Dr Daniel J. Guerra
Authentic Biochemistry
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Dr Daniel J. Guerra
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27 de out de 2026
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Episódios
Biochemical Mosaic II.c.8 Cell death and CE-circ RNA vs.miRNA in Hepatocellular carcinoma: the spectre of AGPS et al. DJGPhD. 10March24.Authentic Biochemistry. 11.03.2024 29:49
References Cell Death Dis. 2020 Dec; 11(12): 1065. Genome Res. 2000 Oct; 10(10): 1445–1452. https://www.genecards.org/cgi-bin/carddisp.pl?gene=NIPBL Genes Dis. 2022 Jan; 9(1): 116–127 Schubert, F. 1824. Quartet 14 in D minor , D 810, "Death and the Maiden" https://youtu.be/XF_6vSlmm4w?si=CGTn3R6Tkn6LsMLv Browne,J. 1993. "Sky Blue and Black". https://youtu.be/Ty1I6dtC2zc?si=QHu...
Biochemical Mosaic II.c.7. Fatty acid desaturation and mole% PC/PE/PL/CER are elevated via circRNA in Medublastoma while AGPS increased circRNA's in thyroid cancer.DJGPhD.7Mar24. Authentic Biochem. 08.03.2024 29:49
References Acta Neuropathologica Communications 2023. volume 11, Article number: 38 Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7792–7798 Front Mol Biosci. 2022; 9: 925389. Front Cell Dev Biol. 2021; 9: 636838 Oncol Lett 2018. 15: 7889-7899. Saint-Saëns, C. 1886. Symphony No 3 in C minor, Op 78 https://youtu.be/ZWCZq33BrOo?si=8hQ01E9jfp0eU07o Winwood,S. 1969. Had to Cry Today (Blind Faith) http...
Biochemical Mosaic II.c.6 Meduloblastoma is linked to plasmalogen and circ RNA phenomena that are pathophenocopied in other cancers. DJGPhD.5.Mar24.Authentic Biochemistry 06.03.2024 30:00
References Acta Neuropathologica Communications 2023. volume 11 , Article number: 38 Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7792–7798. Int J Med Sci. 2022; 19(6): 975–985 Nature Communications 2022. volume 13 , Article number: 1508 Lassus. O. 1578. Requiem - Missa pro defunctis (4vv) : Offertorium https://youtu.be/UXY4hxCvu7M?si=lcM_lw11lbPWrYX4
Biochemical Mosaic II. c.5 Peroxisomal plasmalogen biosynthesis may regulate transcriptomic and proteomic sequalae to plasmamembrane mediated signal transduction. DJGPhD.4March24. 04.03.2024 30:00
References Front Physiol. 2021; 12: 730829. Non-coding RNA Investig 2017. 1:5. Genome Biology 2011. volume 12 , Article number: 236 RNA Biol . 2021 Nov 12;18(sup2):574-585. Hunter. R. 1975. "Cruel White Water" https://youtu.be/T-oBD3F74Nk?si=zsrEBN0JKan_FXdH
Biochemical Mosaic II. c.4. Peroxisomal biogenesis and AGPS-mediated plasmalogen synthesis involve circular RNA species that alter microRNA and mRNA expression in human cancers. DJGPhD.3MAR24. 04.03.2024 29:48
References Genome Res. 2004 Nov;14(11): 2245–2252. Int J Med Sci. 2022; 19(6): 975–985. Oncol Lett. 2018 May; 15(5): 7889–7899. Cell Death Dis. 2020 Dec; 11(12): 1065. RNA Biol . 2021 Nov 12;18(sup2):574-585 Bach, J Christian. 1775. Sinfonie Concertante https://youtu.be/S8NPgouJ5uk?si=_azSWNelNFRA2ai5
Saturday Night Authentic Biochemistry The Agentic operator as metaphysical metaphor in metabolic regulation. DJGPhD.2March 2024. 03.03.2024 30:00
References Dr Guerra Archives: Graduate Biochemistry Lecture notes and syntheses Simon, P. 1969. The Boxer. https://youtu.be/l3LFML_pxlY?si=Nv5-mSzRu6fHP8Sr Boccherini, L. 1760. 7. Cellokonzert https://youtu.be/NSU6Ylxaobs?si=PZW0S3mWl25RwnE2
Biochemical Mosaic II. c.3 Plasmalogen metabolism is coherently associated with peroxisomal integrity and replication. DJGPhD.01March 2024 Authentic Biochemistry. 02.03.2024 30:00
References Oncol Lett. 2018 May; 15(5): 7889–7899 Nat Genet. 1997 Apr;15(4):369-76 Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118609 Protein Cell 2018. 9, 196–206 Brain Research Bulletin 2023. 194: 118–123 The Moody Blues. 1968. "In Search of the Lost Chord" https://youtu.be/k5UdP-SFNgY?si=zDboUgA2LDi3E7m1
Biochemical Mosaic II. C.2. Plasmalogen and PAF biosynthesis in relation to glycerol lipid and intermediary subcellular metabolism.DJGPhD.27.2.24 28.02.2024 29:59
References Guerra: graduate biochemistry lectures Chopin, F. 1830. Nocturne E Flat Major Op.9 No.2 https://youtu.be/tV5U8kVYS88?si=MKxfguVRI6hhQeMO Winwood, Wood and Capaldi 1967. Dear Mr Fantasy. Traffic. https://youtu.be/sS_eHdqcrM8?si=95X9RWJD2Q4w456S
Biochemical Mosaic II. Plasmalogens & other ether lipids. c.1 DJGPhD.26.2.24. Authentic Biochemistry Podcast 26.02.2024 29:36
References Cell Metab. 2014 Mar 4; 19(3): 380–392. Protein Cell 2018. 9 , 196–206. Membranes 2023 , 13 (9), 764. Debussy , C. (. 1890;1905) Clair de lune. https://youtu.be/6zzWnxuQPWI?si=gcEAKpbgc9xO8esf Morricone. E. 1968. "Once Upon a Time in the West" https://youtu.be/j5eQ9UTmDLo?si=-eUjJ1s9hAd6fpwz Schubert, F. 1825. Ave Maria https://youtu.be/2H5rusicEnc?si=LcYisCODwtGgjjVx
A Dialectical Interlocution with Mozart. DJGPhD.24.2.24 Authentic Biochemistry Podcast 25.02.2024 28:52
References Mozart. WA 1782. Fantasie in D minor. K.397 https://youtu.be/OYiz_u0tDwM?si=0dP736rTEkb4sauL 1785.Piano Concerto 22 in E flat Major. K.482 https://youtu.be/EJYPnrYNt8A?si=VqgS-PNw2bnbIFBj 1788. Divertimento in E♭ major , K. 563. https://youtu.be/2N4hHhTu4pw?si=p-VwHTTOK5ixFWfk 1787. Eine kleine Nachtmusik, K. 525. https://youtu.be/156u4nV2uGE?si=bRqysFpbi-6j0jMk
Biochemical Mosaic I. CODA. Membrane lipids function as biosensors for pKa's of phosphonoester anionic charge density with polybasic protein domains to mediate communication including transcription. 24.02.2024 29:53
References J Biol Chem 2017 292: 20481. Nature Cell Biology 2019. volume 21 , pages 338–347 Rossini. G. 1829. William Tell Overture. https://youtu.be/z7Tj2SzToHI?si=QUXkj3NzqF17Zq60 Vivaldi, A. 1712. Concerto in D Major. RV 212. https://youtu.be/l21_9KKy1Pg?si=9HSMxRj7huJF1B8j
Biochemical MosaicI.c.13 Phosphatidic acid as key lipid intermediary of membrane secretion signalling and cellular intracommunication via kinase cascade and transcriptional regulation.DJGPhD.22.2.24 23.02.2024 29:55
References Biomedicines 2023, 11(7), 1804 BMC Biology. 2011. 9:85 Cancer Res. 2011 Jan 15;71(2):293-7. FEBS Lett .2019.593.17 : 2428-2451 Verdi, G. 1841. Nabucco Overture https://youtu.be/OseGETWEnCo?si=LhiIQV-N0-_Z_s-s Lennon&McCartney. 1966 "For No One". Beatles: Revolver. https://youtu.be/sep5E3ssXLQ?si=WLtMrP-Xq279qZXl
Biochemical Mosaic I. c.12. The porosomal secretory system requires anioic lipids including phosphatidic acid. DJGPhD.21.2.24 22.02.2024 29:33
Dr. Guerra: membrane graduate biochemistry lecture notes J Cell Mol Med . 2015 Jul;19(7):1427-40 Langmuir, 2018, 34 (1), pp 530–539 Elgar, E. 1900. The Dream of Gerontius https://youtu.be/rnwmVypRY-g?si=CxF8tZrfRR-uWdhn
Biochemical Mosaic I.c.11. Glycerolipid metabolism coupled to mTORC1 enzyme phosphorylation necessarily involves a complete analysis of membrane lipid molecular species distribution.DJGPhD.20.2.24 20.02.2024 29:56
References Nature . 2019 Nov;575(7782):361-365. Adv Biol Regul. 2017 May:64:39-48 J Biol Chem. 2013 Apr 5; 288(14): 9933–9945 Redox Biology .2017. Volume 11 , April. Pages 622-630 Biochim Biophys Acta. 2011 Jun;1811(6):377-85 Dr Guerra: lipid lectures archives Schubert, F. 1816. Symphony #5 https://youtu.be/OHkot1TmvZU?si=uYtQfxUegl3KrkRK Newman, L Darby K. 1954. Marilyn Monroe. The River of No Re...
Biochemical Mosaic I c.10. Is PE depletion reversed by mTORC1 phosphorylation of LIPIN1 or is DAG authentically activating CCT via membrane association thus obtaining robust PL synthesis? DJGPhD. 19.02.2024 30:00
References Biochim Biophys Acta. 2011 Jun;1811(6):377-85 Am J Physiol Lung Cell Mol Physiol 2001. 281: L98–L107. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1997. Volume 1348, Issues 1–2 , 4 Pages 79-90. Am J Physiol Lung Cell Mol Physiol 2001. Volume 281. Issue 1 July Pages L108-L118 JBC 1991. Volume 266, Issue 36 , 25 December. Pages 24503-24508 Progress in Lipid Research....
Biochemical Mosaic I. c.9 Increased inner mitochondrial membrane PE from PS decarboxylase decreases protease mediated degradation of phospholipid transfer proteins thus maintaining fusion potency. 19.02.2024 30:00
References PLoS Biol 2014. 12(10): e1001969 J Biol Chem. 2012 May18;287(21):17589-17597 J Biol Chem. 2012 Nov 23;287(48):40131-9 Nature 2019. volume 575, pages 361–365 Alleluia: Lobet den Herren.
Biochemical Mosaic I PA-phosphatase c.8. Membrane fusion and the dynamics of mitochondrial reduction vs. proliferation; the PA phosphatase in lipid metabolism. DJGPhD. 16.2.24 Authentic Biochemistry 17.02.2024 29:48
References Dr Guerra membrane lectures archive FASEB J. 2021 Jun; 35(6): e21620. Vivaldi, A. 1711. Concerto for 4 Violins in B minor RV 580 https://youtu.be/SY3Kxf7ZTeI?si=JLQXMtK06Y6Yfu_k
Biochemical Mosaic I. Phosphatidic acid Phosphatase. c.7. Mutational reversal of IDH1 leads to NADPH depletion concomitant with potent anti-PHD enantiomeric 2-hydroxyglutarate obtaining pseudohypoxia. 16.02.2024 30:00
References FEMS Microbiol Rev.1998. Oct;22(4):255-75 Discoveries(Craiova). 2017 Jul-Sep; 5(3): e77. J Cell Mol Med. 2015 Jul; 19(7): 1427–1440. Oncogene. 2017 Mar 23; 36(12): 1607–1618. Bach, JS. 1742. Kunst der Fuge , BWV 1080; Marta Czech https://youtu.be/p1Sq1HOYglU?si=2GMF7kf3dLW4rr2O Lennon and MCartney.1968. "Martha my Dear" https://youtu.be/RXawa90YU2s?si=dUPDtTdm4UqrgWit
Biochemical Mosaic I. The PA phosphatase c.6. Alteration of the TCA pathway intermediates and hypoxia/nutrient deficiency control HIF1α stability indirectly regulating IMM protein and lipid turnover. 13.02.2024 30:00
References Front. Oncol. 2017. 26 November. V.7. Oncogene. 2017 Mar 23; 36(12): 1607–1618. Schubert, F. 1819 Piano Quintet in A major, D. 667/ "Trout" https://youtu.be/syod5rkFdNY?si=5F3rexiou7dTifYg Hunter, R., Garcia , J. 1970 "Ripple" https://youtu.be/xofhZx9eWUQ?si=tpOAMzyW5qUy01P_
The Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.5. Tumor cells adapt bioenergetic fuel economy toward cell immortalization via re-crafting of mitochondrial IM lipid speciation.DJGPhD.12Feb24 12.02.2024 30:00
References Cell Metabolism 2019. 30: 720–734 Nature 2019. 575: 361–365 Squire, C. 1978. "Onward" Yes.
Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.4 GLN utilization and an IMM protease regulate mitochondrial involvement in cancer growth. DJGPhD. Authentic Biochemistry 10Feb24 11.02.2024 30:00
References Cell Death & Disease 2022. volume 13.Article number: 444. Nature 2019. volume 575, pages 361–365 Scientific Reports 2021. volume 11, Article number: 16512 Experimental & Molecular Medicine 2020. volume 52 , pages 1496–1516 Mozart, WA. 1788. Piano Trio in G Major, KV 564 https://youtu.be/oOEuVtr8sF0?si=3-9RK1XkGkSWne7I
Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. c.3 Indirect consequences of mitochondrial proteomic variation potentially obtains GLN-linked Warburg glycolysis preventing ROS. 09.02.2024 29:48
References Cell Metabolism 2019. 30, 720–734 Redox Biology2013. Volume 1, Issue 1: 427-432 Nature 2019. volume 575. 361–365 Mozart, WA, 1779.Sinfonia Concertante Es-Dur, KV 364 https://youtu.be/iGDfj5uM_qA?si=bKNmj1r1o9zSMaA7 Lennon-McCartney. 1966. "Im Only Sleeping" https://youtu.be/sAG3m3p9UeI?si=oT6Luxnc6eFS_pEq
Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Autophagy commitment is linked to mTORC1 v. AMPK oppostional kinase networks maintaining proteostasis and lipid homeostasis.DJGPhD 09.02.2024 30:00
References Nature 2019.volume 575, pages 361–365 Cells 2022, 11(21), 3339 Guerra: Polypeptide, endomembranous lipid homeostasis, and bioenergetics lecture archives.
Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Prologomena c.1. 07.02.2024 30:00
References J Cell Biol. 2014 Mar 17; 204(6):919–929 Nature 2019. Volume 575, pages 361–365. Redox Biology 2013. Volume 1, Issue 1. Pages 427-432. Madrigali Guerrieri et Amorosi {Libro Ottavo} https://youtu.be/2TjkhWARBVE?si=-ZI_kVa5WZX_9qnB
BioMedical Portrait VIII. C.22 CODA. Microglial Leukotrienes in neurodegeneration.DJGPhD.04Feb2024. Authentic Biochemistry Podcast. 04.02.2024 30:00
References Acta Neuropathologica Communications 2020. volume 8, Article number: 129. J Lipid Res. 2019 Feb; 60(2): 219–226. Palestrina, G. 1562. Missa papae Marcelli https://youtu.be/KSmT4VIjEtI?si=6s7MtdTuH0fsURU5
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