Immune

Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Basophils  promote asth...

Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron...

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with  Plasmodium parasites leads to development of B cell cancers. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode...

Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men). Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Guest:  Petter Brodin Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Serve...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Mark Shlomchik to talk about his career and the research of his laboratory on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis. Hosts:  Cindy Leifer  and  Steph Langel Guest:  Mark Shlomchik Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Imm...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Heather Caslin Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune!...

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness. Hosts:  Vincent Racaniello ,  Cindy Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode Mic...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey. Hosts:  Cindy Leifer  and  Steph Langel Guest:  David Martinez Subscribe (free): Apple Podcasts ,  RSS ,  email Become a ...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Robert Binder to talk about his career, the research of his laboratory on the role of heat shock proteins in cancer immunosurveillance, and the importance of inspiring students as early as possible to think about science. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Robert Binder Subscrib...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections. Hosts:  Cindy Leifer  and  Steph Langel Guest:  Rafael Polidoro Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patro...

Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Stephanie Langel  and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Hosts: Cindy Leifer  and  Steph Langel Guest:  Jane Buckner Subscribe (free): Apple Podcasts ,  R...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Tonya Webb Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Music by  Tat...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Michal Tal to talk about her career, sex differences in immune responses, and how one giant mouse uterus changed the trajectory of her research career. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Michal Tal Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Mus...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne where meet up with Luis Montaner to talk about his career and his research on boosting the immune system to combat viral diseases or cancer progression. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Luis Montaner Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for th...

Immune travels to Chicago for the American Association of Immunologists conference where they meet up with Joseph Larkin III to talk about his career and his research on the contribution of T lymphocyte subsets and functions in maintaining tolerance. Hosts:  Stephanie Langel  and  Brianne Barker Guest:  Joseph Larkin III Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune!...

Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health. Hosts:  Stephanie Langel ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Intr...

Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,...

Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,  gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts:  Vincent Racaniello ,  Steph Langel ,  Cynthia Lei...

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello ,  Steph Langel ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Trans endothelial migration  ...

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts:  Vincent Racaniello ,  Steph Langel ,  Cynthia Leifer , and  Brianne Barker Guest:  Juliet Morrison Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free):  Apple Podcasts...

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Guest:  Ang Cui Subscribe (free): Apple Podca...

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts:  Stephanie Langel ,  Cynthia Leifer , and  Brianne Barker Guest:  Carla R. Nowosad Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become...

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Immun...

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hosts:  Vincent Racaniello  and  Cynthia Leifer Guest:  Ellen Rothenberg Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free):  Apple P...