Authentic Biochemistry

ImmunoEpigenetics XXIX. Apoptosis unthwarted:preventing phosphorylation of RNAPOLII tanks histone acetylation near Mcl enhancer region thus epigenetically inhibiting expression in glioblastoma cells. 16.02.2023 29:52 ↓

References Cell Death & Differentiation 2020.27: 3374–3385  Cell Death & Differentiation 2019. 26: 1501–1515 Cancers  2020, 12 (8), 2137.

A Dialectic on Research Scientific Method I. How research questions may be apprehended through the hypothetico-deductive-experimental paradigm. DJGPhD. 14.2.23 14.02.2023 29:48 ↓

References Guerra: lectures on research methods

ImmunoEpigenetics XXVIII, Synthesis of epigenetically controlled ferroptosis with Cyto-Toxic T Lymphocyte APC/MHC activated IFN-Gamma induced tumor fatty acyl CoA synthase- lipid peroxide mechanism. 14.02.2023 29:33 ↓

References Cancer Cell  2020. 40, Issue 4 , Pages 365-378.e6 Circulation Research. . 2004 May 28;94(10):1318-24. Mol Cell. 2020 Jun 18;78(6):1192-1206.e10 Cell. 2012 Aug 17;150(4):685-96 Cell Death Differ. 2020 May; 27(5): 1660–1676.

Immunoepigenetics XXVII. PKM2 as an epigenetic and metabolic author of cell proliferation leading to tumorigenesis. DJGPhD. 12 Feb 2023. Authentic Biochemistry Podcast 13.02.2023 30:00 ↓

References Mol Cell. 2014 Mar 6;53(5):700-9 Mol Cell. 2015 Sep 3;59(5):850-7 Cell & Bioscience 2019.Volume 9 , Article number: 52.

ImmunoEpigenetics XXVI.The repressive deubiquitinase (PR-DUB) inhibits ubiquitinated histone 2A occupancy on SLC7A11 promoter causing cystine starvation and GSH depletion promoting ferroptosis. DJGPhD 11.02.2023 29:59 ↓

References Cell Research. 2022. volume 32, pages 687–690 .

ImmunoEpigenetics XXV. Lymphocyte Specific Helicase inhibits ferroptosis while promoting tumorigenesis via fatty acid desaturase gene transcription and subsequent oleic acid formation via CoQ10.DJGPhD 09.02.2023 29:26 ↓

References Molecular Cancer 2020. volume 19, Article number: 39.  Adv Exp Med Biol. 2021; 1301:41-57

A Biochemical Partita 7th Movement. The articulation of obesity as arbiter of pathophysiology. DJGPhD. 04Feb23. Authentic Biochemistry. 05.02.2023 29:46 ↓

References and Inspiration Dr Guerra lecture notes https://youtu.be/uubKzLxxj1s

A Biochemical Partita 6th Movement. Human bioenergetics and hormonal regulation involving FA beta-oxidation and gluconeogenesis "discourage" glyoxylate cycle molecular evolution a priori. DJGPhD. 04.02.2023 30:00 ↓

References and Inspirations Dr Guerra graduate biochemistry lectures https://youtu.be/156u4nV2uGE

A Biochemical Partita 5th Movement. The hepatic Malate Apartate Shuttle combined with the 2-oxoglutarate carrier facilitate reducing power and the OAA carbon source for cytosolic gluconeogenesis. 04.02.2023 29:50 ↓

References and Inspirations Dr Guerra's lecture notes-graduate biochemistry https://youtu.be/nP4nBxMtEug

A Biochemical Partita 4th Movement.Regulation of gluconeogenesis vs. glycolysis and the fatty acyl CoA beta-oxidation pathway provide REDOX and allosteric control over bioenergetics. DJGPhD.01FEB23. 02.02.2023 29:03 ↓

References&Inspirations Guerra intermediary metabolic lectures https://youtu.be/nDidA8_gfbU

ImmunoepigeneticsXXIV. The Cathelicidin anitmicrobial peptide cysteine protease domain may contibute to innate immune defense against cancer via epigenetically regulated ferroptosis.DJGPhD.1Feb23 01.02.2023 30:00 ↓

References Peptides . 2020 Jan;123:170177 Molecular Cancer. 2020. volume 19, Article number: 39.

A Biochemical Partita 3rd movement. Principle of Sufficient Reason and the refutation of biological reductionism. DJGPhD.31.1.23. Authentic Biochemistry Podcast Productions 01.02.2023 28:47 ↓

Inspirations https://youtu.be/XkfsGCIiHb4

A Biochemical Partita. 2nd movement. DJGPhD. 29.1.23 Authentic Biochemistry Podcast Production 30.01.2023 29:56 ↓

References Guerra lecture notes https://youtu.be/X0T6KysSejQ

A Biochemical Partita. Ist movement. DJGPhD. 28.1.23 Authentic Biochemistry Podcast Production 28.01.2023 29:53 ↓

Inspiration https://music.youtube.com/watch?v=BR1_FhZdUIM&feature=share

ImmunoepigeneticsXXIII. Vitamin D hydroxylation mediated alteration of VDR chromatin retailoring and alteration of promoter methylation generate a dialectically ontological pathophysiology.DJGPhD. 28.01.2023 29:39 ↓

References Sci Transl Med . 2015 Apr 8;7(282):282ra47 Cell Physiol Biochem . 2018;47(3):1060-1073 Hum Genomics. 2021; 15: 24

Immunoepigenetics XXII. The role of circulating vitaminD in the regulation of innate immune antimicrobial peptide generation. DJGPhD. 25.1.23 Authentic Biochemistry 26.01.2023 30:00 ↓

References Hum Genomics. 2021; 15: 24 Nutrients. 2022 Jan; 14(2): 284

ImmunoepigeneticsXXI. Methylation patterns of CpG vs histone modification of specific loci must be sequenced to verify pathophysiological events. DJGPhD. 22.1.23 Authentic Biochemistry. 22.01.2023 29:59 ↓

References Hum Genomics. 2021; 15: 24 JCI Insight. 2020 Sep 3;5(17):e138443 N ature Reviews Genetics volume 14 , pages 204–220 (2013)

A Special Message for Authentic Biochemists. A direct way to contact your host and a little more. DJGPhD.21.1.23 Authentic Biochemistry Productions. 21.01.2023 10:36 ↓

Rather than referencing this episode I am enlisting your input. Please email me at our new email address: authenticbiochemistry@gmail.com   Sincerely, Dr Guerra

Immunoepigenetics XX. Inflammatory cytokines and associated transcription factors are controlled by epigenetically regulated microRNA. DJGPhD.20.1.23. Authentic Biochemistry. 21.01.2023 29:49 ↓

References Dr Guerra's micro RNA lectures FEBS J Volume278, Issue10 May 2011. Pages 1598-1609 International Journal of Molecular Sciences 2013. 14(11):22796-22816  Front. Genet., 07 September 2021

ImmunoEpigeneticsXIX. Diet-induced and db/db mouse model Type 2 diabetes is dissimilar to the human pathophysiology but shares epigenetic mechanisms controlling pro-inflammatory PLA2/COX2/PGE2. 20.01.2023 29:58 ↓

References Dr. Guerra's lipid lectures JCI Insight. 2020 Sep 3;5(17):e138443 Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7): 4061–4065.

ImmunoepigeneticsXVIII. Variable DNA and histone methylation in cooperation with micro RNA mediate macrophage plasticity,inflammation and wound repair in T2D patients. DJGPhD.18.1.23.AuthenticBiochem. 19.01.2023 30:00 ↓

Reference JCI Insight . 2020 Sep 3;5(17):e138443

Epistemological integration into realized metaphysicsV. Energy and mass like space and time are estimations of uncertain certainties yet are used as universals in physico-chemical event ontologies 16.01.2023 30:00 ↓

References Thomas Hobbs-Leviathan Heraclitus-Collected Works

Immunoepigenetics XVII.TGF beta involvement in disease pathology and normal developmental physiology demonstrates the complexity of categorical ontologies in biochemical events.DJGPhD.13.1.23.AB 14.01.2023 29:56 ↓

References JCI Insight . 2020 Sep 3;5(17):e138443 J Clin Invest. 2022 Apr 15;132(8):e151020

ImmunoepigeneticsXVI. TGFbeta 1 and subfamily member Activin A diferentially alter the categorical valence and modality of Th17 cells in multiple sclerosis via receptor kinase modulatory specificity. 13.01.2023 30:00 ↓

References Immunity. 2021 Feb 9; 54(2): 308–323.e6. J Endocrinol. 2003 Sep;178(3):479-89.

ImmunoepigeneticsXV. In utero fetal exposure to high concentration of maternal cortisol can induce histone code hypomethylation proximal to the TGF B-1 receptor resulting in adult OA.DJGPhD.12Jan23 13.01.2023 29:51 ↓

References Stem Cell Res Ther. 2021; 12: 163 Biomedicines. 2021 Nov; 9(11): 1666