Depresh Mode with John Moe

Microdosing involves taking very small amounts of psychedelic substances such as LSD or psilocybin, maybe seven to twelve percent of a regular dose. It’s not enough to “trip out” but enough, proponents say, to yield very positive results, especially in terms of treating depression that hasn’t responded well to other methods. The catalog of extensive clinical, scientific trials about the practice o...

Ophira Eisenberg once believed that everyone had a trauma quota, a maximum amount of hardship that a person would face in life and once that mark was hit, nothing bad would ever happen again. It was a way of comforting herself after a car accident at age eight that seriously injured Ophira and killed her friend. Turns out that’s not how life works and Ophira still had cancer and a miscarriage to d...

Would you get a device the size of a Nilla wafer implanted in your body if it meant relief from treatment-resistant depression? There are big advances being made in vagal nerve stimulation therapy, a process by which electrical impulses are fed into a patient’s vagus nerve to alleviate depression that hasn’t responded to more common treatments. We take a look at the science, the breakthroughs, and...

The cover of Neko Case’s memoir features a young Neko in a swimsuit she says she wore for six months straight and she’s accompanied by a drawing of a big spiky-toothed monster who she says is there to protect her. The invention of such monsters can feel necessary when one’s parents are unavailable, simply not physically present, or, in the case of her mother, faking their own death only to reappea...

Sex is not always an easy topic to discuss. Issues like how to get what you want, how to make sure your partner is getting what they want, these are delicate conversations and often intimidating ones as well. Add in issues like depression and anxiety for one or more of the people involved and it becomes more complex still. Fortunately, we have Dr. Emily Nagoski with us who is an expert on sex and...

Hari Kondabolu has never been afraid to talk about sensitive topics on stage. The veteran comedian, who has appeared on Conan, Kimmel, Letterman, and NPR’s Wait Wait... Don’t Tell Me mined material about race, immigration, and other societal hot button issues. But unlike some comedians, he was hesitant to discuss himself and in particular the depression that has followed him for years. He goes the...

On the podcast Hyperfixed , host Alex Goldman sets out to solve mysteries and conundrums that listeners submit. But he’s found himself having to do some figuring out for himself. Alex finally got diagnosed with ADHD just a few years ago, when he was around 42 years old. Which was a big relief after years of struggling with things like attention and task completion. The problem was that the meds th...

There are sad movies that nonetheless offer some sort of hope and optimism. And then there are the ones that offer no hope at all, just bleakness and despair and the cinematic versions of major depressive disorder. Those are our focus on this episode as a trio of film critics and pundits offer their picks for the most depressing films and offer analysis on whether there is value in watching works...

Trauma and comedy wouldn’t seem to have a lot in common but they do have one thing: Paul Scheer. You may know Paul from TV shows like the comedy The League or from his podcasts like How Did This Get Made . In this deeply personal, vulnerable, and – yes – funny interview and in his new memoir, Joyful Recollections of Trauma , Paul Scheer recounts tales of the repeated physical and mental abuse he a...

Writing is not what Cory Richards is best known for. No, that would be feats like being the first American to climb one of the 14 peaks in the world measuring over 8000 meters. He’s also known for his photography, which includes National Geographic covers. But Cory’s new book, The Color of Everything: A Journey to Quiet the Chaos Within, isn’t just about his accomplishments, it’s about his struggl...

Lead was added to car fuel back in the twenties and wasn’t phased out in America until 1996. By then, according to neuropsychologist and researcher Dr Aaron Reuben, the damage had very much been done. He’s one of the authors of a new study pointing to 151 million cases of mental illness that correlate with the presence of lead in gas tanks. The people damaged the most were those born during the hi...

Home for Richard Sarvate wasn’t anything like the home lives of his friends. Unlike his friends, his mom was convinced Richard was trying to kill her and that Bill Clinton was sending her secret messages because they had the same birthday. Richard shares stories of growing up with an abusive mom who had schizophrenia, what that meant for the development of his social skills and sense of self, and...

Twin Cities comic Ellie Hino was wondering if her young son might have attention deficit hyperactivity disorder or ADHD, so she looked into the symptoms. What she found was a pretty good rundown on problems that she had been wrestling with for many years, especially since becoming a mom. After extensive testing, her diagnosis was confirmed, which opened up the possibilities of treatment and led to...

David Shaw’s anxiety was more than just a feeling in his mind, it was in his ears as well. The frontman of the popular rock band The Revivalists found himself dealing with hyperacusis, a condition of extreme hypersensitivity to sounds that would ordinarily be considered tolerable, which was a hindrance in his job as lead singer of a rock band. David talks about managing his anxiety through a varie...

During a decades long career in the United States Army, Gregg Martin just kept on succeeding. Star cadet at West Point, getting promoted up to two-start General, earning PhD degrees along the way, and receiving glowing evaluations all the while for his boundless energy and enthusiasm. He now knows that he was operating under a condition called hyperthymia, being in a constant state of near mania....

Youngmi Mayer says she hates doing research but, in our conversation and in her new memoir I’m Laughing Because I’m Crying , she does a lot of digging into the events of her life and what they all meant. Youngmi grew up in Saipan and Korea, the daughter of a Korean mother and a White American father, and had to deal with discrimination, harassment, and abuse. Later on, she moved to America with $7...

This episode of our show is premiering the day before Election Day in the U.S. and loads of people are just a mess with worry and anxiety. We don’t know the future and we’re not a politics show but we can provide you with a list of 13 stories that might make you feel that we’re getting somewhere as a society with mental health. Learn about the improving mental state of young people, advancements i...

Imagine serving your country in the military, incurring some trauma and some mental health difficulties, and then finding that your appointments to get mental health treatment keep getting canceled without explanation. And in many cases, it’s you, the patient, being unfairly blamed for canceling or not showing up to the appointments. That’s happening now in America’s veteran healthcare system, acc...

If you’ve ever tried to treat major depressive disorder, you know that it can be absolutely exhausting. That’s because for a long time the approach has been one of trial and error, taking a certain med, it doesn’t work, try a different one, try therapy, try something else, try, try, try. Stanford University researcher Dr. Leanne Williams is attempting a methodology with a better batting average: t...

Singer/songwriter Bishop Briggs lost her sister, her best friend, her roommate, and her manager all on one day in January 2021. They were all the same person. After Kate’s death, swiftly following her diagnosis of ovarian cancer, Bishop plunged into a dark place, not eating, not really engaging with the world, and being increasingly haunted by thoughts of suicide. Ultimately, she found a path towa...

How Do You Feel? is the title of Dr. Jessi Gold’s new memoir about her life as a psychiatrist dealing with her own mental health and the health of other medical providers during the first wave of the covid pandemic. The answer to the question the title poses would be, “Not very good at all.” Dr. Gold profiles composites of several patients in the medical profession who felt the need to be perfect,...

Xiu Xiu, the highly experimental avant-garde rock band from California has just released their 14th album, 13" Frank Beltrame Italian Stiletto with Bison Horn Grips . It refers to a type of switchblade, which Jamie Stewart from the band collects. In this interview, Jamie tells us of the multi-generational cycle of abuse within their family and of the suicide of their father. Jamie also discusses t...

Zac Carper, lead singer and guitarist for the garage punk bad FIDLAR, is very familiar with one kind of drugs: the street substances of meth, heroin, and crack that he engaged in heavily when he was younger. Now, at 37, he’s grappling with a different sort: medications prescribed for his newly diagnosed bipolar disorder. Zac has found that, while he needs some help managing the intense hypomanic e...

Yes, we don’t have to wear masks in the grocery store and yes, vaccines have been very effective in reducing the spread and severity of covid-19. But the mental health ramifications of the whole pandemic experience are only now beginning to be understood. Dr. Royce Lee from the University of Chicago joins us to talk about how it made serious mental illnesses much worse due to the virus and the str...

The U.S. election is weeks away and a lot of people are kind of a mess right now. It can feel like the whole world is on the line and you have no real power over what happens. This can result in election stress disorder, the overwhelm of panic and anxiety that can interfere with your life functions and peace of mind. We’re joined by Theresa Nguyen, Chief Research Officer for Mental Health America...