The Journal Club

Gopaulchan, D., Moore, C., Ali, N.  et al.  A defined microbial community reproduces attributes of fine flavour chocolate fermentation.  Nat Microbiol  (2025). https://doi-org.ccmain.ohionet.org/10.1038/s41564-025-02077-6

mWAKE in the Central Amygdala Regulates Fear Learning and MemoryJiali Xiong, Anuradha Mehta, Qiang Liu, Anna X. Luo, Pan P. Li, Patricia H. Janak, Mark N. WuJournal of Neuroscience 20 August 2025, e0225252025;  DOI:  10.1523/JNEUROSCI.0225-25.2025

Trabanelli, S., Akselrod, M., Fellrath, J.  et al.  Neural anticipation of virtual infection triggers an immune response.  Nat Neurosci  (2025). https://doi.org/10.1038/s41593-025-02008-y

Liu, YN., Wang, QW., She, XY.  et al.  A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors.  Nat Neurosci  (2025). https://doi.org/10.1038/s41593-025-02040-y

Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation

Mey GM, Evonuk KS, Shelestak J, Irfan M, Wolfe LM, Laye SE, Schafer DP, DeSilva TM. Inhibiting AMPA receptor signaling in oligodendrocytes rescues synapse loss in a model of autoimmune demyelination. iScience. 2024 Oct 22;27(11):111226

McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R. The use of behavioral test batteries: effects of training history. Physiol Behav. 2001 Aug;73(5):705-17.

Liu, Y., Fontenot, M.R., Kulkarni, A.  et al.  Human CLOCK enhances neocortical function.  Nat Neurosci  (2025)

Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction

Lee SS, Liu Q, Cheng AHR, Kim DW, Boudreau DM, Mehta A, Keles MF, Fejfer R, Palmer I, Park KH, Münzberg H, Harris TD, Graves AR, Blackshaw S, Wu MN. Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep. Science. 2025 Jun 19

Parbst F, Kostka JK, Günther A, Chen YN, Hanganu-Opatz IL, Bitzenhofer SH. Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-Challenged  Disc1+/-  Mice. J Neurosci. 2025 Jun 18

Li R, Inoue R, Mori H, Hirano A, Sakurai T. Functional Roles of Gastrin-Releasing Peptide-Producing Neurons in the Suprachiasmatic Nucleus: Insights into Photic Entrainment and Circadian Regulation. J Neurosci. 2025 Jun 18

Sakairi T, Kawabata M, Rios A, Sakai Y, Isomura Y. Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents. J Neurosci. 2025 Jun 18

Mossa, A., Dierdorff, L., Lukin, J.  et al.  Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene  DDX3X .  Nat Commun   16 , 4512 (2025)

Chari, T., Hernandez, A., Couto, J.  et al.  A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism.  Nat Commun   16 , 4600 (2025). https://doi.org/10.1038/s41467-025-59852-6

Kawamura, A., Fujii, K., Tamada, K.  et al.  Duplication of the autism-related gene  Chd8  leads to behavioral hyperactivity and neurodevelopmental defects in mice.  Nat Commun   16 , 4641 (2025). https://doi.org/10.1038/s41467-025-59853-5

Guasch-Ferré, M., Wittenbecher, C., Palmnäs, M.  et al.  Precision nutrition for cardiometabolic diseases.  Nat Med   31 , 1444–1453 (2025)

Muncke, J., Touvier, M., Trasande, L.  et al.  Health impacts of exposure to synthetic chemicals in food.  Nat Med   31 , 1431–1443 (2025)

Soroka T, Ravia A, Snitz K, Honigstein D, Weissbrod A, Gorodisky L, Weiss T, Perl O, Sobel N. Humans have nasal respiratory fingerprints. Curr Biol. 2025 May 30

Romano, S., Wirbel, J., Ansorge, R.  et al.  Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease.  Nat Commun   16 , 4227 (2025)

Lechat, B., Manners, J., Pinilla, L.  et al.  Global warming may increase the burden of obstructive sleep apnea.  Nat Commun   16 , 5100 (2025)

Watanabe, T., Yamasue, H. Noninvasive reduction of neural rigidity alters autistic behaviors in humans.  Nat Neurosci   28 , 1348–1360 (2025)

da Rocha, J.F., Lance, M.L., Luo, R.  et al.  Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing.  Nat Neurosci  (2025).

Athar, F., Zheng, Z., Riquier, S.  et al.  Limited cell-autonomous anticancer mechanisms in long-lived bats.  Nat Commun   16 , 4125 (2025)

Shao, LX., Liao, C., Davoudian, P.A.  et al.  Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors.  Nature   642 , 411–420 (2025)