CogNation

For the third time, Joe and Rolf talk to Dr. Balazs Szigeti about psychedelics for the treatment of depression. This time, Balazs discusses his recent paper that shows an equivalence between psychedelics and traditional medications in effectiveness for treating depression. This is surprising, given the size of effects that have been demonstrated in some early psychedelic trials, and can be account...

On this episode, Rolf and Joe talk to Dr. Valerie Bonnelle, a cognitive neuroscientist interested in the relation of processes in the body to peak experiences. We discuss her paper showing how heart rate variability and the interplay between the sympathetic and parasympathetic nervous systems closely tracks phenomenological experience during the use of the psychedelic DMT. Bonnelle, V., Feilding,...

What do the National Institutes of Health (NIH) do, and who works there? Rolf and Joe talk to Dr. Bradley Cooke , who works at the NIH as a Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases (located within the National Institute of Diabetes and Digestive and Kidney Diseases). Dr. Cooke talks about the research he conducted when he was in the academic world, includ...

Fresh from Psychedelic Science 2025, Dr. Steve Levine, the chief patient officer at Compass Pathways, talks to us about new Phase 3 results for psilocybin in treating depression.

Joe reports back from the Psychedelic Science conference held recently again in Denver, Colorado. After some discussion about the conference, Joe speaks with Balasz Szigeti (who was on the podcast in 2023) about his recent work on the "Placebo Suppression Effect" in psychedelic research.

Joe and Rolf talk to blind activist and friend of the show Josh Miele.  Josh, a MacArthur Genuis Award winner and prodigious sushi eater, has just come out with a new autobiographical book called "Connecting Dots: A Blind Life".   We talk about his life growing up  in Park Slope, his freewheeling youth, the dog vs. cane debate, and his career as a blind accessibility scientist...

Rolf and Joe talk to NYU philosopher Jeff Sebo about his new book "The Moral Circle", which makes the case for expanding our circle of who is deserving of ethical consideration to nonhuman animals, insects, plants, and AI systems.

Rolf and Joe wrap up their 3-part series on dreaming with Finnish neuroscientist and philosopher Antti Revonsuo. Dr. Revonsuo is the originator of the Threat Simulation theory of dreams, which suggests that dreams are simulated worlds in which we may practice threatening situations. Topics include the history and methodology in dream research, how our brains create simulated worlds, the particular...

In their second episode in a series on dreaming, Joe and Rolf are joined by Dr. Pilleriin Sikka, a Stanford neuroscientist who is currently studying the therapeutic value of dreams under anesthesia.  Hack, L. M., Sikka, P., Zhou, K., Kawai, M., Chow, H. S., & Heifets, B. (2024). Reduction in Trauma-Related Symptoms After Anesthetic-Induced Intra-Operative Dreaming. American Journal of Psy...

Why do we dream, and what is the meaning of our dreams? Rolf and Joe talk about several ideas about dreaming, including a new theory by David Eagleman called the "defensive activation theory", which proposes that dreams are like a screen saver to keep the visual parts of the brain from being overtaken by other senses. Eagleman, D. M., & Vaughn, D. A. (2020). The Defensive Activation theory: dr...

Daniel Dennett, who passed away on April 19th at the age of 82, was one of the great philosophers of our time. Rolf and Joe discuss his ideas and his influence on the field of philosophy, including (especially) bringing consciousness back as a topic of serious study with his book "Consciousness Explained", as well as his work on free will, evolution, religion, and constructing a convincing argumen...

What can neuroscience teach us about AI, and vice versa, what can AI teach us about our own intelligence? Joe and Rolf talk to returning guest Daniel Sternberg about advances in AI over the past year. Topics include using the methods of cognitive psychology to understand AI; representation in artificial intelligence; what current large language models  (LLMs) are good at and not good at; sent...

This episode is dedicated to the memory of colleague and friend Grace Baron . Joe and Rolf talk to Dr. Matthew Goodwin, a professor at Northeastern University whose research focus is on autism. His most recent paper used biosensing (heart rate, skin conductance, etc.) to predict aggressive behavior in profound autistic individuals up to three minutes before the event. 

Joe and Rolf discuss the ideas of perceptual psychologist Donald Hoffman, who has argued that our perceptual systems have no access to reality, since evolution is driven by fitness functions, not objective truth. He has also argued that our perception is a user interface (like a desktop on a computer, or a VR headset), and that objects such as the moon don't exist when we are not apprehending them...

Neil Markey, a veteran of Iraq and Afghanistan, used meditation for years to deal with depression and PTSD. He is currently CEO of Beckley Retreats, a group that runs retreats to Jamaica and the Netherlands for guided psychedelic experiences. He talks about his path from the military to consulting to his work with Beckley, how guided psychedelic retreats are run (including work to prepare in advan...

We discuss the recent controversy about Integrated Information Theory (IIT), a theory about the neural correlates of consciousness, with Felipe De Brigard, a philosophy and psychology professor at Duke University who signed a letter describing the theory as pseudoscience. The letter: https://osf.io/preprints/psyarxiv/zsr78/ The adversarial collaboration: https://journals.plos.org/plosone/article?i...

Joe and Rolf talk to psychedelic researcher Robin Carhart-Harris. Robin is at the cutting edge of research on the therapeutic benefits of psychedelics such as psilocybin (magic mushrooms), LSD, and DMT. He discusses psychotherapy and the unconscious mind, models of what psychedelics are doing in the brain, and many other topics. A really fascinating and in-depth conversation. You can find links to...

Joe and Rolf discuss new work in neural interfaces that is helping paralyzed individuals communicate. Based on the recent Nature article: Metzger, S. L., Littlejohn, K. T., Silva, A. B., Moses, D. A., Seaton, M. P., Wang, R., ... & Chang, E. F. (2023). A high-performance neuroprosthesis for speech decoding and avatar control. Nature, 1-10.

Rolf and Joe discuss two philosophical theories of the self, Bundle Theory and Ego Theory, based on a paper by Derek Parfit. They return to the topic of the teletransporter, and although Joe is happy to go through the teletransporter, Rolf is convinced it means certain death. Parfit, D. (2016). Divided minds and the nature of persons. Science Fiction and Philosophy: From Time Travel to Superintell...

In this episode, CogNation goes to the Psychedelic Science conference in Denver to get in on all the excitement. We present four interviews from the conference that represent a range of ideas about the resurgent interest in psychedelics as therapeutics. Bekely Waves The East Institute Balasz Szigeti Manoj Doss

Everyone has a set of beliefs. Increasingly, it seems like we wonder how so many people can hold opposite or contradictory beliefs -- puzzling if we think there's an objective reality. We have a great conversation with Mark Solomon, a clinical psychologist and the host of the Being Reasonable podcast, about Street Epistemology, a conversational method of probing why we believe what we believe. htt...

Manesh Girn talks to us about the effects of psychedelics on the brain, based on his recent paper, " A complex systems perspective on psychedelic brain action ". We discuss the current state of psychedelics as therapeutics, and how information theory can model changes in brain states that result from taking psychedelics. Special Guest: Manesh Girn.

We talk with Professor Gail Sahar about her new book, entitled "Blame and Political Attitudes: The Psychology of America's Culture War", where she applies social psychology to understand where and why we assign blame in the political sphere. https://www.amazon.com/Blame-Political-Attitudes-Psychology-Americas/dp/303120235X

We talk to Dr. Daniel Sternberg, head of data at Notion Labs, about how to understand new developments in AI (artificial intelligence) like DALL-E-2 and chatgpt. Topics include the possibility for general intelligence in AI, similarities between human cognition and generative AI models, and the potential for sentient AI.

Stephanie Preston (University of Michigan) returns to the show to talk about her latest research. Why do we hoard stuff? And how can we get people to care about the consequences of all that stuff on the environment? Her research has taken her from the strategies that some rats use to hide seeds (some hide in lots of small caches, while others hoard in a single location), to the cognitive/neural/em...