Authentic Biochemistry

Biochemical Energetics. Elementary Considerations chapter2. DJGPhD. 13.9.23 Authentic Biochemistry Podcast 13.09.2023 29:20 ↓

References Biochemistry lectures: Guerra archives

Biochemical Energetics I Elementary Considerations. DJGPhD 12Sept23. Authentic Biochemistry Podcast. 12.09.2023 30:00 ↓

References Biochem lecture notes

BioMedical Portrait II. Hashimoto's Thyroiditis prevalence in women linked to mitochondrial electron transport chain activity, ATP/ADP translocation, and potent autoantibodies to thyroid peroxidase. 10.09.2023 30:00 ↓

References Journal of Immunology Research Article ID 8263829 JAMA. 2021 Jun 15; 325(23): 2392–2393. Thyroid. 2014 Feb 1; 24(2): 371–382. Pol Arch Intern Med. 2022 Mar 30; 132(3): 16222. FEBS Letters.1997. (414): 258-262

BioMedical Portrait II. c.14. Predominance of Hashimoto's Thyroiditis in Women: is there a link to the decreased expression of TLR7 and the AMPK-alpha/Id3 axis on CD8+TE and Treg activity? 10.09.2023 29:59 ↓

References Mozart - Flute and Harp Concerto in C, K. 299 J Immunol Res. 2021; 2021: 8263829. J Immunol. 2022 Jan 1;208(1):155-168 Front. Immunol. 2022.31 March. Sec. Molecular Innate Immunity Volume 13 –202. Cells. 2022 Mar; 11(6): 997 Nature Immunology 2020. volume 21, pages1256–1266. Nature Immunology 2011. 12 (12) 10.

BioMedical PortraitII. c13. Female prevalent autoimmune RA-macrophage STAT3(TF) and NaMPT(NAD+ salvage pathway) promote rheumatoid arthritis & primer on thyroiditis 09.09.2023 30:00 ↓

References Cells. 2022 Mar; 11(6): 997. Nat Cell Biol. 2019 Mar; 21(3): 397–407. Rheumatology (Oxford). 2023 Jul; 62(7):2611–2620

BioMedical Portrait II. C12. Lupus is far more common in women than men due to TLR7 enhancement and Rheumatoid Arthritis is more common in women due to macrophage bioeneregtic phenomenaDJGPhD.7Sept23 08.09.2023 30:00 ↓

References Rheumatology (Oxford). 2023 Jul; 62(7):2611–2620 Science Immunology.2018.26 Jan Vol 3, Issue 1. Nature. 2020 Jun; 582(7813): 577–581.

BioMedical Portrait II.c11. Autoimmune diseases like lupus are far more prevalent in women due to the lack of X chromosomal allelic inactivationof TLR7's. DJGPhD.7Sept23.Authentic Biochemistry. 07.09.2023 30:00 ↓

References Nature. 2020 Jun; 582(7813): 577–581 Science Immunology 2018.26 Jan Vol 3, Issue 1

Biomedical Portrait!!,c.10 Older women have more reactive oxygen and fewer functional mitochondria and DNA content than older men or younger women.DJGPhD.5Dept2023. Authentic Biochemistry Podcast. 05.09.2023 30:00 ↓

Reference The Journals of Gerontology: 2019. Series A,Volume 74, Issue 12, Pages 1887–1895

BioMedical Portrait II. c9. Autoimmune diseases are more common in women than men: immune response triggering and the possible role of bioenergetics.DJGPhD.3sept23.Authentic Biochemistry. 03.09.2023 29:57 ↓

References Endocrinology. 2012 Jun; 153(6):2544–2550. Redox Biol. 2020 Apr; 31: 101482

BioMedical Portrait II. C.8. Alterations in sphingosine metabolism linked to breast cancer staging in women and progression of NAFLD to NASH and HCC is much lower in women until menopause.DJGPhD. 02.09.2023 30:00 ↓

References Lipids 3 May 2022. Volume57, Pages 183-195 Front Immunol . 2023; 14: 1116839 Mol Metab. 2022 Aug; 62: 101523 Nature Reviews Molecular Cell Biology 2018. volume 19 , pages 175–191

Biomedical Portrait II. C.7. Serum sphingolipid molecular speciation in women differs from men but association with tissue endomembranous lipid components fail to be addressed.DJGPhD. 31.8.23 31.08.2023 29:57 ↓

References Aging (Albany NY). 2019 Jan 15; 11(1):73–88.

BioMedical Portrait II. Metabolic and Bioenergetic distinction between men and women includes lipid deposition and utilization mechanisms.DJGPhD.30.8.23.Authentic Biochemistry Podcast. 30.08.2023 29:50 ↓

References Front. Endocrinol.2015 Sec. Clinical Diabetes Obes Sci Pract. 2017 Mar; 3(1): 106–114.

BioMedical Portrait II, c.5. Muscle fibre sexual dimorphism obtains networks of genetic, epigenetic, and biochemical events.DJGPhD.29.8.23 Authentic Biochemistry Podcast 29.08.2023 29:54 ↓

Reference BMC Genomics. 2022; 23: 519

Biomedical PortraitII.C.4 THe sexual dimorphism of bioenergetics: introduction to carbon utilization. Video lecture link 28.08.2023 1:37 ↓

https://youtu.be/llYhGi1XSvU

BioMedical Portrait II. Chapter 3. Mitochondrial gene expression, lipid metabolism and cell fate are at least partiatially mediated by Fragile X protein competency. DJGPhD.24.8.23 24.08.2023 30:00 ↓

References Scientific Reports 2015.volume 5,Article number: 15292 Dev Cell. 2023 Apr 10;58(7):597-615.e10

BioMedical Portrait II. The Fragile X Syndrome. Discovery and subsequent association with the FMR1 gene. Premature Ovary Failure I vs. heritable intellectual disabilities DJGPhD.22.8.23 23.08.2023 30:00 ↓

References Genes & Immunity 2021. volume 22, pages 125–140. Prz Menopauzalny. 2017 Jun; 16(2):51–56. J Neuroinflammation. 2016 May16;13(1):109. Am J Physiol Cell Physiol 2022. 322: C125–C135 Adv Human Genetics 1983.13:83 Ann NY Acad Sci . 1986. 477:129 Neurol Neurosurg Psychiatry.1943. 6:154

BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation 21.08.2023 29:55 ↓

Reference J Hum Evol. 2022 Oct; 171: 103229.

BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23 19.08.2023 30:00 ↓

References Immunity 2021. 54, 2273–2287 Front Immunol. 2020. 11: 784

Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP. 18.08.2023 29:54 ↓

__ [Mol Neurobiol] 2020 Jun; Vol. 57 (6), pp. 2654-2670 Oncol Rep. 2023 May;49(5):93

BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD 17.08.2023 29:56 ↓

References Steroids. 2022 Sep;185:109053 Trends Neurosci. 2015 Jun; 38(6): 364–374 Progress in Molecular Biology and Translational Science Volume 168.Pages 257-275 Histol Histopathol. 2018 Jan; 33(1): 1–10.

BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry 16.08.2023 30:00 ↓

References Histol Histopathol. 2018 Jan; 33(1): 1–10 J Steroid Biochem Mol Biol. 2022Feb;216:106040 Steroids. 2022 Sep;185:109053

BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD. 14.08.2023 30:00 ↓

References J Steroid Biochem Mol Biol. 2022. Feb;216:106040. Steroids. 2022 Sep;185:109053

BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23 14.08.2023 28:35 ↓

References Alzheimer's Research & Therapy 2021. volume13, Article number: 56. Progress in Molecular Biology and Translational Science 2019. Volume 168 #

BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD 13.08.2023 29:59 ↓

References Genes & Immunity 2021 volume 22, pages 125–140 Arch Endocrinol Metab. 2022 Jan-Feb; 66(1): 77–87 Essays Biochem. 2021 Nov; 65(6): 913–925

BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD. 11.08.2023 29:57 ↓

Reference Journal of Cognitive Neuroscience (2022)34 (8): 1500–1520