Probably Science

Comedian Kirk Smith ( @kirksmithcomedy ) joins Jesse, Andy and Matt to talk about his books Rice Krispies with Ketchup and Movin , pools and jacuzzis, competitive eating champions , the science of fireworks , the lack of rap in the Billboard Hot 100  and Andy's upcoming Oregon tour .

Comedian/author Ryan Conner ( @ryanconnercomedy ) returns to the show to talk with Jesse, Andy and Matt about his new memoir 12 Guys Walk Into a Kitchen , Vietnamese refugees, Tippi Hedren's nail salon legacy , British soccer fans cleaning up in the US, the worst year to be alive , 2020 vs. 1968, hipster nostalgia, stomp clap tall bikes and nuclear (not atomic) clocks .

Zoologist/producer/composer/podcaster Laura Sams ( @lauramsams ) Jordan joins Jesse, Matt and Andy to talk about fliming grizzly bears in Alaska, studying hyenas in Africa, Laura's kid-friendly wildlife podcast The Happiest Animal Show , starting a production company with your sibling , interviewing six-year-olds, Laura's inflatable basking shark , the shocking actual appearance of basking sharks...

Comedian Diana Hong ( @dhongcomedy ) joins Jesse, Andy and Matt to discuss cat ownership, Shadow Force , Sawbones and the McElroy-iverse , Diana's golf career, outsider commemorative art , a new way to get your lithium , battery types, alkali metals reacting with water , Lithium Valley , bottle recycling in the US , Sonny Bono's Palm Springs legacy , awful bronze statues , RIP Primm (maybe) , an o...

Lawyer-turned-comedian and self-professed podcast slut Charles Star ( @ugarles ) returns to the show to talk about his podcast No Homework , celebrity roasts, Wings album covers , bad abbreviations, contact lenses that ease depression in mice , the insect with the biggest nuts , self-recognition in beluga whales  and the link between sleep duration and accelerated aging .

Comedian and former paramedic James Frey ( @jamesfreycomedy ) joins Andy, Jesse and Matt to talk about firefighter dreams and emergency medicine reality, James' Ventura comedy show , giving CPR in civilian life, a woman ( well, women ) who couldn't burp, getting fobbed off, sucker fish hiding in manta rays' butts , a quantum battery breakthrough  and missing scientist conspiracy theories .

Comedian Shane Mauss ( @shane_mauss ) returns to the show to talk about  his upcoming comedy special TRIPS: The First Dose , how LSD affects blind people , misophonia's link to anxiety and depression , the goring of a matador's ass , plants 'hearing' rain coming  and Shane's comedy/science podcast Here We Are .

Comedian Brandie Posey ( @brandazzle ) returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label Burn This Records and her new comedy special Milk Job , Andy's other ska band , why humans can't regenerate limbs , a huge volcano refilling with magma , the dude who got both his arms reattached in 1992 , whether Yellowstone is due for an eruption and Fruit L...

Comedian/speechwriter Chandler Dean ( @chandlerjdean ) joins Jesse, Andy and Matt to talk about his show Abolish Everything! ,  Jesse's over-the-top stuffed animal purchase , poop speed as a health indicator , the Bristol Stool Chart , medical fake poo , Jesse's obsessions with fake foods , giant stuff and really tiny stuff , Artemis II's avatar crewmates , the magic of Tiny Empath Babies , videos...

Comedian Amber Preston ( @prestonparty ) returns to help Andy, Jesse and Matt celebrate the big six-oh-one and talk about Artemis II, frozen urine in space , a microbe that makes you stronger ,  Trump's insane handshakes ,  sharks testing positive for cocaine and  sperm difficulties in zero-g .

Comedian Katie Novotny ( @katienovotnyyyyy ) joins Matt and Andy to discuss her special Son of Your Dreams , whale junk , headbutting whales , the 20-year cycle of fashion , an evolved arsenic tolerance , Thai children who can see underwater  and a Warsaw Poland Bros. song Andy plays on .

Comedian Monica Nevi ( @monicanevi ) joins Andy, Jesse and Matt to talk about her special Big Stepdad Energy , what VO2 max means, esports scholarships, vasectomy rate spikes during March Madness , the effect of carbonated water on gamer performance , a bunch of human brain cells in a petri dish playing Doom , unlocking the antibacterial secrets of frogs  and using frogs to keep milk from spoiling...

Comedian Matthew Coe ( @matthew_coe__ ) joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, the closing of the foramen ovale , a Japanese study of falling cats , a robot handling potato chips , and an averted Moon asteroid close call .

Comedian Jackie Kashian ( @jackiekashian ) returns to the show to talk with Jesse and Matt about her new standup special Alter-Kashian , huge amounts of hydrogen inside the Earth's core , weird things yawning does in your brain  and a possible universal vaccine . See Matt on tour in Seattle and Portland , and Andy on tour in Santa Barbara .

Comedian and former marine biologist Forrest Shaw ( @forrestshaw ) returns to the show to talk with Matt, Andy and Jesse about his new live show The Ocean Hates You , his addiction podcast I've Got A Problem , bonnethead sharks , the rise of online sports gambling , a Kalshi market about aliens , and the myth of alpha wolves .

Comedian Aisha Alfa ( @aishaalfa ) joins Jesse, Andy and Matt to talk about comedy in Winnipeg,  Jesse's Megyn Kelly-loved Olympics tweet , the cult movie Phantom of the Paradise , Andy's family friend Olympic ice dancer , the German word for a living stork with an arrow in it , the penis injection Olympic ski jumping controversy , an amazing artificial lung feat , Jesse's artificial lung cat bed,...

Comedian David Huntsberger returns to the show to talk with Matt, Jesse and Andy about his podcast Intercepts , his new platform The Endless Abyss ,  the lost art of sketch comedy albums , the world's worst redaction , Redactle , how dogs build their vocabularies like toddlers , Stella the talking dog , dumb dogs , breed stereotypes , Bad Will Hunting , the worst logo and name in education , longe...

Comedian/neuroscientist Diya Basrai ( @diyabasrai ) joins Jesse, Andy and Matt to talk about Moravec's Paradox , whether there's something meat-specific about intelligence, a less-pessimistic AI take , a tool-using cow , Diya's comedy special  and his comedy/science live show Uncontrolled Variables .

Comedian Jon Stringer ( @jonjstringer ) joins Andy, Jesse and Matt to talk about living in a converted rural Kansas church, the intricacies of comedy competitions and cruise ship comedy, dry ice PVC soupcan launchers,  the oldest known use of poison arrows , retail blowguns and their misuse , vibe-coding a band manager, why you should stop using hydrogen peroxide on cuts , sword canes and pendulou...

Comedian Imaan Hadchiti ( @imaanfrankhadchiti ) joins Jesse, Andy and Matt to talk about Rima syndrome, the movie Tiptoes , the passing of an art legend , sniffing farts to prevent Alzheimer's , what actually causes ice to be slippery , when physical aging really kicks in  and making paralyzed rats walk again in a really creepy way .

Comedian/actor/writer/composer Waen Shepherd ( @waenshep ) joins Andy, Jesse and Matt to talk about the new album from his alter ego Gary Le Strange , the biology of elves , the best chocolate chip cookie recipe , a runaway supermassive black hole , a lemon-shaped exoplanet  and the music of Gary Wilson .

Comedian/host/author Chris Duffy ( @chrisiduffy ) returns to the show to talk with Jesse, Andy and Matt about his new book Humor Me: How Laughing More Can Make You Present, Creative, Connected, and Happy , his radio show/podcast You're The Expert , his TED podcast How To Be a Better Human , the unintentionally phallic Covid-era Terry Crews video Chris worked on with Matt and Andy , prescribing sta...

Comedian Buddy Fitzpatrick ( @buddycomic ) joins Andy, Matt and Jesse to talk about  Batman's effect on subway chivalry ,  the rooms of Madonna Inn , ladyfingers , manmade fire from 350,000 years earlier than previously thought , monogamy across the animal kingdom and  an insane chain of rabies transmission via organ transplantation .

Comedian Adam Burke ( @atpburke ) joins Andy, Jesse and Matt to talk about Adam's new comedy special Unamerican , debunking the Stanford Prison Experiment , classic '80s Arnold movies, Matt and Jesse performing together in Nashville, the preacher who shot an escaped lab monkey , AIs that believe themselves to be more rational than humans , 3D printing with a mosquito proboscis , Andy's upcoming or...

Comedian/writer/ NPR host Ophira Eisenberg ( @ophirae ) joins Andy, Jesse and Matt to talk about her podcast Parenting Is a Joke , her upcoming special produced by Lewis Black, the effect of venting on anger , a rage room show Andy worked on , why you should leave uncontacted tribes alone , the wombat-thief influencer  and why you should speak up to seagulls .