Authentic Biochemistry

ImmunoepigeneticsXV. In utero fetal exposure to high concentration of maternal cortisol can induce histone code hypomethylation proximal to the TGF B-1 receptor resulting in adult OA.DJGPhD.12Jan23 13.01.2023 29:51 ↓

References Stem Cell Res Ther. 2021; 12: 163 Biomedicines. 2021 Nov; 9(11): 1666

ImmunoepigeneticsXIV. Epithelial cell metabolism and the potential transition to mesenchyma is regulated by TGF-Beta and linked to ALK-1 receptor associated OA. DJGPhD.11Jan23.Authentic Biochemistry. 11.01.2023 30:00 ↓

References Clin Podiatr Med Surg . 2001 Jan;18(1):35-53 Biomedicines. 2021 Nov; 9(11): 1666

Biochemical Consequences of Sensorial Phenomenology V. The possibility of Necessary biological modality . DJGPhD. 09Jan23. Authentic Biochemistry. 10.01.2023 29:57 ↓

References A plenum of  time.

ImmunoepigeneticsXIII. The interplay of NFKappB and articular cartilage glycosaminoglycan metabolism in regulating pro-inflammatory cytokine expression in OA. DJGPhD.Authentic Biochemistry. 08Jan2023 08.01.2023 29:17 ↓

references J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161 Connect Tissue Res. 2017 Jan; 58(1): 49–63.

ImmunoepigeneticsXII. Osteo-Arthritis 1. Clinical manifestation and the role of TGF-Beta. DR. Daniel J. Guerra. 06Jan2023. Authentic Biochemistry Podcast Productions 07.01.2023 29:45 ↓

References Connect Tissue Res. 2017 Jan; 58(1): 49–63 J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161

Cytoepigenetics XI. The Treg essential linneage specific transcription factor FOXp3 promoter is regionally variably demethylated and acetylated to control Th immunosuppression.DJGPhD.04.Jan.23. 04.01.2023 30:00 ↓

References Front. Immunol. 2015. 6: 493. Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55

Epistemological integration into realized metaphysics III. Mensam de phaenomenus and the concept of evidentiary existentialism in research science. DJGPhD.01Jan23.Authentic Biochemistry. 02.01.2023 29:40 ↓

References Anaximander 6th century B.C. Plato-Timaeous 4th century B.C. Kant 1781 Critique of Pure Reason Basic quantum physics notes Dr Guerra Neuroscience lectures  

ImmunoEpigenetics X(A). Inhibtion of histone trimethyl-Lys demethylases as arbiter of controlling human Acute Myeloid Leukaemia (AML). Dr Daniel J. Guerra. 30.12.22. Authentic Biochemistry 31.12.2022 30:00 ↓

References The Journal of Biological Chemistry16/2/2018293: 2422-2437. Anal Cell Pathol (Amst). 2018; 2018: 787.1814 Nature Reviews Drug Discovery. Sep2014, Vol. 13 Issue 9, p673-691 J Cancer Res Clin Oncol. 2018; 144(6): 1065–1077.

Diabetes XXV. Obesity linked disruption of adipose mediated endocrine hormone control over fatty acid turnover from TAG leads to T2D in humans. Dr. Daniel J. Guerra. 3April22.Authentic Biochemistry 30.12.2022 29:59 ↓

References Dr. Guerra lecture materials Progress in Lipid Research Volume 74, April 2019, Pages 145-159

Holiday Ethanol Abuse Lecture I. EtoH ingestion, while intoxicating redox metabolism is also a membrane lipid -protein interacting agent that corrupts inwardly rectifying K voltage gated channels. 30.12.2022 30:00 ↓

References Dr Guerra EtOH lectures PNAS November 5, 2013 vol. 110 no. 45 Alcohol, 2017-12-01, Volume 65, Pages 51-62

ImmunoEpigeneticsIX. Promoter/Enhancer proximal and distal epigenetic signatures and transcription factor protein heterogeneity compose gene expression event ontology.DJGPhD.29.12.22.AuthenticBiochem 29.12.2022 29:54 ↓

References Proc Natl Acad Sci U S A. 2021 Nov 16; 118(46) Nat Rev Mol Cell Biol. 2021 Dec 1; 22(12): 815–833. 

More "mere" epistemology opening a door to metaphysics II. Non-canonical epi-rational and epi-empirical retailoring of understanding and imagination via research scientific endojectification.DJGPhD. 25.12.2022 24:42 ↓

References Dr. Guerra's ongoing flight into the telos of research science.

ImmunoepigeneticsVIII. Protective immunotolerant neonate Th1 inactivity involves IL-12 p35subunit promoter methylation. DJGPhD.23.12.22. Authentic Biochemistry Podcast 24.12.2022 29:54 ↓

References Trends in Immunology. REVIEW. 2017. VOLUME 38, ISSUE 4, P287-297. J Biomed Sci. 2014 Aug 19;21(1):76.

Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB. 23.12.2022 30:00 ↓

References Neural Plasticity. 2019; 2019: 1648736. Molecular Pharmacology May 2017, 91 (5) 451-463.

Holiday Ethanol Use VII. EtOH exposure precipitates chromatin methylation associated MCH and chemokine involvement linking arousal, reward and inflammation. DJGPhD.21.12.22 Authentic Biochem. 21.12.2022 29:58 ↓

References PLoS One. 2011;6(5):e17711 J Neuroinflammation. 2020; 17: 207 Front Neurosci. 2019 Nov 26;13:1280

Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast 21.12.2022 21:15 ↓

References Dr Guerra's ideas and concepts concerning the epistemics of research science . Lecture I.

Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast 18.12.2022 30:00 ↓

References Dr Guerra EtOH lectures Dr Guerra Reward Pathway lectures Biol Psychiatry. 2020 Jan 1; 87(1): 64–73 Biochemistry and Cell Biology. 2019. Volume 97, Number 4.August.

Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health. 18.12.2022 30:00 ↓

References Dr Guerra EtOH lectures Physiol Rev 2016. 96: 1261–1296. Clinical and Molecular Teratology. 2016. Volume 106, Issue 9 Pages 749–760

Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem. 17.12.2022 29:55 ↓

References Dr Guerra's EtOH lectures Cells. 2020 Sep; 9(9): 2125.

Holiday Ethanol Use III. In utero fetal cardiac muscle development is corrupted by maternal EtOH exposure via metabolic, bioenergetic and epigenetic means involving fatty acid and folate redox poise. 16.12.2022 30:00 ↓

References Dr. Guerra's EtOH lectures Clinical and Molecular Teratology 2016. Volume 106:749–760 Stat Pearls. Embryology and Gastrulation. NIH 2022. https://www.ncbi.nlm.nih.gov/books/NBK554394/

Holiday EtOH Lecture II. Ethanol ingestion permanantly corrupts myelin lipid composition while altering MET and Folate metabolism leading to epigenetic syntactic and semantic chromatin errors.DJGPhD. 14.12.2022 29:51 ↓

References Clinical and Molecular Teratology Volume 106, Issue 9 September 2016 Pages 749–760 Alcohol, 2017-12-01, Volume 65, Pages 51-62

Immunoepigenetics VII. MicroRNA mediated feedback control over signalling response toward inflammation.DJGPhD. 10Dec22. Authentic Biochemistry 11.12.2022 30:00 ↓

References Arthritis Res Ther. 2021; 23: 19. Frontiers in Immunology.  November 2014. 21(578):1

ImmunoepigeneticsV!. TLR's and TCR's use membrane lipid raft signal transduction to obtain transcription factor mediated cell fate via epigenetic modification. DJGPhD.09 Dec.22 09.12.2022 29:53 ↓

References Frontiers in Immunology November 2014. 21(578):1 Clin Epigenetics. 2017; 9: 94  Cancer Cell International September 2020. 20(1):429

ImmunoepigeneticsV. TCR activation and the integration of cell senescence with epigenetic authorship and reading-mediated tumorigenesis. DJGPhD.07Dec22. Authentic Biochemistry 07.12.2022 29:52 ↓

References Cancer Cell Int. 2022; 22: 272. Cell Mol Life Sci. 2013 Oct;70(20):3753-72 PLoS Biol. 2013 Mar; 11(3): e1001502

ImmunoEpigeneticsIV. Membrane lipid raft components dynamically mediate Tcell reception, hippocampal pyrimidal neuron endocytosis, and lung cancer cell mesenchymal to endothelial transition.DJGPhD. 05.12.2022 29:28 ↓

References Respir Res. 2017 Sep 6;18(1):168 Front Behav Neurosci. 2020; 14: 24 JLR Methods| 2020.Volume 61, ISSUE 11, P1512-1523, November 01