Dr Daniel J. Guerra
Authentic Biochemistry
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Dr Daniel J. Guerra
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Último episódio
29 de out de 2026
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Episódios
ImmunoEpigenetics 75. Sphingolipid receptor molecular discernment from exosome cargo mediated control involves M1 to M2 polarization shift post myocardial infarction induced fibrosis. DJGPhD.6June23 06.06.2023 30:00
Reference The International Journal of Biochemistry& Cell Biology Volume 114, 105564.
ImmunoEpigenetics74.The methylation-specific epigenetic control over adipose tissue macrophage polarity is axially supported by leptin induced CNS control over satiety and pancreatic insulin secretion 05.06.2023 30:00
References JCI Insight. 2016 Nov 17; 1(19): e87748. Graduate Biochemistry lecture archives-Guerra Nutrition. 2020 Oct;78:110935.
ImmunoEpigenetics 73. The dialectical synthesis of adipose PPAR-gamma mediated fatty acid binding protein4 expression in foam cell formation and subsequent adipokine contribution to insulin secretion 05.06.2023 29:42
References Cells. 2019 Mar; 8(3): 227 Chest. 2016 Jul; 150(1): 91–101 JCI Insight. 2016 Nov 17; 1(19): e87748.
ImmunoEpigenetics72. Chemistry of reactive oxygen/nitrogen radical species as adipose pathobiochemical sequalae to obesity via M1 macrophage polarity involving adipose and vasculature pathophysiology. 03.06.2023 29:46
References Inn Med (Heidelb). 2023 Apr;64(4):313-322 JBC 2001.Volume 276, Issue 31, Pages 28799-28805 Frein, Daniel. 2006. “Signaling and Redox Regulation by Nitric Oxide, Superoxide and Carbon Monoxide.” Hypertension. 2002;39:1088–1094 Nat Metab. 2022 Sep;4(9):1202-1213 JCI Insight. 2016 Nov 17; 1(19): e87748
ImmunoEpigenetics 71. Insulin receptor corruption is mediated by high circulating fatty acids, in situ DAG-PKCepsilon induced phosphorylation and membrane protein aggregation in obese diabetics.DJGPhD 02.06.2023 26:34
References Guerra Biochemistry lecture archives Nat Metab. 2022 Sep;4(9):1202-1213 Mol Cell. 2008 May 23; 30(4): 403–414 J Clin Invest. 2016 Nov 1; 126(11):4361–4371. Front Immunol. 2021; 12: 746151.
ImmunoEpigenetics 70.Obesity-linked adipose resident macrophage (M1)polarization meta-inflammation leads to Insulin Resistance via fatty acid oxygenation in situ. DJGPhD.01June2023.Authentic Biochem. 02.06.2023 29:36
References Graduate Biochemistry lectures-Guerra Front Immunol. 2021; 12: 746151
Intermediary Metabolism Lecture. Covalent modification of enzymes and transcription factors alter bioenergetics and the pro-inflammatory response in obese vs. healthy patients.31.5.23 DJGPhD 31.05.2023 29:53
References Guerra general graduate biochemistry lecture Immunol Res. 2020 Feb;68(1):28-38. doi: 10.1007/s12026-020-09125-9.
See the youtube video in the show notes 26.05.2023 1:28
https://youtu.be/es0RrQHHXl0
ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency. 25.05.2023 30:00
References Journal of Experimental & Clinical Cancer Research 2022.volume 41, Article number: 303. Protein Cell. 2021 Apr; 12(4): 240–260. J Cell Biol (2022) 221 (11): e202202011.
Graduate Biochemistry Lecture III. Dietary lipid control over neuroendocrine system involves multiple organ systems in contact with immune surveilance. DJGPhD. 24.5.23B Authentic Biochemistry 24.05.2023 29:53
References Dr. Guerra's lecture archives.
Graduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23. 24.05.2023 29:59
References Dr. Guerra's lipid lectures J Diabetes Investig. 2019 Nov; 10(6): 1430–1437.
Special Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23. 20.05.2023 29:40
Reference Dr Guerra: Graduate Biochemistry lecture material.
ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters 18.05.2023 29:59
References Arterioscler Thromb Vasc Biol . 2021 Jan;41(1):153-166. Clinical Epigenetics 2021. volume 13, Article number: 7. https://www.sciencedirect.com/topics/immunology-and-microbiology/foam-cell
ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD 16.05.2023 29:53
References JLR 2014 55(6) Pages 1165-1172. JLR 2018 59(6): 1058–1070.
ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD. 16.05.2023 29:49
References PLoS ONE 2012. 7(4): e3440 Steroids 2021. Volume 172, August, 108854 Antioxidants 2019, 8(5), 126
ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis. 14.05.2023 30:00
References Free Radical Biology and Medicine Volume 71, June. Pages 1-15 Cardiovasc. Res. 2012 May 1; 94(2): 379–390. Int. J. Mol. Sci. 2020, 21 (7), 2578; https://doi.org/10.3390/ijms21072578
ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means 12.05.2023 30:00
References Free Radical Biology and Medicine 2014. Volume 71, June. Pages 1-15 J Mol Endocrinol. 2020 Nov; 65(4): R77–R90. REDOX and Cholesterol metabolism lectures-Dr Guerra
ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites 10.05.2023 29:19
References Cancers (Basel). 2019 May; 11(5): 678. Oncogene.2017 Mar 23; 36(12): 1607–1618 Dr Guerra's annotated lecture notes from graduate biochemistry course(s)
ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD 10.05.2023 29:50
References Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9 Cancer Drug Resist 2020;3:762-74. Oncogene.2017 Mar 23; 36(12): 1607–1618 Front Immunol. 2020; 11: 1782.
ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability. 09.05.2023 29:59
References Dr Guerra Intermediary metabolic lecture notes-graduate biochemistry lecture archives Epigenetics. 2019; 14(12): 1183–1193. Drug Discov Today. 2017 Jan; 22(1): 186–193.
Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast 07.05.2023 29:38
References Int J Mol Sci. 2020 Jun; 21(11): 4098.
ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23 06.05.2023 29:47
References Int J Mol Sci. 2020 Jun; 21(11): 4098. Authentic Biochemistry lectures :ImmunoEpigenetics 56-58
ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSG's advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem. 28.04.2023 29:53
References BMC Medical Genomics. 2015. volume 8, Article number 45. Journal for ImmunoTherapy of Cancer 2022;10:e003826.
ImmunoEpigenetics 57. Plasmacytoid dendritic cell neoplasias and the CAR-T cell tumor microenvironment exposure altering epigenetic TF regulation leading to diverse differentiation. DJGPhD.20.4.23 21.04.2023 30:00
References Current Oncology Reports. 2020. 1534-6269, May 15, Vol. 22, Issue 6. Cell. 2021 Dec 9; 184(25):6081–6100.e26.
ImmunoEpigenetics 56. Dendritic cell immunobiochemistry introductions. DJGPhD. Authentic Biochemistry 15.4.23 15.04.2023 28:37
References Autoimmunity. 2012 Aug;45(5):333-47 Clinical and Experimental Rheumatology 2019: One year in review 2019: systemic lupus erythematosus Trends in Immunology, 2021-01-01, Volume 42, Issue 1, Pages 59-75 Annu. Rev. Immunol. 2000. 18:767–811
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