Endocrine Feedback Loop

For our 74th episode, recorded live at ENDO 2026 in Chicago, we review a recent JCEM study that addresses a common clinical question: does levothyroxine need to be taken on an empty stomach? This randomized clinical trial evaluates a dose-adjusted, non-fasting regimen and finds that a 15% increase with breakfast ingestion achieves TSH stability similar to that with standard fasting dosing. The res...

For our 73rd episode and the start of the seventh season, we review a recent study examining the long-term anti-fracture efficacy of infrequent zoledronate dosing in women with osteopenia. While current clinical approaches typically focus on treating individuals at higher fracture risk, this study explores whether earlier intervention in lower-risk populations may help reduce fracture risk over ti...

For our 72nd episode and the final episode of the sixth season, we review a recent study examining the perioperative medical management of primary aldosteronism, with a focus on the use of mineralocorticoid receptor antagonists before adrenalectomy. Primary aldosteronism is increasingly recognized as a common and clinically important cause of secondary hypertension, yet questions remain about opti...

For our 71st episode, we review a randomized, placebo-controlled clinical trial that explores how semaglutide may influence taste perception in women with obesity and polycystic ovary syndrome. While GLP‑1 receptor agonists are widely used for weight loss, the mechanisms underlying changes in food preference remain less well understood. This study takes a multimodal approach to examine whether sem...

For our 70th episode, we review a paper that tries to improve our understanding of remission in Graves’ disease. Long-term thionamide treatment has long been the preferred approach internationally in Graves’ disease, and only more recently here in the U.S. So, the more we know about dosing and how that might encourage or predict remission, the better. This report is an observational study, as is o...

For our 69th episode, we review a paper in The Journal of Clinical Endocrinology & Metabolism on the gut microbiome of adolescents with type 1 diabetes, which hopes to understand differences between those with a normal body mass index compared to obesity. Studying gut microbiomes has been a “hot topic” for several years now, and we are excited to take the opportunity to unpack this work and se...

For our 68th episode, we look at a paper in The Journal of Clinical Endocrinology & Metabolism that compares the effect on calcium of initial and subsequent doses of denosumab in people with chronic kidney disease (CKD). Though concerns have arisen over the years about the problems with stopping denosumab therapy, it remains an appealing medication for some of our patients with CKD. So we thou...

For our 67th episode, we look at a study in The Journal of Clinical Endocrinology & Metabolism that reports the impact of different types of weight-loss surgery on body composition, muscle strength, and bone density. Our patients frequently ask questions about these changes with surgical and medical weight loss, so we thought it highly worthwhile to review these findings with you all. Host Cha...

For our 66th episode, we review a recent Journal of the Endocrine Society (JES) article that looks at the frequency of positive islet antibodies in a population of adults without diabetes. While that may initially seem like an unusual article choice, we found it to be quite helpful in an era where we now have a therapeutic option to delay the onset of clinical type 1 diabetes when we can identify...

For our 65th episode, we return to The Journal of Clinical Endocrinology & Metabolism to look at a report of two different studies that investigate the relationship between MACS (mild autonomous cortisol secretion) and vertebral fractures. MACS has been of increasing interest to endocrinologists over the past few years, with a greater recognition of its health impact and new guidelines on its...

For our 64th episode, we return to The Journal of Clinical Endocrinology & Metabolism to review a recent paper that attempts to elucidate the connection between subclinical thyroid disease and cardiovascular disease. Any of you listeners who see patients with thyroid conditions likely frequently encounter people with mild thyroid abnormalities and need to figure out if those abnormalities may...

For our 63rd episode, we returned to the Endocrine Society’s annual meeting and recorded before a live audience at ENDO 2025 in San Francisco. We look at a study from The Journal of Clinical Endocrinology & Metabolism that suggests that we can substantially alter our diagnostic approach to adrenal insufficiency. This study and others have already led to a shift in recommendations from some exp...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recently published article in The Journal of Clinical Endocrinology & Metabolism that investigates the impact of primary hyperparathyroidism on fertility and pregnancy outcomes. Those who take care of primary hyperparathyroidism will have encountered the challenge of managing it around pregnancy and...

Welcome to our 61st episode and the beginning of our sixth season! Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recently published clinical trial in The Journal of Clinical Endocrinology & Metabolism that tries to understand the impact of genetics on the benefits of a lifestyle program in reducing the risk of developing type 2 diabetes. Person...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent study in The Journal of Clinical Endocrinology & Metabolism that reports on the benefits of older weight-loss medications in a population of women with polycystic ovary syndrome (PCOS). Much of the attention today in obesity medicine focuses on GLP-1 receptor agonists. However, these medicati...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent investigation in The Journal of Clinical Endocrinology & Metabolism that tries to illuminate the relationship between serum testosterone and fractures in men. Ever since the release of the TRAVERSE fracture findings last year, we as endocrinologists have been uncertain in how to think about t...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a study in The Journal of Clinical Endocrinology & Metabolism that reports the relationship between body mass index and percent body fat in terms of defining overweight and obesity. He talks with Andrew Kraftson, MD, from the University of Michigan and guest expert Beverly Tchang, MD, from Weill Corne...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a study in The Journal of Clinical Endocrinology & Metabolism that gives insight into how we should wean patients off long-term glucocorticoid use and how successful that typically is. He talks with Salila Kurra, MD, from Columbia University and guest expert Felix Beuschlein, MD, from University Clini...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in Journal of the Endocrine Society assessing plasma renin in the management of individuals with primary adrenal insufficiency. He talks with Jill Wagoner, MD, from the University of Nebraska and guest expert Irina Bancos, MD, from Mayo Clinic. The article featured this month, by Piaz...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent systematic review and meta-analysis in The Journal of Clinical Endocrinology & Metabolism about the role for T3 replacement in the treatment of people with hypothyroidism. He talks with Andrew Crawford, MD, from Dartmouth-Hitchcock Medical Center and guest expert James Hennessey, MD, from Bet...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism providing data in support of metformin being renal protective. He talks with Steven D. Wittlin, MD, from the University of Rochester Medical Center and guest expert Silvio Inzucchi, MD, medical director of the Yale Medicine Diabete...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism about the impact of molecular testing for indeterminate thyroid nodules. He talks with Anupam Kotwal, MD, from the University of Nebraska Medical Center, and guest expert Sarah Mayson, MD, from the University of Colorado School of...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism about the benefits of surgical cure of primary hyperparathyroidism in women with osteopenia. He talks with Alyson Myers, MD, from Albert Einsten College of Medicine, and guest expert Natalie Cusano, MD, from the Zucker School of Me...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism about polycystic ovarian syndrome. He talks with Anna Goldman, MD, from Harvard Medical School, and guest expert David Ehrmann, MD, from the University of Chicago. The article featured this month, by van der Ham et al, was first pu...

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion recorded in front of an audience at ENDO 2024 in Boston. He talks about a recent article in The Journal of Clinical Endocrinology & Metabolism with Amal Shibli-Rahhal, MD, from University of Iowa Carver College of Medicine, and guest expert Ghada El-Hajj Fuleihan, MD, from the American University of Beirut,...