Decoding Longevity

What if the greatest breakthrough in longevity isn't slowing aging—but preventing disease before it begins? In this episode of Decoding Longevity , we speak with Professor Linda-Gail Bekker , one of the world's leading experts in HIV prevention, tuberculosis research, and global public health. Together, we explore how HIV research has transformed our understanding of longevity, from restor...

What can hibernating squirrels teach us about aging, disease, and human health? In Episode 28 of Decoding Longevity, we sit down with Dr. Ashley Zehnder, Co-Founder and CEO of Fauna Bio, to explore how evolution-driven drug discovery is uncovering new therapeutic opportunities for some of humanity’s most challenging diseases. Ashley explains how animals that naturally withstand oxygen deprivation,...

What if aging is not just damage — but a biologically regulated process shaped by metabolism, inflammation, and gene expression? In this episode of Decoding Longevity, Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging, joins us for a wide-ranging conversation on the molecular biology of aging. We explore how metabolism influences epigenetics, why immune aging may be ce...

Can aging cells be reset — without turning them into stem cells? In Episode 26 of Decoding Longevity , Dr. Janine Sengstack explains how Genevity is using AI, human data, and RNA therapeutics to identify the master regulators of aging and restore cells to healthier states. This episode explores the intersection of aging biology, transcription factors, siRNA therapeutics, and precision longevity me...

What if the biggest barrier to healthy longevity isn’t scientific—but philosophical, economic, and ethical? In this episode of Decoding Longevity , Raghav Sehgal and Macsue Jacques are joined by Dr. Raiany Romanni-Klein to explore how our beliefs about aging, death, and human value shape the future of longevity science. From the idea that “natural is good” to the economic incentives holding the fi...

Aging might not be inevitable. In this episode of Decoding Longevity , Dr. Michael Ringel (COO, Life Biosciences) explains how scientists are learning to “reset” the biological age of cells—without changing what they are. From reversing vision loss in preclinical models to launching one of the first human trials, this conversation explores a future where we don’t just treat diseases of aging—we ta...

What if aging isn’t defined by disease — but by how much function we preserve over time? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques sit down with Stephen Kritchevsky to explore how mobility, metabolism, and physiological resilience shape the aging process. From walking speed as a powerful integrative biomarker… to why muscle quality may matter more than muscle mass… to...

What if the biggest barrier to extending healthy human lifespan isn’t the science — but policy? In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques speak with Dylan Livingston, founder of the Alliance for Longevity Initiatives. Together, they explore why public policy may be one of the most important — and overlooked — drivers of progress in longevity science. From buildi...

What if the future of medicine is preventing aging-related disease before it begins? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques speak with James Peyer, CEO of Cambrian Biopharma, about turning aging biology into real therapeutics. We explore exercise-mimetic drugs, metabolism reset therapies, mTOR inhibition, and the path to the first approved gerotherapeutics.

In this episode of Decoding Longevity, host Raghav Sehgal and co-host Macsue Jacques explore one of the most powerful — and often overlooked — drivers of aging: the immune system. Joined by immunologist Alan Landay, the conversation uncovers how chronic inflammation — often described as inflammaging — shapes biological aging at the cellular level. Drawing on decades of HIV research, Dr. Landay exp...

In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques are joined by Dr. Karl Pfleger — angel investor, longevity industry analyst, and creator of AgingBiotech.info. We explore the rapidly growing aging biotech ecosystem, including: Repairing aging vs. slowing aging Rejuvenation biotech and combination therapies Longevity investing, biomarkers, and regulation Why ecosystems...

What if healthy longevity depends not only on your DNA, but on the city you live in, the air you breathe, and the communities you’re part of? In this episode, Raghav Sehgal and Macsue Jacques talk with Tina Woods — CEO of Collider Health and leading voice of the Human Exposome Project — about how environmental, social and lifestyle exposures shape aging. You’ll learn: What the human exposome is an...

What if we could produce safe, ethical, and infinitely renewable stem cells — without relying on embryos or complex reprogramming? In this episode, Raghav Sehgal and Macsue Jacques sit down with Yuta Lee , Founder and CEO of Accelerated Biosciences , to explore how his team is pioneering a new source of true pluripotent stem cells that could transform regenerative medicine and longevity research....

What if cardiovascular disease wasn’t just about high cholesterol — but about a toxic, oxidized form that drives plaque buildup and cellular dysfunction? In this episode, hosts Raghav Sehgal and Macsue Jacques talk with Matthew “Oki” O’Connor , a leading researcher exploring how 7-ketocholesterol fuels atherosclerosis — and how a new therapeutic candidate could reverse aspects of this age-related...

What if aging research didn’t just happen in labs but through a global community of people contributing their data and testing interventions in real time? In this episode, hosts Raghav Sehgal and Macsue Jacques talk with Jasmine Smith, CEO of Rejuve. AI, about how Decentralized Science (DeSci), AI, and n-of-1 trials are transforming personalized longevity research. 👉 Learn more about Rejuve. AI:...

What if we could measure and manage aging as precisely as we treat disease? In this episode of Decoding Longevity , host Macsue Jacques talks with Prof. Brian Kennedy from the National University of Singapore’s Healthy Longevity Translation Research Program about the future of precision medicine in aging . They explore: The LeanAge 2 Clock : a biomarker-based tool predicting biological age , morta...

What if healthcare could not just extend life, but extend healthy life? In Episode 13 of Decoding Longevity , hosts Raghav Sehgal and Macsue Jacques welcome Prof. Andrea B. Maier , a leading voice in geriatric medicine and longevity research , to explore the future of precision geromedicine . This episode uncovers how data-driven, personalized approaches are transforming the way we think about agi...

What if we could predict aging more accurately than ever before? In this episode of Decoding Longevity , we sit down with Dr. Amin Haghani (Altos Lab) to explore EnsembleAge , a powerful new epigenetic clock designed to integrate multiple biomarkers into a single measure of biological age. We discuss: Why EnsembleAge could represent the “next generation” of aging clocks 🧬 The challenges of combin...

What if aging in brain cells could be switched on—or reversed? In this episode of Decoding Longevity , hosts Raghav Sehgal and Macsue Jacques speak with Dr. Nathalie Saurat about her groundbreaking CRISPR screen revealing neddylation as a critical regulator of neuronal aging , Alzheimer’s disease progression , and protein turnover . You’ll learn how Nathalie: Generated 2.8 billion human stem-cell-...

What if aging wasn’t a steady decline—but a mosaic of cellular behaviors? In this episode, we explore the complex biology of senescent cells with Dr. Iman Azimi, whose recent study using image-based single-cell profiling reveals an unprecedented diversity within these “zombie” cells. Together with hosts Dr. Raghav Sehgal and Dr. Macsue Jacques , we dive into: 🧬 The hidden heterogeneity of senesce...

We can now estimate your biological age from just a few drops of blood—but how close are we to using these tests in your doctor’s office? In this episode of Decoding Longevity , hosts Dr. Macsue Jaques and Dr. Raghav Sehgal sit down with Dr. Chiara Herzog , a molecular biologist and aging researcher at King’s College London, to unpack the translational bottlenecks holding back biomarkers of aging...

Can one gene reverse aging without the cancer risk? In this episode, we sit down with Dr. Lucas Paulo de Lima Camillo to discuss SB000—a single factor that could make cellular rejuvenation safer and more effective. Lucas walks us through the science behind this new preprint, how SB000 compares to the well-known OSKM cocktail, and what this could mean for the future of aging therapies. 🧬 Topics Co...

What if a single drop of blood could do more than tell your biological age? In this episode, we explore how cutting-edge epigenetic biomarker proxies and OMICmAge clocks can predict disease risk, personalize health interventions, and reshape how we approach aging itself. Our special guest, Dr. Varun Dwaraka , computational biologist and lead author of two groundbreaking papers, joins hosts Dr. Rag...

In this second part of our mind-expanding conversation with Peter Fedichev, co-founder of Gero, we explore what it will take to move longevity science forward. Peter argues that aging is a thermodynamic process — and that the loss of resilience begins before disease. So how can we detect that tipping point? And are mice really a dead end in anti-aging research? We also talk about: Why animal model...

Is aging just the sum of diseases, or is it something deeper? In this episode, we’re joined by physicist and Gero founder Peter Fedichev , who introduces a groundbreaking new framework: aging as a loss of thermodynamic stability . We explore: Why aging is a systemic phenomenon beyond individual pathologies How concepts from physics and complex systems can redefine longevity science The limits of c...