Dr Daniel J. Guerra
Authentic Biochemistry
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Dr Daniel J. Guerra
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Último episódio
28 de out de 2026
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Episódios
BioMedical Portrait VI.c4. Tumor and DC antigen VAX directed melanoma therapy reveals CD8+CTL and NK cell surface population dynamics.DJGPhG.14.11.23. Authentic Biochemistry. 15.11.2023 30:00
References Cancers 2020, 12 (4),952 JBC. 2018. 293: 2422-2437. J Immunother Cancer. 2021 Nov;9(11):e003675 Front Oncol. 2023 May 18:13:1145667 Front. Immunol.2019. Sec. Cancer Immunity and Immunotherapy Volume 10 Int. J. Mol. Sci. 2019, 20(3), 646 Front Immunol. 2019; 10: 14 Vivaldi, A. 1716. RV589 Gloria https://youtu.be/2eWjQOdYzMQ?si=dpZaNZilqPXi6fJU
BioMedical PortraitVIc.3. NK cell phenotypic variation is tighly regulated to facillitate unique immune sequalae including tumor ablation, pathogen elimination and autoimmunity.13.11.23.DJGPhD 14.11.2023 30:00
References Immunity. 2018 Oct 16;49(4):695-708 Front Immunol. 2019; 10: 14 Front. Immunol., 24 July 2017 Vol 8. Sec. T Cell Biology
BioMedical ortrait VI. Development of a dendritic cell antigen presenting melanoma kinase derived vax targeting NK cells to ablate malignancy.DJGPhD.11NOV23 12.11.2023 30:00
References Front Immunol. 2019; 10: 14 Cancer Immunol Immunother. 2016 Apr;65(4):441-52 Anal Cell Pathol (Amst).2018; 2018: 787.1814. Molecular Cancer 2020. volume 19, Article number: 39 Cohan, G. 1917. "Over There" https://youtu.be/BYV044H5muI?si=LdANMG6dtXeC14tj
BioMedical Potrait VI. Natural Killer Cells: opening remarks. DJGPhD.9NOV23. Authentic Biochemistry 09.11.2023 29:42
References Anal Cell Pathol (Amst).2018; 2018: 787.1814 Zeno (the Eleatic) 5thCentury B.C. Magna Graecia, Italian Penn. Student of Parmenides Guerra-basic immunology lectures Schubert,F. 1826. String Quartet No. 15 in G major , D. 887. https://youtu.be/xW8PI2Xa8eA?si=smnLmSKamUP34qon
BioMedical Portrait V. Coda c.13 Small molecule pyrazolo-oxazepine derivitive mediated PFK-1 activation depletes NADPH dependent neutrophil oxidative burst. DJGPhD.07NOV23. Authentic Biochemistry 08.11.2023 30:00
References Cell 2021. 184, 1–15 J Zhejiang Univ Sci B. 2022 Jul 15; 23(7): 607–612.
BioMedical Portrait V.c.12. Is there a compositional-sequential event ontology linking "moonlighting"c-Fos with NOX2 PX domain PIP3 binding?DJGPhD. 6NOV23 06.11.2023 30:00
References Nature Communications 2019. volume 10, Article number: 1528 Adv Exp Med Biol. 2019:1111:1-17. doi10.1007/5584_2018_185. Nature Immunology volume 20, pages559–570 (2019) Biochem J. 2001 Dec 15; 360(Pt 3): 513–530. PNAS 1993. 90: 10952-10956
BioMedical Portrait V.c.11 The Phosphoglycerolipid metabolome that orchestrates membrane topology and surface chemistry that supports necessary protein association for neutrophil immunoresponses. 05.11.2023 30:00
References Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids2014.Volume 1841, Issue 9, Pages 1241-1246 Guerra-graduate lipid lectures
BioMedical Portrait V.c.10. Phosphphatidyl inositols and phagosmal genesis in activated neutrophils upon pathogen infection. 05.11.2023 29:54
References J Adv Res. 2018 May; 11: 33–41. Immunol Rev. 2023. Volume314, Issue1 . Special Issue: Neutrophils and Friends .March 2023. Pages 158-180. Biochim Biophys Acta Biomembr.. 2023 Oct;1865(7):184180 Front Cell Dev Biol. 2022; 10: 945749. Tchaikovsky, PI., 1878. Violin Concerto in D major, Opus 35 ( TH 59 ; ČW 54). https://youtu.be/2ckqOukGKK8?si=jl9TYFA2pgvtI8um
BioMedical PortraitV.c9. Both glycolytic and OPP regulation combine complex allosteric and amphibolic sequalae that may converge on an immune- hyperinflammatory state. DJGPhD.2NOV23. 02.11.2023 29:42
References Guerra 2023-graduate biochemistry lecture canon and marginalia Mol Oral Microbiol. 2019 Apr; 34(2): 27–38. Front Cell Dev Biol. 2022; 10: 945749. Mozart, WA. 1784. Piano Concerto No. 17 in G major, KV. 453 https://youtu.be/iYNbMclI5Ls?si=_P9oK14c_wb98VXG
BioMedical Portrait V.c8. NOX2 subunitorganization, oxygen availability and phase I discussion of glycolytic allosteric control.DJGPhD.01Nov23 01.11.2023 30:00
References FASEB 2017. Volume 31, Issue2 Pages 663-673 Guerra,DJ. Graduate Biochemistry Lectures Albioni , Thomaseo. 1708. Sonate da chiesa ("op. 4") (for violin and basso continuo), https://youtu.be/IMmjjcfG2c4?si=C4VG-rPWL_Fv7-Xe
BioMedical Portrait V C.5 Periodontitis-linked CVD. DJGPhD. 30.10.31 01.11.2023 30:00
References Eur J Microbiol Immunol (Bp). 2011 Mar;1(1): 41–58 J Periodontal Res. 2018 Jun; 53(3):403–413. DJGPhD lecture notes
BioMedical Portrait V. c7. NETs and the combined activities of elastase,NOX2,MPO and IP3 PTEN phosphatase potentiate inflammation-linked pathologies of lung and pancreas. DJGPhD.31.10.23 and 01.11.2023 29:59
References J Zhejiang Univ Sci B. 2022 Jul 15; 23(7): 607–612 Biomaterials. 2020 Apr; 238: 119836. Int J Nanomedicine . 2023;18:5265-5287 Child Ballad 100. 1775. Pentangle. 1972.Willie O' Winsbury https://youtu.be/nwqP_yoszCE?si=C0NH51euOOTlPYn9
BioMedical Portrait V C.6 P. gingivalis Two Component System assembly and activation mediate infection court involvement in subsequent host vector pathology.DJGPhD. 30.10.23b. 30.10.2023 30:00
References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2):S135–S139. J Oral Microbiol. 2017; 9(1): 1400858
BioMedical Portrait Vc4 Two component signal system pathogenic bacterial responses to host immunity and the gigipain cysteine protease opposing serum secretory IgA mediated phagocyte activation.DJGPhD 29.10.2023 30:00
References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2): S135–S139. J Oral Microbiol. 2017; 9(1): 1400858. J Dent Res. 2020 Jun;99(6):644-649. Mozart WA 1782. D major, K. 385. Symphony 35 (Haffner)
BioMedical Portrait V.c3. The categorical analysis of Neutrophil involvement in multiple pathophysiologies requires cellular signaling to derivatize pleiotropic disease ontologies. DJGPhD.26.10.23 27.10.2023 29:50
References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Gut Microbes. 2022; 14(1): 2073785. Adv Exp Med Biol. 2020:1263:13-23 Bredon, Anne. 1950. Led Zepplin. 1969. https://youtu.be/dZitPJMh60A?si=MnEpM-iemNFWEKE7
BioMedical Portrait V. The neutrohil oxidative burst and the roles of Phox generating superoxide and peptide arginine deiminase in phagocyte defense against pathogens and contrarion disease promotion. 26.10.2023 30:00
References Blood (2004) 103 (11): 3993–3994 Anticancer Agents Med Chem. 2023;23(3):256-265 Med Hypotheses. 2021 Jan:146:110466.
BioMedical Portrait V. Introductory alethic unfolding of neutrophil glycolysis associated hyperinflammatory restraint. 24.10.2023 29:56
References Cell. 2021 Aug 19;184(17):4480-4494.e15 Sci Rep. 2019 Mar 5;9(1):3433 Med Hypotheses. 2021 Jan:146:110466. Hayward, J. 1967. Moody Blues. "Tuesday Afternoon" https://youtu.be/jmMPBQ4kYKk?si=X0UyZJFq2AAnKSvJ
Continuing dialectical event ontology of epistemological requirements for validation of biochemical research. DJGPhD.23.10.23. Authentic Biochemistry Podcast 23.10.2023 29:59
Send an email to authenticbiochemistry@gmail.com with comments.
All reciprocity in not disinterested so phenomena must be in equilibrium. But phenomena at equilibrium are invisible so reciprocity must be uncertain. DJGPhD.22.10.23. Authentic Biochemistry 23.10.2023 29:59
Vide supra.
BioMedical Portrait IV. Postcript DJGPhD. 21 October 2023. Authentic Biochemistry Podcast 22.10.2023 30:00
References Cureus. 2022. 14(9): e29696.doi:10.7759/cureus.29696 NMR Biomed. 2021 Feb;34(2):e4448. NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Nutrients. 2023 May; 15(9): 2029. Mozart, WA. 1791 K 626 Requiem in d minor.
BioMedical Portrait IV. 13b. Magnetic Resonance Imaging as a non-invasive tool in Neurodegenerative Diseases. DJGPhD.19.10.23 Authentic Biochemistry. 19.10.2023 30:00
References Mol Cell Neurosci. 2012 Jan; 49(1): 44–53 NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5092–5094.
BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast 18.10.2023 30:00
References Brain. 2023 Sep 13:awad309. doi: 10.1093/brain/awad309 J Alzheimers Dis. 2016 Feb 26;52(1):43-50. Haydn, FJ. 1796. MISSA IN TEMPORE BELLI https://youtu.be/8_5tgmAwN-E?si=AYzyMMk47b2IUt0Y Send an email to Dr Guerra! authenticbiochemistry@gmail.com
BioMedica; Portrait IV Coda II.c12. Biochemical Concatenations-the spatiotemporal sequences of molecular-cellular events of FTD's from proteinopathies to signalling and antigen recognition. DJGPhD. 17.10.2023 29:55
References Brain. 2023 Sep 13:awad309 McBroom, Amanda. 1970 "the Rose" httBps://youtu.be/cO59ITNCxzk?si=v-qx_2_mPq3zbCYH
BioMedical Portrait IV c11. FTLD-tau is correlated with microglial and astrocytic inflammation and subsequent neural degeneration. DJGPhD. 16.10.23 Authentic Biochemistry. 17.10.2023 30:00
References Front. Immunol., 19 October 2022 Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309
BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast 16.10.2023 30:00
References Schubert, F. 1820. Rosamunde Overture. https://youtu.be/3Pc_LUItWQI?si=ZB3bsrmz3ReiJQdi Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309.
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