Forecast 2050

Enveda Founder and CEO Viswa Colluru believes we have been looking for new medicines in the wrong places for decades. In the Season 1 finale of Forecast 2050, I sat down with Viswa and Pablo Lubroth, VP of Special Projects at Enveda, to discuss why 9 in 10 drugs fail in clinical trials despite Big Pharma spending $276 billion in annual R&D, how AI is finally unlocking 99% of nature's chemi...

Devon Zuegel believes America has been building cities wrong for decades. She grew up spending summers in Chautauqua, an intellectual community in western New York where four generations of her family shared a household and she knew her neighbors better than the ones at home in California. Now she's building a village called Esmeralda 90 minutes north of San Francisco to prove that formula can...

Matt Clifford and Ian Hogarth believe Europe is roughly a decade behind the United States in building the technology companies that will define the next era. But they also believe that the gap can be closed, and that the UK and Europe could even leapfrog America, if political leaders and the public make fundamentally different choices. I sat down with Matt, co-founder of Entrepreneurs First and ar...

Yanai Yedvab thinks we need to completely overhaul the infrastructure of humanity to avoid a climate disaster, and we can't afford to wait the 70 years it’ll take to wean off fossil fuels. Before founding Stardust, Yanai spent nearly three decades in Israeli nuclear research, ending up as deputy chief scientist at the Israel Atomic Energy Commission. Stardust is developing reflective particles...

Casey Handmer thinks we're living through the most consequential 25 years in human history, and that human civilization is just getting started. I sat down with Casey in Los Angeles to discuss how China's dominance in solar energy deployment should be a wake-up call for the West, why antimatter is the only rocket fuel that makes interstellar travel possible, and how slowing down aging may...

Starcloud Founder and CEO Philip Johnston believes data centers in space are the first step to becoming a Kardashev level civilization. I caught up with Philip at Starcloud’s HQ to talk about his vision for the next 25 years. The conversation covers everything from luxury space tourism, whether Tesla’s Optimus robot will become a self-replicating galactic probe, the hard problem of consciousness,...

Sir Malcolm Rifkind served as Foreign Secretary of the United Kingdom from 1995 to 1997 and as Defence Secretary before that. He has sat across from Soviet ministers while a KGB double agent secretly briefed both sides, watched the Berlin Wall fall when nobody saw it coming, and has been banished from Russia by Putin personally for his criticism of the invasion of Crimea. I sat down with Sir Malco...

Noor Siddiqui is building a future free of inherited disease. As Founder & CEO of Orchid, she has developed embryo screening technology that reads 99% of an embryo's DNA - 100 times more information than legacy tools. In this episode of Forecast 2050, Nebular General Partner Finn Murphy sits down with Noor in San Francisco to discuss why embryo screening and artificial wombs may become the def...

Scott Aaronson thinks that the time to prepare for a post-quantum world isn’t years away - it was yesterday. In the second episode of Forecast 2050 with Nebular General Partner Finn Murphy and Entrepreneur in Residence Tom McCarthy, we explore whether classical AI might eclipse quantum computing, how post-quantum cryptography will upend global security, and why the rise of superintelligence both e...

Tyler Cowen believes we are woefully unprepared for the next 25 years. In the first episode of Forecast 2050 with Nebular General Partner, Finn Murphy, we discuss the real reason behind falling birthrates, what the last human job might be in an AI-dominated economy, how conflict and war could evolve in the next 25 years, whether we will have a "viagra for the mind," why we are experienci...

Forecast 2050 is a series about the next 25 years, and the builders, thinkers, and leaders shaping what lies ahead. Hosted by Nebular General Partner Finn Murphy.