Dr Daniel J. Guerra
Authentic Biochemistry
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Dr Daniel J. Guerra
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Último episódio
28 de out de 2026
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Episódios
BioMedical Portrait VIII. c.1 Leukotrienes: an Introduction. Dr Daniel J. Guerra. 26.12.23 Authentic Biochemistry Podcast. 27.12.2023 29:58
References J Periodontol, 2007. August 1. 78(8): 1620-6. Annu. Rev. Pharmacol. Toxicol. 2023. 63:407–28 Acta Derm Venereol. 2017; 97: 922–927 Moody Blues 1967.Nov10. Days of Future Passed. https://youtu.be/uZCzH8q1hcY?si=2cWl06wuBC4itE1k
Christmas Eve Special:Research science relies on the means by which it is apprehended thus continuously challenged and improved with the goal of finding truths about nature in perpetuity.DJGPhD 25.12.2023 27:51
References Guerra's epistemology and metaphysics :brief sketch Baroque Christmas Concert with works by Bach, Handel and Mozart Freiburg Baroque Orchestra https://youtu.be/3VupBizhIn4?si=jBOcxwesBtMPv_I1
Dyslipidaemia Coda IV. Antinomies and paralogisms in discerning apoplipoprotein contribution to HTG vs.CAD. DJGPhD.21.12.23.Authentic Biochemistry. 21.12.2023 29:51
References Biomolecules 2021, 11(7), 1016 Journal of Clinical Lipidology Volume 16, Issue 4, July–August Pages 472-482 Schubert. F. 1825. Symphony No. 9 in C major , D 944, https://youtu.be/Ip06DEeY_U8?si=pP8NP22m9XXmpz7z
Dyslipiaemia Coda III. The proposed use of apolipoprotein serum concentration and hyperTAG may require a deeper analysis at the transcriptomic and proteomic levels. DJGPhD.20.12.23 Authentic Biochem. 21.12.2023 30:00
References Biomolecules 2021, 11(7), 1016 Journal of Clinical Lipidology Volume 16, Issue 4, July–August Pages 472-482 Lennon-McCartney 1964. If I Fell https://youtu.be/F_80s6S_7Vw?si=PmlyAATePHfqmzqv Lennon-McCartney. 1963. Misery.https://youtu.be/qhbcN3ew9z0?si=DvePBioaAgZ7_dRW Alexander. A. 1962. Anna. Cover by the Beatles. https://youtu.be/b3zNKWyLfus?si=kEaNqNy_JF_HZNji
DYSLIPIDAEMIA CODA II. Hypertriacylglycerolaemia is linked to mutations in LPL and various apolipoproteins linking CAD to TAG. 18.12.23. DJGPhD.Authentic Biochemistry 18.12.2023 29:49
References Journal of Clinical Lipidology. 2022. Volume 16, Issue 4, July–August. Pages 472-482. Guerra. 2023. -Lecture notes JLR. 2012. Volume 53, Issue 9 , September. Pages 1783-1799 Mozart, WA. 1782 Serenade No12 C.Minor. K388/384a https://youtu.be/xOaP9G-9wi8?si=CE8d9hcuUfbaqa4z
BioMedical Portrait VII. C.7. Lipoprotein biosynthesis and apolipoprotein structure. DJGPhD. 16.12/23. Authentic Biochemistry 16.12.2023 29:59
References Dr Guerra-lecture notes Journal of Clinical Lipidology2022.Volume 16, Issue 4, July–August Pages 472-482
BioMedical Portrait VII.c.6 Lipoprotein Lipase regulation performs a critical role in lipid homeostasis as evidenced by chylomicron clearance resistance in obese dyslipidaemic adolescents and adults. 14.12.2023 30:00
References Nutrients. 2021 Jan 28;13(2):413 Nutrients. 2022 Jun 12;14(12):2438 J Diabetes Investig. 2023 Oct;14(10):1148-1156 Clinica Chimica Acta 2020. Volume 508, September Pages 61-68 Vivaldi. A. 1715. Gloria RV.589 https://youtu.be/XxwtYIKI9dE?si=ksQHEkQf5OlBpHCR
BPVII.c.5 Diminished circ.LPL and adiponectin in obese adolescents correlates with higher dyslipidaemic T2D, MetSynD, and insulin resistance via inflammation-triggering lipoprotein non-clearance. 12.12.2023 30:00
References Nutrients. 2021 Feb; 13(2): 413. Advances in Clinical Chemistry Volume 64 , 2014, Pages 117-177. Front Physiol. 2020; 11: 796. Int J Mol Sci. 2023 Sep; 24(18): 13942. J Diabetes Investig. 2023. Oct;14(10):1148-1156. Nutrients. 2022 Jun 12;14(12):2438 RNA Biol. 2023; 20(1): 737–749. Clinica Chimica Acta Volume 508, Pages 61-68 Kirwan, Danny. 1971. "Sands of Time" Fleetwood Mac...
BioMedical Portrait VII. C.4 Chylomicron associated endothelial luminal LPL differential interaction with ANGTPL isoforms reults in unique TRL disposition. DJGPhD.10Dec23 11.12.2023 29:59
References J Diabetes Investig. 2023Oct;14(10):1148-1156 J Pediatr. 2021 Apr; 231: 200–206.e1. Front Physiol. 2020; 11: 796. ClinicaChimicaActa.2020 Volume 508, September Pages 61-68 Mozart,WA. 1787. Eine kleine nachtmusik K.525 https://youtu.be/nPbxIT9W1AY?si=mgzBQzpvuFzsVNtB
BioMedical Portarit VII. c.3. Introduction to chylomicron apoB48 and the angiopoietin-like LPL inhibitor contributions to circulating TAG. DJGPhD.9DEC23. authentic Biochemistry 09.12.2023 29:56
References Am J Physiol Endocrinol Metab. 2021 Oct 1; 321(4): E493–E508. Clinica Chimica Acta Volume 508, September Pages 61-68 Advances in Clinical Chemistry Volume 64, Pages 117-177 Pancreas. 2017 Aug; 46(7): 874–879 Mozart WA 1775 Violin Concerto in G major, K. 216 https://youtu.be/j7Z6gouAVCc?si=X-3AnGtJoVvf7aF9
BioMed Portrait VII. c.2 Lipoprotein lipase mediated TAG delivery and adolescent obesity. DJGPhD.6Dec23. Authentic Biochemistry 07.12.2023 29:33
References Clin Chim Acta . 2020 Sep:508:61-68 Applied Physiology, Nutrition, and Metabolism .2021. Volume 46, Numbe r 8.
BioMedical Portrait VII. Lipoprotein Lipase Pathobiochemistry. Prolegomena. DJGPhD. 5Dec23 Authentic Biochemistry 06.12.2023 30:00
References J Diabetes Investig.2019 Nov; 10(6): 1430–1437.
Bio Med Portrait. c.16. NK cells promote the inflammatory court in NAFLD via mutations in lipid metabolism and excessive GK mediated glycolysis and lipogenesis in hepatocytes DJGPhD.3Dec23b 04.12.2023 29:40
References Front. Immunol., 21 August 2019 Sec. Cancer Immunity and Immunotherapy Volume 10 Front Immunol. 2021; 12: 640869 PLoS One. 2014; 9(2): e87523 Vivaldi, A. 1719. "L 'inverno". https://youtu.be/pCqO-0339k0?si=k5xtuT8x7SfJeLok
BioMed Portrait VI.C.15 Characterization of four lipid and glucose metabolic polypeptides linked to obesity/T2D and NASH-->HCC.DJGPhD.3Dec23.Authentic Biochemistry Podcast 03.12.2023 30:00
References Guerra-intermediary metabolic lecture archives ProcNatl Acad Sci U S A. 2014 Jun 17; 111(24): 8913–8918 Nutrition, Metabolism and Cardiovascular Diseases, 2023-09-01, Volume 33, Issue 9, Pages 1785-1796. Int J Cancer. 2019 Feb 1;144(3):533-544
BioMedical PortraitVI.C.14.Liver NK cell chemokine recruitment and the significant role of obesity in possible immunotoxicity in HCC ontogeny.DJGPhD.30.11.23 01.12.2023 30:00
References Journal of Hepatology 2012 56, 704-713DOI Eur J Immunol. 2019 Jan;49(1):38-41 Front Immunol. 2016; 7: 19. Immun Ageing. 2020; 17: 16. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24): 8913–8918. Cells. 2021 Jun; 10(6): 1332
BioMedical PortraitVI.c.13. Senescense and the aging of cells within systems apprehends the event ontologies of the stress phenomena-immune surveillance axis.DJGPhD.29.11.23. Authentic Biochemistry. 30.11.2023 30:00
References Annual Review of Pathological Mechanisms of Disease 2010. 5:99-118. Immun Ageing. 2020; 17: 16 Williams, Hank.1949. ISLICC. https://youtu.be/4WXYjm74WFI?si=mhYowh4ClIOKmgVX
BioMedical Portrait VI. c.12. Obesity and viral infection-associated NK malfunction may lead to NASH and subsequent HCC. DJGPhD.28.11.23. Authentic Biochemistry 29.11.2023 30:00
References Ann. Review of Pathological Mechanisms of Disease2010.5:99-118. Nature 2013 Jul 4;499(7456):97-101. Front Immunol. 2018; 9: 476 Cells. 2021 Jun; 10(6): 1332 Nat Rev Gastroenterol Hepatol (2023). https://doi.org/10.1038/s41575-023-00846-4
BioMedical Portrait VI. c.11 NK cell involvement in HepatoCellular Carcinoma. DJGPhD. 26.11.23. Authentic Biochemistry 27.11.2023 30:00
References Front Immunol. 2018; 9: 476 Nature Reviews Gastroenterology & Hepatology 2023. 20 : 662–678 (2023) Cells. 2021 Jun; 10(6): 1332. Traffic, (Traditional. arr. S Winwood )1970. "John Barleycorn Must Die" https://youtu.be/icyPFsIcAV0?si=XSVxsiojZBrwGPx6
"The Universe by Negation" DJGPhD.23.11.23 24.11.2023 28:26
References Dr Guerra's Metaphysics notes Schubert, F. 1828. Quintet in C. Major D.956 https://youtu.be/Dc3iX7x73JY?si=j4jlU4ra_488pAuE
BioMedical Portrait VI.c.10.Alterations in the cytotoxic immune response can be dissociated from inflammation via intermediary metabolic mutation.DJGPhD.22.11.23. Authentic Biochemistry Pootdcast. 23.11.2023 30:00
References Front Immunol. 2023; 14: 1151166. Dr Guerra: Biochemistry lecture archives Telemann, G.P. 1725.Viola Concerto in G major https://youtu.be/yMpzPMkrALM?si=lpyDYITx63jTc6-K
BioMedical PortraitVI.c.9 HLH mutations obtain complex NKvs.CD8+ T cell alterations in cytototoxicity and proliferation.DJGPhD.21.11.23 Authentic Biochemistry. 22.11.2023 29:48
References Immunobiology. 2019 Jan; 224(1): 94–101 Front. Immunol., 14 June 2023 Cell. 2003 Nov 14;115(4):461-73 VonBingen. H. Born 1098AD https://youtu.be/yyAQc0kPZpU?si=y26mnCOmFpRis63_
BioMedical Portrait VI.c.8.The cytotoxicity of the NK cell Is a function of its bioenergetics. Glycolysis/OXPHOS vs. FAO/OXPHOS during activation/proliferation 21.11.2023 29:51
References Front Immunol. 2023; 14: 1151166. Inflammation Research :official journal of the European Histamine Research Society 2018.1420-908X, Vol. 67, Issue 10. J Cell Sci. 2011 Dec 15; 124(24): 4147–4159. Hunter, R. and J. Garcia 1970. "Sugaree" https://music.youtube.com/watch?v=sxF9UJ-Rm0E&si=S4F0LvlFvUsTE1OO
BioMedical PortraitVI.C.7 IEI/IEM pathobiochemistry involves bioenergetics, transcriptional , translational, and post-translational modification sequalae.DJGPhD.19.11.23 Authentic Biochemistry. 19.11.2023 30:00
References Front Immunol. 2022; 13: 950536. Inflamm Res. 2018 Oct;67(10):813-828 Mol Biol Rep. 2023; 50(8): 6963–6974. Front Immunol. 2023; 14: 1151166 Dr Guerra: Graduate biochemistry lecture archive Schubert. F . 1827.December. Impromptu #3 in G flat major performed by Khatia Buniatishvili https://youtu.be/LUp2u9wI1fY?si=hhiUmiyXyQ78Qtaw and "Questions" Manfred Mann 1976. https://youtu...
BioMedical Portrait VI c.6.Hemophagocytic lymphohistiocytosis ACAD9/Rab27A/+/- FBase1 mutations linked to NK and CTL immunodeficiences.DJGPhD. 16/11/23. Authentic Biochemistry. 17.11.2023 29:56
References Front Immunol. 2023; 14: 1151166. Int J Mol Sci. 2019 Jan; 20(2): 443.
BioMed Portrait VIc.5. NK cell Inborn Error Of Immunity links to failed fatty acyl CoA dehydrogenase-obtained immunodeficiency.DJGPhD. 15.11.23. Authentic Biochemistry 16.11.2023 30:00
References Front Immunol. 2023; 14: 1151166
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