Immune

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis , exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts:  Cynthia Leifer ,  Stephanie Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Helminth pro...

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Mast cells  and immune avoidance behavior (Nature...

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts:  Vincent Racaniello , Cynthia Leifer , and Steph Langel Download  Immune 66  (45 MB .mp3, 76 min) Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Immun...

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts:  Vincent Racaniello ,  Cynthia Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for...

Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server COVID-1...

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts:  Vincent Racaniello ,  Cynthia Leifer ,  Steph Langel , and  Brianne Barker Guest:  Jonathan C. Kagan Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a ...

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of...

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CAR T for SLE (Nat MEd) Maternal gut microbiome induced IgG (Sci Immunol) Long-primed germinal centers (Nat...

De'Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guests D'Broski Herbert Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Immunology of...

From SLB22 on the Island of Hawai'i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guests: Julia Bohannon and Musa Mhlanga Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this e...

Somali and Phil join Immune to discuss their approaches to immunology education. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Sumali Pandey and Phil Mixter Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode ImmunoReach ASMCUE: ASM Conference for Undergraduate Educators (ASMCUE) Upcoming...

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be 'good' or 'bad' in their function. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Mandy McGeachy Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links...

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Lin...

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Bacteria induce skin regeneration via IL-1beta (Cell Host Mic...

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Al Singer Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode T cell FlipFl...

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode KIR+CD8+ regulatory T cells...

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Age-dependen...

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts:  Vincent Racaniello , Cynthia Leifer, and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Trogocytosis in Immune 18 B cells steal from dendritic cells (Science) Tim...

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Gabriel Victora Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Concerto in B ( TWiV 161 ) Visualizi...

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Nikhil Joshi Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this...

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode DNA binding to TLR9 on red blood cells (Sci T...

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Keke Fairfax Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Beco...

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Timothy Ha...

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Antiviral IgA potentiates NETosis (PNAS) Lett...

Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Dampened STING in bats (Cell...