Authentic Biochemistry

BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD 09.08.2023 29:03 ↓

References Mol Neurobiol 2020 Jun; Vol. 57 (6), pp. 2654-2670 Brain Res. 2009 Sep 22; 1290: 1–11. JAMA.2003;289(20):2651-2662.

Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB. 08.08.2023 29:55 ↓

References JAMA.2003;289(20):2651-2662. Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Psychiatry. 2019 Sep 15;86(6):421-432

BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection. 07.08.2023 29:59 ↓

References Essays Biochem. 2021 Nov; 65(6): 913–925 Front. Endocrinol. 2022. AUGUST. v.13 .Sec. Molecular and Structural Endocrinology

BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23 05.08.2023 29:59 ↓

Reference Essays Biochem. 2021 Nov; 65(6): 913–925

BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23 05.08.2023 30:00 ↓

References Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Sex Differ. 2023; 14: 34.

BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry 03.08.2023 30:00 ↓

References Biol Sex Differ. 2023; 14: 34 J Cell Sci 2005;118:4605-4612 EBioMedicine. 2015 Dec; 2(12): 1888–1904 PLoS Genet. 2013 Jun; 9(6): e1003556

From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast 31.07.2023 29:31 ↓

Reference Some light on the forest floor of wisdom

The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast 30.07.2023 30:00 ↓

References Experience et al.

ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry 30.07.2023 29:30 ↓

References Mol Cancer. 2023 Apr 10;22(1):69 Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415 Semin Immunol. 2010 Dec; 22(6): 311–312

ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast. 28.07.2023 30:00 ↓

Reference Front Immunol.2022; 13: 890056. previous IE lectures 1-3.

ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD 27.07.2023 29:30 ↓

Reference Cancers (Basel). 2021. Apr; 13(8): 1850.

ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression. 26.07.2023 29:59 ↓

References NPJ Vaccines. 2018; 3: 23. Immunol Cell Biol. 2022 Aug; 100(7): 562–579

ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23 24.07.2023 29:56 ↓

References Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234. Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195

ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23 23.07.2023 29:18 ↓

References J Immunol. 2014 Aug 15; 193(4): 1531–1537 Immunology lecture notes-Guerra

Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast. 23.07.2023 29:29 ↓

Inspirations A hot summer day and what passes as a ponder on the asymmetric.

ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23 20.07.2023 29:59 ↓

Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579.

ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry 20.07.2023 28:31 ↓

Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579.

ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA. 19.07.2023 30:00 ↓

References Signal Transduction and Targeted Therapy 2021.volume 6, Article number: 412. Nature Immunology. 2022. volume 23, pages 1208–1221.

ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD. 17.07.2023 30:00 ↓

References J Biol Chem. 2021 Jul;297(1):100900 Immunol Rev. 2014 May; 259(1):88–102.

ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry. 15.07.2023 29:59 ↓

Reference Nature Immunology 2022. volume 23, pages 1208–1221.

ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry 11.07.2023 29:16 ↓

References Nature Immunology 2022. volume 23, pages 1208–1221 Signal Transduction and Targeted Therapy 2021. volume 6, Article number: 412.

Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast. 10.07.2023 29:47 ↓

References Guerra lectures archives

Primer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast Productions 09.07.2023 30:00 ↓

Dr Guerra lecture notes

PhotosynthesisV. Photorespiration and synthesis of this holiday arc: fait accompli. DJGPhD.08July23b. Authentic BiochemistryPodcast. 09.07.2023 29:59 ↓

References Guerra's plant biochemistry lectures

Photosynthesis 4. Chlorophyll and carotene biosynthesis and some further detail on the mechanism of the Mn-H20 splitting complex of p680 PSII and diatomic molecular oxygen (O2) evolution.DJGPhD. 7July 08.07.2023 30:00 ↓

References Plant Biochemistry lectures archives :Guerra Phys. Chem. Chem. Phys., 2020,22, 7912-7934 Nature Plants 2017. volume 3, Article number:17041