Dr Daniel J. Guerra
Authentic Biochemistry
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Dr Daniel J. Guerra
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27 de out de 2026
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Episódios
BioMedical Portrait VIII. c.21 Lysopholpids like sphingolipids hydrogen bond to cholesterol mediating lipid membrane raft mobility. DJGPhD. 2Feb2024. Authentic Biochemistry Podcast 03.02.2024 29:13
References Biochimica et Biophysica Acta (BBA) - Biomembranes 2015. Volume 1848, Issue 3 , Pages 805-812 Soft Matter 21-Jan-2021 Am J Rhinol Allergy. 2015 Jan-Feb; 29(1): 35–40. Scientific Reports 2017. volume 7 , Article number: 39661. Antioxid Redox Signal. 2011 Aug 15;15(4): 1043–1083. Journal of Immunotoxicology. 2008. 5:4, 347-352 Mozart, W. A. 1773, October. Symphony No. 25 in G minor K.183....
BioMedical Portrait VIII C.20. Heterologous lipid sequence membrane domains rearrange according to LysoPL polarity after PLA2 mediated 20:4 removal and acetosalicylic acid alters fatty acid ordering. 01.02.2024 30:00
References Soft Matter , 2021, 17 , 2742-2752 BBA Biomembranes 2015 Volume 1848, Issue 3 , Pages 805-812 Mozart, WA. 1788. Divertimento in E Major. K 563. https://youtu.be/E8c83bpOVXo?si=AUrRoRH0C1ie2xd0
BioMed PortraitVIII.c.19. Membrane thermotropic phase transition enthalpic responses to Leukotriene synthesis in relation to cholesterol and lysophospholipid fluid dynamics.DJGPhD.31.1.24.Authentic BC 31.01.2024 29:48
References Dr Guerra: membrane lectures Balin, M.1966. "Coming Back to Me" Jefferson Airplane. Surrealistic Pillow.1967. https://youtu.be/y2f3tlgApHw?si=cTa1nhYw6kcycxUs Dylan (Zimmerman),R. 1962 "Girl from the North Country". w. Johnny Cash. https://youtu.be/Je4Eg77YSSA?si=eYXfJhwOQisGjPHW Schubert, F. 1828.Piano Sonata in B-flat major, D.960 https://youtu.be/lncNcNtGkJY?si=KR...
BioMed Portrait VIII.c.18Aspirin PGS (COX) inhibited membrane topological and integrated molecular dynamics: leukotriene –cytokine mediated asthmatic inflammation.DJGPhD.29.1.24. Authentic Biochem. 29.01.2024 29:51
References Biochimica et Biophysica Acta (BBA) - Biomembranes 2015. Volume 1848, Issue 3 . Pages 805-812. J Immunol. 2018 Feb 1; 200(3): 915–927. Am J Rhinol Allergy. 2015 Jan-Feb; 29(1): 35–40. Corelli,A. 1714. Concerto in D Major Op. 6 No. 4, https://youtu.be/3smZkpqXYHs?si=uwEdDkRv-bz-zJXW
Sententia non Fengo, concluding remarks. BioMedical PortraitVIII. (C.17). LTC4 and LTD4 interact with IL-33 inducing cytokine generation in lung ILC2s.DJGPhD.28.1.24 29.01.2024 29:57
References J Immunol. 2018 Feb 1; 200(3): 915–927 Fontana, GB. 1641 Violin Sonata 2. https://youtu.be/2kkpqJkYmms?si=w-JT4cbsn9hl7GSP
Sententia non Fengo: A minor prolegomenon to the purpose of Authentic Biochemistry. DJGPhD.28.1.24 28.01.2024 29:59
References Plotinus. 204-270. ""Neoplatonist philosophy:The Enneads Kant, I. 1790. Critique of Judgment. Beatles. 1969. Abbey Road. https://youtu.be/oolpPmuK2I8?si=BKTiNJmp-omJ8lJH Aleotti, V. 1575-1620. Audivi vocem de caelo https://youtu.be/CaTNXjzQANs?si=Zh3whogggigHmp4i
BioMed Portrait VIII. c.16. Coordinated complimentarity of cell cycle MEK kinase cascade with the IL33-ST2 and CysLT1R mediatedILC2 activation to promote type 2 immunopathology. DJGPhD.25.1.24 26.01.2024 30:00
References J Immunol. 2018 Feb 1; 200(3): 915–927 Cells. 2020 Jan; 9(1): 198. Cells. 2022 Apr; 11(7): 1105 Nature Comm. 2020. volume 11, Article number: 35 Schubert F. 1829. Fantasie in F minor. D940 https://youtu.be/UyjzqPPXDcw?si=XW_SMP7j-Kza8pmq Winwood, Capaldi and Wood. 1967 (Traffic). "Dear Mr Fantasy" https://youtu.be/dyMiUmrouZU?si=1ZSdXupm3WFBAxTz
BioMedical Portrait VIII.c.15. ILC associated hippocampal RNA-BP's exacerbate GLU neurotoxicity and regulate CysLT1R in lung ILC2's. DJGPhD. 23.1.24. 23.01.2024 29:58
References Nat Commun. 2022; 13: 4435. Nat Commun 2020; 11: 35 Hayward, J. 1971. "You Can Never Go Home" Moody Blues. https://youtu.be/mUhboF8d1x0?si=IX4iP_W0f3uR65qo Jagger, Richards, Oldham. 1964. "As Tears Go By". Marianne Faithful. https://youtu.be/S8EykQaZ8CU?si=X42TiNsveR7rwdHB
BioMedical Portrait VIII.c.14 The dialectical events between immune responses and leukotriene signaling are modulated by tissue-resident and circulating cell patterns via RNA binding proteins.DJGPhD. 22.01.2024 29:49
References Nat Commun. 2022; 13: 4435. Virchows Archiv: European Journal of Pathology, 2020. Vol. 476, Issue 2 Cell Death Differ. 2015 Apr; 22(5): 703–718 Pentangle.1971. Hunting Song. https://youtu.be/CwvpMGc_J-w?si=s6pS2agc5s1N0H2z Falconieri , Cima, Uccellini, Turini, Merula, et al. 1600-1650. Early Italian Baroque Ensemble. https://music.youtube.com/playlist?list=OLAK5uy_mQznM05seareQTK-s3j-1V...
BioMedical PortraitVIII.c.13 Leukotriene metabolism and reception is linked to innate like lymphocytes involved in airway inflammation and hyper-responsiveness-associated asthma.DJGPhD.19.1.24.AB. 20.01.2024 29:40
References J Immunol. 2009 Feb 1; 182(3): 1641–1647. Cell Reports 2015 10, 2043-2054DOI Virchows Archiv:European Journal of Pathology. 2020. 09456317, Vol. 476, Issue 2 Poe, EA. 1845. "the Raven" https://youtu.be/wAdQ3CcPHQU?si=2qpStYF2gdUJ4f35 Buddy Morrow and his Orchestra. 1960. "the Black Cat" https://youtu.be/9w_VL7oq-mE?si=XiorgTkvSGzJ4BK0
BioMedical Portrait VIII.c.12. 5-LOX associates with FLAP and PLA2 at the nuclear envelope to trigger and control ILC2 mediation of the allergic asthma AHR pathology. DJGPhD 17.1.24. Authentic Bioch. 18.01.2024 30:00
References Immunology. 2019 Apr; 156(4): 402–412. J Immunol. 2017 Aug 1; 199(3): 1096–1104 Front. Immunol., 06 June 2019 Mol Biol Cell. 2012 Nov 15; 23(22):4456–4464. Virchows Archiv: European Journal of Pathology, 09456317, Feb2020, Vol. 476, Issue 2 Pavana, Gagliarda, Ciaccona, Passacaglia 1535-1615. https://youtu.be/AY533zpCw74?si=224HuGs438aPHrrd
BioMedical Portrait VIII. C.11 Peptidyl leukotrieneR- mediated transcription of PTGS2and LOX15B with IL4/IL13 and IL33 in asthmatic lung airway constrictionin MDM's LM's and ILC2's DJGPhD.16.1.24 17.01.2024 29:35
References Immunol.2017 Aug 1; 199(3): 1096–1104. British J of Pharmacology. 2015. Volume172, Issue17: 4319-4330 Beethoven, L. 1826. String Quartet Op. 135 in F Major (#16) https://youtu.be/1hxpIQ3XhXA?si=65eTt7TlOZYCNsG8
BioMedical Portrait VIII. c.10. The LOX5 and LOX12/15 pathways for 20:4, 20:5 and 22:6produce over 50 unique molecular species of oxylipins and lipoxins with unique biological sequalae.DJGPhD.14.1.24. 15.01.2024 29:40
References Int. J. Mol. Sci. 2022, 23(23), 14883. Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726. British J of Pharmacology. 2015. Volume172, Issue17. 4319-4330 Mozart, WA. 1791. Requiem. D Minor, K. 626 https://music.youtube.com/watch?v=RDegrbjfiWU&si=x-SSYDxEOv5Vc4xE Miller, S. 1977. Wintertime. https://youtu.be/HUv7pXgZ9NA?si=JzaZOWKLkPEMiyKj
BioMedical Portrait VIII. c.9. Initial detail of the LOX vs.COX isoform utilization of essential and other dietary PUFA's in complex leukotriene biosynthesis. DJGPhD.11Jan24.Authentic Biochemistry. 12.01.2024 30:00
References British J of Pharmacology 2015. Volume172, Issue17September Pages 4319-4330 Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726. 1718. Concerto No. 4 in F minor , Op. 8, RV 297, "Winter" ( L'inverno )
BioMedical Portrait vIII. Leukotrienes. c.8 Leukotriene regulated Heterodimer Nuclear Receptor transcription factors organize around complex multi-ligand binding and sojourner molecular modifiers 10.01.2024 28:54
References British J of Pharmacology 2015. Volume172, Issue17 September Pages 4319-4330 Chem Rev. 2011 Oct 12; 111(10): 6321–6340 JBiol Chem. 2020 Jul 17; 295(29): 10045–10061 Mozart, WA. 1768. January. Symphony #7 in D major K.45.composed in Vienna just 10 days before he turned 12 years old. https://youtu.be/ABOle_eSq9c?si=GcA8EvXbpEZP0W0A
BioMedical Portrait VIII.c.7. Differential control over fatty acid oxygenation and PPAR/RXR heterodimer pairing in mammalian uterine cell estrus physiology.DJGPhD.8Jan2024 09.01.2024 30:00
References General and Comparative Endocrinology,2018-06-01, Volume 262, Pages 27-35 Pisendel JG 1735.Violin Concerto in D major, JunP I.5. https://youtu.be/dvwhXXvFiNg?si=YfS2waKLC5WHy0En
EtOH Membrane Intoxication c.3. Epiphantei: ethanol-induced membrane degeneration results in altered porosity/tortuosity dynamics and microglia-failed tissue surveilance/repair in the CNS.DJGPhD. 06.01.2024 30:00
References Brain Imaging Behav. 2011 Sep; 5(3): 189–202 PLoS One. 2019; 14(1): e0210888. Alcohol, 2017-12-01, Volume 65, Pages 51-62 Clapton, E. and Martin Sharp .1967 "Tales of Brave Ulysses" https://youtu.be/I32Wwfv8v1U?si=TfUX6Xldenp_f5M5
EtOH c.2 Mean diffusivity and tortuosity metrics in ethanol induced white matter lesions. 06.01.2024 30:00
References PLoS One. 2019; 14(1): e0210888 Trends Neurosci. 2015 Jun; 38(6): 364–374 Addict Biol. 2006 Sep; 11(3-4): 339–355 Sci Rep. 2022; 12: 19463. Beethoven, L. 1809. Piano Concerto #5 in E-flat major, Op. 73, " Emperor Concerto " https://youtu.be/kiW-QnQzN9Y?si=qT6PgbhB9L5jpzcZ
BioMedical Portrait VIII.c.6 Precursor 20:4 5,8,11,14 derived prostaglandins and leukotriene roles in PPAR and RXR transcription factor expression in mammalian reproductive tissues. DJGPhD. 04JAN24.AB 04.01.2024 30:00
References General and Comparative Endocrinology 2018-06-01, Volume 262, Pages 27-35. Immunohorizons. 2022 Jun 22; 6(6): 366–372. Biochem J. 2009 Dec 14;425(1):265-74. Nature. 2023; 614(7948): 530–538. Winwood,S. 1969 Blind Faith "Had to Cry Today". https://youtu.be/Z4Yo_VbGdMg?si=3whbMcoWNFtfgPwE
Post Holiday EtOH Lectures. Volume One. Dr. Daniel J. Guerra. 01Jan2024. Authentic Biochemistry 02.01.2024 27:56
References Sci Adv. 2020 Jun; 6(26): eaba0154 Brahms , J. 1869 Schicksalslied ∙ hr-Sinfonieorchester. https://youtu.be/yC8CNpFu_7Q?si=ZqE0nuvXjaRJVcMh
BioMedical Portrait VIII.c.5 Leukotrienes. Lipoxygenase isoform mediated control over resident tissue macrophage speciation.Dr Daniel J. Guerra. 01Jan2024. Authentic Biochemistry Podcast 01.01.2024 29:58
References Immunohorizons. 2022 Jun 22; 6(6):366–372. Biochem J. 2009 Dec 14;425(1):265-74 Chem Rev. 2011 Oct 12; 111(10): 6321–6340. Telemann, Georg Philipp. 1699.Trauer-Actus, Cantus Cölln, Junghänel https://youtu.be/0yS7YIcwBq0?si=UaVMZzBtZc27t5Xp
BioMedical Portrait VIII. c.4 A deft-handed apprehension of chirality to facillitate reasoned appreciation of leukotriene molecular heterogeneity.DJGPhD. 30.12.23. Authentic Biochemistry. 31.12.2023 29:32
References Dr Guerra-notes Schubert. F. 1815 (late March-Early April. Stringt Quartet No. 9 in G minor (D.173) https://youtu.be/piIet7QVLGA?si=FcY0VUUXRPPekKs1
BioMedical Portrait VIII.c.3. Leukotriene molecular speciation involves subcellular re-distribution of modifying enzymes and adaptor proteins associating with ER and Nuclear membranes.DJGPhD.28.12.23 29.12.2023 29:59
References Infect Immun. 2021 Aug; 89(8): e00095-21. Eur J Immunol. 1992 Oct;22(10):2705-11 Progress in Lipid Researc 2015. h Volume 57 , January Pages 13-39 Am J Physiol. 1999 Apr;276(4):C988-94. Beethoven, L. 1813, 08 December.: Symphony no. 7 in A major, op. 92. https://youtu.be/T7CjuvE8oFA?si=il248jF2v7njd-Jo
BioMedical Portrait VIII.c.2 Leukotrienes: regio-associated oxygenation patterns of lipoxins and peptido-LTC's distrubute among pro-inflammatory states . DJGPhD. 27.12.23. Authentic Biochemistry 28.12.2023 29:51
References Am J Physiol . 1999 Apr;276(4):C988-94. Acta Derm Venereol 2017; 97: 922–927 Signal Transduction and Targeted Therapy 2021. volume 6 ,Article number: 94 J Adv Res. 2018 May; 11: 33–41. Progress in Lipid Research 2015. Volume 57 , January:13-39
BioMedical Portrait VIII. c.1 Leukotrienes: an Introduction. Dr Daniel J. Guerra. 26.12.23 Authentic Biochemistry Podcast. 27.12.2023 29:58
References J Periodontol, 2007. August 1. 78(8): 1620-6. Annu. Rev. Pharmacol. Toxicol. 2023. 63:407–28 Acta Derm Venereol. 2017; 97: 922–927 Moody Blues 1967.Nov10. Days of Future Passed. https://youtu.be/uZCzH8q1hcY?si=2cWl06wuBC4itE1k
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