Dr Daniel J. Guerra
Authentic Biochemistry
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Dr Daniel J. Guerra
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Último episódio
29 de out de 2026
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Episódios
ImmunoEpigenetics55. ILC and Treg differentiation is mediated by acetylation and methylation epigenegtic authorship at discrete TF binding site domains.DJGPhD.14.4.23. Authentic Biochemistry 14.04.2023 28:54
References Cell Reports 2015 10, 2043-2054DOI ID2_HUMAN,Q02363 Experimental & Molecular Medicine 2019. volume 51, Article number: 80.
Immunoepigenetics 54. Macrophages, T lymphocytes and neutrophils each comply with epigenetic alterations to mediate the inflammatory response. DJGPhD.12April.2023.Authentic Biochemistry 13.04.2023 29:56
References Guerra's notes
ImmunoEpigenetics 53.The metaphysics of biochemical control within epigenetic alteration of gene expression as obtained in macrophage mediated immune activation. DJGPhD.7April23'Authentic Biochem 07.04.2023 29:43
References Dr Guerra's lecture notes-Immunology DJGPhD writings on Middle Platonist Metaphysics in Biochemistry: unpublished Curr Opin Biotechnol. 2020 Jun; 63: 111–117
ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast. 05.04.2023 30:00
References Curr Opin Biotechnol. 2020 Jun; 63: 111–117 Epigenomics. 2019. VOL. 11, NO. 68 May Front. Genet., 23 October 2018 Sec. Epigenomics and Epigenetics Volume 9.
ImmunoEpigenetics 51. The Glutamine contribution to tumor bioenergetics and lipogenesis and the role of storage TAG in macrophage pro-inflammation. DJGPhD. 29.3.23 30.03.2023 27:44
References Nature Communications 2020.volume 11, Article number: 4107. Nutrire 2016. volume 41, Article number: 14
ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD 25.03.2023 30:00
References Cell 2012 148DOI: (10.1016/j.cell.2012.01.031) Biotechnology Journal 2016. Volume11, Issue1 Special Issue: Biotech Methods and Advances: 71-79. Molecular Cancer. 2020. volume 19, Article number: 39.
ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD 23.03.2023 29:59
References Dr Guerra's lectures and spontaneous expectorations. Molecular Cancer 2020. volume 19, Article number: 39
ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23 21.03.2023 30:00
References Methods Enzymol. 2009; 457: 425–450 Endocrinology , Volume 155, Issue 5, 1 May 2014, Pages 1653–1666 Am J Physiol Endocrinol Metab. 2008 Dec; 295(6): E1287–E1297
Immunoepigenetics 47. Intermediary metabolism re-enters the discussion on tumor corruption of cell division via diversion of glucose to NADPH production.DJGPhD 18.03.2023 30:00
References Dr Guerra's lectures AJP Endocrinology and Metabolism. 2008. 295(6):E1287-97 Biochem Biophys Res Commun.1996 May 15;222(2):287-91 Carcinogenesis.2020 Jun; 41(4): 405–416 Oncogenesis 2017. volume 6, page e329.
ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23 16.03.2023 29:22
References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association. 12.03.2023 29:48
References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry. 09.03.2023 29:32
References Antioxidants (Basel). 2023 Feb; 12(2): 274 J Lipid Res. 2016 May; 57(5): 868–881. J Biol Chem. 2007 Jan 12;282(2):1384-96. J. Am. Chem. Soc. 2014, 136, 36, 12624–12630
ImmunoEpigenetics XXXXIII. In silico analysis of Rheumatoid Arthritis methylation patterns fails to obtain a general rule for epigenetic regulation of gene expression.DJGPhD07March23. ABPe 08.03.2023 30:00
References Int J Hematol 2022. 116, 828–836 Cancer Immunol Res (2022) 10 (1): 87–107 Front Immunol. 2022; 13: 881191 Nature Reviews Immunology 2018. volume 18, pages 617–634.
ImmunoEpigenetics XXXXII. T-ALL Homeobox A gene alteration of MEF2C expressional variation linked to T-cell differentiation blockade as regulated by CaMK and HDAC4/HDAC5. DJGPhD. 05March23. 06.03.2023 28:13
References Biochem J 2012 444(1):105-114 Epigenetics. 2015 May; 10(5): 418–430. Nature Reviews Immunology volume 2018. 18, pages 617–634
ImmunoEpigenetics XXXXI. From Programmed Cell Death to Homeobox gene clusters, T-ALL leukaemias involve epigenetic events. DJGPhD.05March23. Authentic Biochemistry Podcast 05.03.2023 29:52
References Genes & Diseases Available online 26 December 2022 Int J Mol Sci. 2021 May; 22(10): 5317 Haematologia 2016. Vol. 101 No. 6 June. Blood (2005) 106 (1): 274–286 Nature Reviews Immunology 2018. volume 18, pages 617–634.
ImmunoEpigenetics XXXX. Transcription factor complex permutaions combine with histone acetylomic and methylomic covalent mofications in T -ALL disease. DJGPhD. 04 March 2023. Authentic Biochemistry. 04.03.2023 29:55
References Nature Reviews Immunology volume 18, pages 617–634 (2018) Genes (Basel). 2021 Aug; 12(8): 1118.
ImmunoEpigenetics XXXIX. T cell acute lymphoblastic leukaemia genetics and epigenetics: the role of chromatin retailoring via histone LYS acetylation/deacetylation event ontology. DJGPhD.3March23 04.03.2023 29:45
References Genes (Basel). 2021 Aug; 12(8): 1118. Nature Reviews Immunology 2018. volume 18, pages 617–634.
ImmunoEpigenetics XXXVIII. Tcell receptor activation and the PIP3/AKT/mTORCI/mTORCII control over cytokine expression:a primer. DJGPhD.2March2023.Authentic Biochemistry Podcast. 03.03.2023 29:45
References Guerra's immunology lectures Experimental & Molecular Medicine volume 51, Article number: 80 (2019) Genes (Basel). 2021 Aug; 12(8): 1118
ImmunoEpigenetics XXXVII. Differential substrates for the Adenylate Cyclase-PKA phosphorylation cascade distributes assymetric inflammatory, hormonal and metabolic sequalae. DJGPhD.01March23. 02.03.2023 29:38
REferences Dr Guerra's graduate biochemistry lectures J Biol Chem. 2013 Mar 8; 288(10): 7137–7146
ImmunoEpigeneticsXXXVI. Tumor-specific methylation respondent transcription of Adenylate Cyclase 2 may be linked to differential cytokine expression controlling T cell activation. DJGPhD.01March23. 01.03.2023 29:57
References Naunyn Schmiedebergs Arch Pharmacol . 2014 Apr;387(4):329-39. J Biol Chem. 2013 Mar 8; 288(10): 7137–7146 J Anim Sci. 1998 Jan;76(1):160-72 Journal of Bone Oncology 2017. Volume 9: 34-40
Immunoepigenetics XXXIV. Methylation signatures in neoplasias1. DJGPhD. Authentic Biochemistry Podcast Productions. 26.2.23 26.02.2023 29:59
References Journal of Bone Oncology 2017. Volume 9, November. Pages 34-40 Journal of Disease and Global Health 15(3): 22-47, 2022.ISSN: 2454-1842, NLM ID: 101664146 https://www.ikppress.org/index.php/JODAGH/article/view/8023
ImmunoEpigenetics XXXIII. Crisper CAS , small molecule,and LOXP-CRE targeting of SDH/ComplexII decrease Th1 cytokine production: Standard Oxidation Potentials and TCA anapleurotic involvement.DJGPhD. 24.02.2023 29:56
References Nature. 2019 Jul; 571(7765): 403–407 Dr Guerra's lectures
ImmunoEpigeneticsXXXII. Apriori synthesis of the glycolytic/TCA/ETC axis mediating target and endogenous apoptotic control with Th and NK cell activation/proliferation and effector function. DJGPhD. 22.02.2023 29:14
References Authentic Biochemistry Podcast Immunoepigenetics lectures XXIX-XXX1 Dr. Guerra's intermediary metabolism and bioenergetics lectures Nature. 2019 Jul; 571(7765): 403–407
ImmunoEpigenetics XXXI. The role of SDH on Complex II electron flow to ubiquinone subsequent to cardiac arrest is associated neuronal PCD similar to Tcell bioenergetic switching during activation. 19.02.2023 30:00
References J of Intensive Care. 2020. volume 8, Article number: 60. Neuroscience. 2018 Nov 21;393:24-32 Cancers 2020, 12(11), 3237 Nature. 2019 Jul; 571(7765): 403–407
Immunoepigenetics XXX.NK lymphoyctes programed tumor cell death by titrating anti-apoptotic BCL proteins with BH3 pro-apoptotic events. DJGPhD. 17.2.23. Authentic Biochemistry Podcast 18.02.2023 29:59
References Cancers (Basel). 2020 Aug; 12(8): 2137. Cell Death Dis. 2020 Jan 2;11(1):5 Cell. 2022. 185. 9. :521-1538.e18
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