Physiological Reviews Podcast

In this episode Associate Editor Dr. Hilary Critchley (University of Edinburgh) and Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interview author Dr. Serdar Bulun (Northwestern University) about the recently published Review article by Bulun et al. on the critically important topic of uterine fibroids. Listen as we shed light on this underrecognized and under researched top...

In this episode Editor-in-Chief Dr. Sadis Matalon (University of Alabama Birmingham) interviews author Dr. Laura Crotty Alexander (University of California, San Diego) about the recently published Review article by Masso-Silva et al. on the impact of e-cigarette vaping on the immune system across the body. We discuss in depth how vaping limits the ability of alveolar macrophages to protect the bod...

In this episode Associate Editor Dr. George Cotsarelis (University of Pennsylvania) and author Dr. Ralf Paus (University of Manchester) discuss the Review article by Altendorf on male pattern androgenetic alopecia. We uncover the physiology and function of hair in a wide-ranging and engaging conversation. In addition to producing pigmented protein fibers, the “mini organ” that makes our hair shaft...

In our latest episode, Associate Editor Dr. John Orlowski (McGill University) interviews Dr. Matthias A Hediger (University of Bern) about the new Review article by Gyimesi et al. published in Physiological Reviews on the intracies of a superfamily of membrane solute carriers that is critically important to our understanding of human health and disease. This extensive Review contains over 3500 cit...

What is the difference between forward and reverse cardio-oncology? In our latest episode, Deputy Editor Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Rudolf de Boer (Erasmus Medical Center) about the new Review article by Meijers et al. Forward cardio-oncology focuses on cardiotoxicity and cardiac damage due to anti-cancer therapies in patients with prevalent cancer. In contrast, r...

What role does inflammation play in atherosclerosis? In our latest episode of The Physiological Reviews Podcast, Dr. Carol Ann Remme talks with authors Dr. Esther Lutgens (Mayo Clinic) and Dr. Claudia Monaco (University of Oxford) about their recent Review on immunotherapy for atherosclerosis. The authors discuss the network of multiple immune cell types and subsets of the innate and adaptive immu...

What is cerebral small vessel disease and why is it such a critical area of research? In this episode, Associate Editor Dr. Scott Earley (University of Rochester) interviews author Dr. Anne Joutel (Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM) about the pathogenic diagnosis and molecular basis of cerebral small vessel disease (cSVD). Classified into two categori...

In this episode, Dr. Jan Born (University of Tübingen) interviews his colleague and author Dr. Andreas Nieder (University of Tübingen) about his recent Review in Physiological Reviews on mathematical reasoning that incorporates neurobiology, comparative physiology, and neurophysiology. Mathematical skills can be described as falling into symbolic (arithmetic, number theory) and non-symbolic (set s...

In the episode, Dr. Willis K. “Rick” Samson (Saint Louis University School of Medicine) interviews lead author Dr. Eric Lazartigues (Louisiana State University Health Sciences Center) about the recent Review by Chhabra et al. on the latest discoveries related to the role of ACE2 in glucose homeostasis and regulation of metabolism. What are the consequences, in terms of pancreatic function and gluc...

In the episode, Dr. Mark Donowitz (Johns Hopkins School of Medicine) interviews Dr. Pietro Invernizzi (IRCCS Fondazione San Gerardo dei Tintori; University of Milano-Bicocca) and Dr. Vincenzo Ronca (University of Birmingham; Humanitas University) about their recent Review article that describes the immune function of the liver. Listen as these experts discuss immune tolerance in the liver, sex dif...

In the episode, Dr. Sadis Matalon (University of Alabama Birmingham) interviews Dr. Catherine Dulac (Howard Hughes Medical Institute, Center for Brain Science, Harvard University) about the new Review in Physiological Reviews by Kaplan et al., which explores the neural basis of the complex social behavior of parenting. Parenting behavior is absolutely essential for the development of human beings...

In the episode, Dr. Carol Ann Remme (University of Amsterdam) and Dr. Sadis Matalon (University of Alabama Birmingham) interview Dr. Jenny Van Eyk (Cedars-Sinai) about the Review in Physiological Reviews by Karpov et al. that dives into proteomics of the heart. Given that proteins are the building blocks of life, studying only genetic data or RNAseq data may offer researchers a somewhat narrow vie...

What are the biological, neural, and psychological mechanisms of resilience to trauma, stress, and adversity? In this episode, Dr. Jan Born (University of Tübingen) interviews Dr. Raffael Kalisch (Leibniz Institute for Resilience Research) about the open access Review in Physiological Reviews by Kalisch et al. By unraveling the protective mechanisms of stress resilience, the authors hope to find n...

In our latest episode, Physiological Reviews Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews authors Dr. Leigh Peterson (Executive Vice President for Product Development and Xenotransplantation at United Therapeutics Corporation) and Professor Sir Magdi Yacoub (Professor of Cardiothoracic Surgery at the National Heart and Lung Institute at Imperial College London...

In our latest episode, Dr. Farrah Kheradmand (Baylor College of Medicine) interviews Dr. Kevin Harrod (University of Alabama at Birmingham) about his article by Patton et al. on community-acquired bacterial coinfections and COVID-19. In the early days of the pandemic when physicians were treating critically ill COVID patients, there was no standard definition for bacterial coinfections in this coh...

The topic of hypertension is of paramount clinical importance as a significant risk factor for cardiovascular disease, myocardial infarction, stroke, and kidney disease. Sex differences in blood pressure regulation play a major role in the pathophysiology of hypertension. In the episode, Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Thu Le (University of Rochester) about her new Rev...

In this episode of The Physiological Reviews Podcast, Professor Giovanni Mann (King’s College London) interviews authors Prof. Marzia Perluigi (Sapienza University of Rome) and Prof. D. Allan Butterfield (University of Kentucky) about their recently published Review on the oxidative stress hypothesis of Alzheimer Disease. The authors provide a comprehensive overview of amyloid beta-peptide associa...

As Sir Winston Churchill once said, “Where there is great power, there is great responsibility.” This is the overarching context of our latest episode about the future of artificial intelligence (AI) in physiology and healthcare. Listen as host Dr. Ryan Melvin (University of Alabama at Birmingham) interviews author Dr. James Zou (Stanford University) about the Review by Zhang et al. on “Leveraging...

What are the key physiological adaptations attained in exercise regimens used by elite athletes to achieve peak performance? In our latest episode of The Physiological Reviews Podcast, Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews author and Physiological Reviews Associate Editor Dr. Christoph Handschin (University of Basel, Switzerland) about the new Review by...

Genetics studies, including genome-wide association studies (GWAS), play an increasingly important role in physiology and pathophysiology studies of cardiovascular disease. Listen as Deputy Editor Dr. Carol Ann Remme interviews authors Prof. Jeanette Erdmann (University of Lübeck, Germany) and Prof. Connie Bezzina (Amsterdam University Medical Center, Netherlands) about their latest Review in Phys...

How do changes in concentration of stratospheric ozone impact human health and the global ecosystem? In our latest episode Editor-in-Chief Dr. Sadis Matalon interviews lead author Professor Christos Zerefos about the recent Review titled, “The long-term variability of human health related solar ultraviolet-B radiation doses from the 1980s to the end of 21st century.” Because stratospheric ozone is...

Physiological Reviews Associate Editor Prof. Christoph Handschin speaks with Prof. Paul L. Greenhaff and Prof. Janet M. Lord about their article “ Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity ,” published in the April 2023 issue of Physiological Reviews. Prof. Greenhaff is Professor at the School of Life Sciences at the University of Nottingham and...

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Dr. Paule V. Joseph about her article “ A Systematic Review of the Biological Mediators of Fat Taste and Smell ,” the first systematic review to be published in Physiological Reviews. Dr. Joseph is Lasker Clinical Research Scholar, Tenure Track Clinical Investigator, and Chief of the Section of Sensory Science and Metabolism in th...

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with    Prof. John P.A. Ioannidis about his editorial “ Systematic Reviews for Basic Scientists: A Different Beast ,” which focuses on the importance of systematic reviews in scientific research. Prof. Ioannidis is Professor of Medicine, of Epidemiology and Population Health, and, by courtesy, of Statistics and Biomedical Data Science...

Physiological Reviews Associate Editor Prof. Giovanni Mann speaks with Prof. Rafael Radi about his review article “ The superoxide radical switch in the biology of nitric oxide and peroxynitrite ,” about the life of a scientist, and about advice for early-career researchers. Prof. Radi is Professor, Chair, and Director of the Centro de Investigaciones Biomédicas (CEINBIO) at the Universidad de la...