Authentic Biochemistry

Photosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productions 06.07.2023 29:53 ↓

Guerra: Plant biochemistry Lectures

Unique Lecture Post holidayIV. Photosynthesis 2. DJGPhD.05July23b Authentic Biochemistry Podcast production. 05.07.2023 30:00 ↓

References Plant Biochemistry Lectures -Guerra

Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast. 05.07.2023 30:00 ↓

References Guerra. Plant Biochemistry lectures

Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions) 04.07.2023 29:54 ↓

Reference Organic chemistry : reaction mechanism lectures

Unique Lecture Series . Holiday Time. 4th of July 2023! Hydrocarbons. 01.07.2023 30:00 ↓

Very basic lecture material

ImmunoEpigenetics 89. Final synthesis of statin drug mediated alteration of metabolism in T lymphocytes. DJGPhD.6.30.23. Authentic Biochemistry Podcast. 30.06.2023 29:56 ↓

References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Previous 5 lectures in Authentic Biochemistry and refs. contained therein https://youtu.be/dyy0p90GO2w

ImmunoEpigenetics 88. Statin treatment of early progenitor T cell acute lymphoblastic leukemia could pose biochemical impositions on healthy lymphocyte populations. DJGPhD.29.6.23.Authentic Biochem. 30.06.2023 29:56 ↓

References Oncotarget 2021.12.(13) Cancers (Basel). 2020 Aug 1;12(8):213 Cancer Discov. 2022 Mar 1; 12(3): 856–871

ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture. 28.06.2023 29:58 ↓

References JBC.2002. Volume 277, ISSUE 2, P1128-1138. Cancer Discov. 2022 Mar 1; 12(3): 856–871. Guerra lectures-lipid metabolic regulation Guerra lectures-pharmacodynamics and kinetics

ImmunoEpigenetics86. Could regimented titrating statin pharmacotherapy be useful in controlling early T lymphoid progenitor cell ETP-ALL via an epigenetic mechansim? DJGPhD.27.6.23. Authentic Biochem 28.06.2023 28:53 ↓

Reference Cancer Discov. 2022 Mar 1; 12(3): 856–871.

ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23 25.06.2023 28:50 ↓

References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Sci Signal. 2015 Mar 31;8(370):re4

ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD. 24.06.2023 29:43 ↓

References J Exp Med. 2017 Jul 3;214(7):1861-1876 Immunol Rev. 2014 Sep;261(1):62-83 Int J Mol Sci. 2022 Mar; 23(5): 2878. Immunity 2022. Volume 55, Issue 8. :1402-1413.e4

ImmunoEpigenetics 83. Epistemic and metaphysical considerations of immune cell epigenetic reprogramming obtaining biochemical event ontologies. DJGPhD.23.6.23. Authentic Biochemistry Podcast 23.06.2023 30:00 ↓

References Guerra: logical propositions and dialectical syntheses Annual Review of Immunology2021. Volume 39: 279-311

ImmunoEpigenetics82.Innate lymphoid progenitor antibody-directed single cell DNAse hypersenitive site analysis of transcription factor specific histone methylation and acetylation modifications.DJGPhD 23.06.2023 29:17 ↓

References Nat Protoc. 2017 Nov;12(11):2342-2354 Annual Review of Immunology 2021. Volume 39. pp 279-311 Immunity 2022. Volume 55, Issue 8. Pages 1402-1413.e4

ImmunoEpigenetics 81.Innate lymphoid cells lack antigen receptors and are differentiated into multiple linneages via epigenetic priming of nucleosomal regions proximal to cell-specific TF's.DJGPhD. 22.06.2023 30:00 ↓

References Immunity 2022. 55, Issue 8. Pages 1402-1413. Methods Mol Biol. 2018;1675:167-181. Experimental & Molecular Medicine 2019. volume 51, Article number: 80. Cell Reports 2015 10, 2043-2054DOI: (10.1016/j.celrep.2015.02.057)

ImmunoEpigenetics80.T lymphocyte biochemical communications are triggered epigentically and via membrane lipid molecular species recombination: A dialectical event ontological view. DJGPhD.17.6.23 18.06.2023 30:00 ↓

Reference Authentic Biochemistry Lecture synthesis

ImmunoEpigenetics79. T lymphocyte DPPA induced HSP27 deoligomerization-activating DGK-a associated anergy is linked to cancer cell proliferation phenotypes. DJGPhD.16.6.23b Authentic Biochemistry 17.06.2023 29:50 ↓

Reference J BiolChem. 2023 Mar; 299(3): 103019.

ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast 16.06.2023 29:50 ↓

References J Biol Chem 2017 292: 20481. Critique if Pure Reason.1781. Kant,I. Guerra,2023. manuscripts in preparation

ImmunoEpigenetics77. T cell membrane phospholipase D mediated PA deprotonation as a biosensor for an electrostatic/hydrogen-bond signal transductionDJGPhD.15.6.23. Authentic Biochemistry Podcast. 16.06.2023 28:46 ↓

References The Journal of Biological Chemistry 2007.282,11356-11364. BMC Biology 2011. 9:85 Cancer Res . 2011 Jan 15;71(2):293-7. J BiolChem. 2023 Mar; 299(3): 103019.

Interum lecture VI. Entropic forces and the ergodic hierarchy of GPCR-linked phsopholipase phase space postioning temporality. DJGPhD.13.6.23 14.06.2023 29:47 ↓

References ACS Omega. 2019 Nov 26; 4(22):19526–19547 Guerra: general thermodynamics lectures

Interum Lecture V. Semi-closure on free energy and enthalpic involvement in leptin/AMPK mediated orexigenic states . DJGPhD.12June23.Authentic Biochemistry Podcast 12.06.2023 29:49 ↓

Reference Guerra lecture material

Interum Lecture IV. MBD:DNAMolecular Dynamics video lecture! 12.06.2023 1:07 ↓

https://youtu.be/O2CpwFLy0zI

Interum Lecture III. Protein methylation binding domain association with substrate CpG alters equilibrium torsion angle (epsilon-zeta) conformational states via enthalpic-free energy conservation. 11.06.2023 29:57 ↓

References Mol Informatics. 2012 Feb;31(2):114-22. Nat Struct Mol Biol. 2017 Jun; 24(6):544–552 Guerra: chemical thermodynamics lectures

Interum Lecture II. Rates of reactions in living systems.DJGPhD.8June2023 Authentic Biochemistry Podcast 09.06.2023 30:00 ↓

References Guerra-lecture notes and marginalia

Interrum lecture I. Obesity unsuccessfully violates the first law of thermodynamics. 07.06.2023 30:00 ↓

References Guerra: Faculties of reason

ImmunoEpigenetics 76. Sphingolipid metabolism and S1P receptor expression linked to multiple potentiating immunoinflammatory obese associated pathophysiologies. DJGPhD.6June23B AuthenticBiochemistry 07.06.2023 29:13 ↓

References Dr. Guerra-graduate lipid lectures Nutrients.2022 Jun 12;14(12):2438 Endocrinology. 2006 Dec;147(12):5835-44 The International Journal of Biochemistry & Cell Biology 2019. Volume 114, 105564