Manifold

Peter Byrne is an investigative reporter and science writer based in Northern California. His popular biography, The Many Worlds of Hugh Everett III - Multiple Universes, Mutual Assured Destruction, and the Meltdown of a Nuclear Family (Oxford University Press, 2010) was followed by publication of The Everett Interpretation of Quantum Mechanics, Collected Works 1957-1980 , (Princeton University Pr...

Jeffrey D. Sachs is a world-renowned economics professor, bestselling author, innovative educator, and global leader in sustainable development. Professor Sachs serves as the Director of the Center for Sustainable Development at Columbia University and is a University Professor, Columbia's highest academic rank. Steve and Jeffrey discuss: 0:00 Jeffrey Sachs’ experience on the Lancet Commission for...

Rob Henderson grew up in foster homes in California, joined the Air Force at 17, attended Yale on the G.I. Bill, and is currently a Gates Fellow at Cambridge University (UK). He is an acute observer of American society and has coined the term Luxury Beliefs to describe ideas and opinions that confer status on the rich at very little cost, while taking a toll on the lower class. Steve and Rob discu...

Professor Lyle Goldstein recently retired after 20 years of service on the faculty of the U.S. Naval War College (NWC). During his career at NWC, he founded the China Maritime Studies Institute (CMSI) and has been awarded the Superior Civilian Service Medal for this achievement. He has written or edited seven books on Chinese strategy and is at work on a book-length project that examines the natur...

The guest for this episode is a recent graduate of Harvard College, now pursuing a STEM PhD at another elite university. We have withheld his identity so that he can speak candidly. Steve and his guest discuss: 0:00 Anonymous student’s academic background and admission to Harvard 21:37 Intellectual curiosity at Harvard 29:36 Academic rigor at Harvard and the difference between classes in STEM and...

Richard Lowery is a professor of finance at the McCombs School of Business at the University of Texas, Austin. In this conversation, he describes the ideological climate of his university and the consequent negative effects on undergraduate education and freedom of expression on campus. Links: Richard Lowery at UT Austin: https://www.mccombs.utexas.edu/faculty-and-research/faculty-directory/james-...

Tim Palmer is Royal Society Research Professor in Climate Physics, and a Senior Fellow at the Oxford Martin Institute. He is interested in the predictability and dynamics of weather and climate, including extreme events. He was involved in the first five IPCC assessment reports and was co-chair of the international scientific steering group of the World Climate Research Programme project (CLIVAR)...

Kishore Mahbubani is Distinguished Fellow at the Asia Research Institute, National University of Singapore.    Kishore enjoyed two distinct careers: in diplomacy (1971 to 2004) and in academia (2004 to 2019). He is a prolific writer and speaker on geopolitics and East-West relations.   He was twice Singapore’s Ambassador to the UN and served as President of the UN Security Council in January 2001...

Gregory Clark is Distinguished Professor of Economics at UC-Davis. He is an editor of the European Review of Economic History, chair of the steering committee of the All-UC Group in Economic History, and a Research Associate of the Center for Poverty Research at Davis. He was educated at Cambridge University and received a PhD from Harvard University. His areas of research are long-term economic g...

This interview with John Mearsheimer was conducted in 2020 on the original Manifold podcast with Corey Washington and Steve Hsu. Parts of the conversation are prescient with respect to US-China relations and the situation in Ukraine. John Joseph Mearsheimer is an American political scientist and international relations scholar, who belongs to the realist school of thought. He is the R. Wendell Har...

Theodore A. Postol is professor emeritus of Science, Technology, and International Security at the Massachusetts Institute of Technology . He is widely known as an expert on nuclear weapons and missile technology. Educated in physics and nuclear engineering at MIT, he was a researcher at Argonne National Lab, worked at the Congressional Office of Technology Assessment, and was scientific advisor t...

Raghu Parthasarathy is the Alec and Kay Keith Professor of Physics at the University of Oregon. His research focuses on biophysics, exploring systems in which the complex interactions between individual components, such as biomolecules or cells, can give rise to simple and robust physical patterns. Raghu is the author of a recent popular science book: So Simple a Beginning: How Four Physical Princ...

Carl Zha is the host of the Silk and Steel podcast , which focuses on China, history, culture, and politics. He is a former engineer now based in Bali, Indonesia. Find Carl on Twitter @CarlZha . Steve and Carl discuss: 1. Carl’s background: Chongqing to Chicago, Caltech to Bali, Life as a digital nomad 2. Xinjiang (35:20) 3. Ukraine (1:03:51) 4. China-Russia relationship (1:16:01) 5. U.S.-China co...

Scott Aaronson is the David J. Bruton Centennial Professor of Computer Science at The University of Texas at Austin , and director of its Quantum Information Center . Previously, he taught for nine years in Electrical Engineering and Computer Science at MIT. His research interests center around the capabilities and limits of quantum computers, and computational complexity theory more generally.  ...

Sebastian Mallaby is a writer and journalist whose work covers financial markets, international relations, innovation, and technology. He is the author of "The Power Law: Venture Capital and the Making of the New Future." Steve and Sebastian discuss venture capital, tech startups, business model and technology innovation, global adoption of the Silicon Valley model, and the future of innovation. B...

Vlatko Vedral is Professor in the Department of Physics at the University of Oxford and Centre for Quantum Technologies (CQT) at the National University of Singapore . He is known for his research on the theory of Entanglement and Quantum Information Theory . Steve and Vlatko discuss:  History of quantum information theory, entanglement, and quantum computing Recent lab experiments that create sup...

Richard Sander is Jesse Dukeminier Professor at UCLA Law School. AB Harvard, JD, PhD (Economics) Northwestern. Sander has studied the structure and effects of law school admissions policies. He coined the term "Mismatch" to describe negative consequences resulting from large admissions preferences. Topics discussed:   1. Early life: educational background and experience with race and politics in A...

Shai Carmi is Professor of Statistical and Medical Genetics at Hebrew University (Jerusalem). Carmi Lab: https://scarmilab.org/ Twitter: https://twitter.com/ShaiCarmi   Topics and links: Shai's educational background. From statistical physics and network theory to genomics. Shai's paper on embryo selection: Schizophrenia risk. Modeling synthetic sibling genomes. Variance among sibs vs general popu...

Jon Y produces Asianometry, which focuses on Asia technology, finance, and history: Podcast , YouTube channel , and Substack . Steve and Jon discuss the global semiconductor industry with an emphasis on U.S.-China technology competition.   Topics discussed: Jon's background and his move to Taipei. Key components of the semiconductor ecosystem: fabs, lithography, chip design. US-China tech war TSMC...

Richard Hanania is President of the Center for the Study of Partisanship and Ideology (CSPI). He is a former Research Fellow at the Saltzman Institute of War and Peace Studies at Columbia University. His interests include personality differences between conservatives and liberals, morality in international politics, machine learning algorithms for text analysis, and American foreign policy. In add...

Steve answers questions about recent progress in AI/ML prediction of complex traits from DNA and applications in embryo selection. Highlights: Overview of recent advances in trait prediction Would cost savings from breast cancer early detection pay for genotyping of all women? How does IVF work? Economics of embryo selection Whole embryo genotyping increases IVF success rates (pregnancy per transf...

James Lee is a professor of psychology at the University of Minnesota. He is a leading researcher working in behavior genetics and statistical genetics. In this episode, he discusses recent progress in the genomic prediction of complex traits such as cognitive ability and educational attainment. Lee also discusses his recent Wall Street Journal editorial on embryo selection, Imagine a Future Witho...

Steve and Corey talk to Warren Hatch, President and CEO of Good Judgment Inc. Warren explains what makes someone a good forecaster and how the ability to integrate and assess information allows cognitively diverse teams to outperform prediction markets. The hosts express skepticism about whether the incentives at work in large organizations would encourage the adoption of approaches that might lea...

Corey and Steve interview Leif Wenar, Professor of Philosophy at Stanford University and author of Blood Oil. They begin with memories of Leif and Corey’s mutual friend David Foster Wallace and end with a discussion of John Rawls and Robert Nozick (Wenar’s thesis advisor at Harvard, and a friend of Steve’s). Corey asks whether Leif shares his view that analytic philosophy had become too divorced f...

Steve and Corey speak with Dr. Michael Kauffman, co-founder and CEO of Karyopharm Therapeutics, about cancer and biotech innovation. Michael explains how he and Dr. Sharon Schacham tested her idea regarding nuclear-transport using simulation software on a home laptop, and went on to beat 1000:1 odds to create a billion dollar company. They discuss the relationship between high proprietary drug cos...