Double-stranded

In this deep dive, we break down the journey of the PIM Kinase target. We explore the complex PIM1 molecular mechanism, examine why first-generation pan-PIM inhibitors like AZD-1208 faced safety issues and a lack of monotherapy efficacy, and reveal the final clinical verdict of the Terminated and Completed Phase 1 studies. 📖 Video Chapters: 0:00 - Intro 1:05 - Biobanks Associations for PIM1 22:18...

Disclaimer: This video is for educational purposes only and should not be used for medical diagnosis or treatment decisions. Always consult with healthcare professionals for medical advice. In this episode, we explore the association between the PEAR1 gene and various platelet disorders. Using data and research, we aim to explain the significance of platelet count and the effects of thrombocytopen...

KGWAS is a novel geometric deep learning method that leverages a massive functional knowledge graph across variants and genes to significantly improve detection power in small-cohort GWASs. Thank you, Kexin Huang and Martin Jinye Zhang, for joining me on this one. Preprint: https://www.medrxiv.org/content/10.11... GitHub Page: https://github.com/snap-stanford/KGWAS Official Website: https://kgwas....

This podcast was made possible by CIUT-FM 89.5, University of Toronto Community Radio. For more content visit https://ciut.fm/ Link to the paper: https://www.nature.com/articles/s41586-025-08916-0 Join me in a conversation with two of the authors, Lakshmi Mahendrawada and Steven Hahn.

This podcast was made possible by CIUT-FM 89.5, University of Toronto Community Radio. For more content, visit https://ciut.fm/ Join us for this comprehensive masterclass episode as we explore the fascinating world of K562 cells with Dr. Tom Karagiannis, who has worked with these remarkable cells for almost three decades. From his first encounter with them as a young researcher in 1996 during the...

Dr. Andrew Paterson is a Senior Scientist in Genetics & Genome Biology at SickKids and a Professor at the Dalla Lana School of Public Health, University of Toronto. His work focuses on uncovering the genetic basis of diabetes and its complications. In this episode, we discuss the real promise—and current limits—of GWAS in diabetes research, why the X chromosome is still often ignored, how data...

If you’ve ever analyzed sequencing data, chances are you’ve used tools developed by Phil Ewels —whether you knew it or not. He’s the creator of MultiQC , a key developer behind Nextflow and nf-core , and a major advocate for making bioinformatics workflows scalable, reproducible, and user-friendly . In this episode, we dive into: 🔬 How MultiQC became the standard for bioinformatics quality contro...

Welcome to today's episode. I'm excited to introduce our guest, Dr. Senjuti Saha , the Deputy Executive Director of the Child Health Research Foundation in Bangladesh. Dr. Saha is a trailblazer in genomic research and a passionate advocate for equitable science education. From her discovery of the chikungunya virus as a cause of pediatric meningitis to her leadership roles with the WHO and her pro...

Professor Joly is an internationally acclaimed figure in health law, intellectual property, and bioethics, leaving an enduring impact on the ethical landscape of modern medicine. With pivotal roles in the International Cancer Genome Consortium (ICGC) and the International Human Epigenome Consortium (IHEC), he has spearheaded the development and implementation of controlled access mechanisms in gen...

In this episode, we delve into the intricate world of the human pangenome with Cristian Groza, a Ph. D. student specializing in bioinformatics from Bourque lab at McGill University. A Draft Human Pangenome Reference paper Connect with Cristian here Connect with me here This podcast is powered by Pinecast .

Episode Notes Dr. Sarah Gagliano Taliun is a researcher affiliated with the Montréal Heart Institute and the Université de Montréal. She specializes in neurogenetics, complex traits, and genomics. Her research focuses on understanding genetic factors and tackling questions surrounding human health from a mechanistic and biological perspective. She employs state-of-the-art computational and bioinfo...

Episode Notes Dr. John A. Morris is a Postdoctoral Scientist at the New York Genome Center, supported by a NHGRI K99 Fellowship. His work aims to understand common human genetic variation through genome editing. connect with him on Twitter or LinkedIn . See STING-seq preprint here Check out these great Twitter threads on STING-seq here and here connect with me on Twitter https://linktr.ee/double_s...

Episode Notes Dr. Daniel Taliun is a Human Genetics Assistant Professor at McGill University. His research interests are in developing computational algorithms and software tools for analyzing genetic data combined with molecular, behavioural, imaging and environmental data. His scope of research includes genomic and clinical data integration, web-based analytical tools and interactive visualizati...

Dr. Raquel Cuella Martin joined the Department of Human Genetics and the Canada Excellence Research Chair in Genomic Medicine as an assistant professor in August 2022. Dr. Martin's current research employs large-scale precision genome editing to investigate the DNA damage response and its connection to human disorders. Her lab aims to integrate DNA repair and checkpoint control activities to preve...