA) and Dr Anastasia Madenidou evaluate the Phase 2, randomized, placebo-controlled trial of dapirolizumab pegol in patients with moderate-to-severe active systemic lupus erythematosus. They discuss the unique dose-response relationship endpoint used in this trial and the plans for Phase 3. Read the paper here Thanks for listening to Talking Rheumatology Research! Jo...

Dr Rishi Desai (Boston, USA) and Dr Marwan Bukhari discuss the risk of venous thromboembolism associated with tofacitinib in rheumatoid arthritis. Dr Desai’s recent paper used claims data to compare the risk of VTE with tofacitinib vs. TNFis.  Read the paper here Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingRheumResearch, tweet us @RheumJnl , or f...

Dr Lihi Eder (Toronto, Canada) joins Dr Steven Zhao to discuss ultrasound imaging sub-phenotypes in psoriatic arthritis. They discuss clinical vs. imaging clusters of PsA manifestations, the possibility of coagulation and platelet pathway mediation of imaging phenotypes, and more.  Read the paper here Thanks for listening to Talking Rheumatology Research! Join the conversation on X using #TalkingR...

Prof Christopher Sjöwall (Linköping, Sweden) and Dr Anastastia Madenidou discuss de novo lupus nephritis during treatment with belimumab. They cover the process of collecting observational data, the approval of belimumab for use in lupus nephritis, and implications for clinical practice. Read the paper here: https://doi.org/10.1093/rheumatology/keaa796 Thanks for listening to Talking Rheumatology...

Dr Peter Grayson (NIH, Bethesda, USA) joins Dr Puja Mehta to discuss VEXAS syndrome. They cover the discovery of VEXAS, how to spot the syndrome in patients, the importance of cross-specialty working, and more. Dr Grayson’s NEJM paper can be found here: https://www.nejm.org/doi/10.1056/NEJMoa2026834 This episode was originally published in May 2021.  Thanks for listening to Talking Rheumatology Re...

Today's podcast guest is Dr Lucy Carter (Leeds, UK), who joins Dr Chris Wincup to talk about the Easy-BILAG - a comprehensive but simplified version of the BILAG-2004 index for scoring SLE disease activity. They discuss the user-friendly design, training requirements, use with newly approved drugs, and more. Read the paper here: https://doi.org/10.1093/rheumatology/keab883 Thanks for listenin...

Dr Mark Russell (King's College London, UK) joins Dr Sean Gill to talk about improving outcomes for patients hospitalised with gout. They identify several strategies to improve practice and highlight key gaps in the literature that could be addressed by future research. Read the paper here: https://doi.org/10.1093/rheumatology/keab539 Thanks for listening to Talking Rheumatology Research! Joi...

Dr David Fajgenbaum (University of Pennsylvania, USA) and Dr Puja Mehta discuss cytokine storm syndromes. They consider the definition of cytokine storms and whether COVID-19 meets these criteria, as well as Dr Fajgenbaum’s research journey, as described in his bestselling memoir, 'Chasing my Cure: A Doctor's Race to Turn Hope Into Action'.  Read the paper here: https://www.nejm.org...