Dr Daniel J. Guerra
Authentic Biochemistry
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Dr Daniel J. Guerra
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27 de out de 2026
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T lymphocyte Membrane Biochemistry I. Immune Cell Biochemistry I c.5 Authentic Biochemistry 16April2024 Dr Daniel J. Guerra 17.04.2024 29:51
References Front. Immunol., 2022 Sec. Microbial Immunology Volume 12 Blood 2010. Volume 115, Issue 18 , 6 May: 3708-3717 Seeger, P. 1959 . Performed by The Byrds "Turn Turn Turn" https://youtu.be/W4ga_M5Zdn4?si=ODKk_snS-5XHZvWP Copland, A. 1944. "Appalachian Spring. https://youtu.be/CJYVH_kZkOk?si=UUBet58ETg0PVUrB
Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.4. 15April 2024. Chemokine gradients and the membrane lipid raft. Authentic Biochemistry Podcast Dr. Daniel J. Guerra 16.04.2024 29:58
References FEBS J. 2018 Aug; 285(16): 2944–2971. Nature Reviews Immunology 2023. volume 23 , pages 236–250. Angiogenesis. 2021; 24(4): 719–753. Front. Immunol. 2022 Sec. Microbial Immunology Volume 12 Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service. https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D
Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.3. 14 April 2024 .Authentic Biochemistry Podcast.Dr. Daniel J. Guerra 15.04.2024 29:57
References Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366 Drugs. 2016 Jul;76(11):1067-79. Front Immunol. 2021; 12: 613591 J Appl Microbiol. 2009. Jun;106(6):1908-18 Exp Cell Res. 2015 May 1; 333(2): 195–200. Mediators Inflamm. 2017; 2017: 4806541. Parsons, G. McQuinn,R. 1971. Pale Blue [ Byrds] Byrdmaniax lp. https://youtu.be/Mh3J7GqrdzY?si=Kp0XfrwPtSi4vY6q Baker, G. 1967. "Blue Condit...
Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.2 Lipid mespmorph and radius assymetry direct Tcell membrane sterol and protein interdigitation that is altered by pressure via PV=nRT. 13.04.2024 30:00
References and simple equations PV = nRT where P is pressure (in atm), V is volume (in liters), n is number of moles and T is temperature (in K); R is a constant and is equal to 0.08206 L atm/moleK. Molecular Shape including thickness(radius) of membrane curvature is v/al where v=volume,a=area per headgroup, and l=thickness of the hydrocarbon monolayer Guerra, D. Membrane Biochemistry notes
Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.1. DJGPhD.11April24.Authentic Biochemistry Podcast 12.04.2024 29:55
References Front Immunol . 2021 Mar 10:12:613591. Guerra, D. 2020's. Membrane Biochemistry Lectures Crosby, D., Kantner, P., and Stills, S. 1968. "Wooden Ships" [Jefferson Airplane ] from Volunteers lp. https://youtu.be/ROBaoiJK0wc?si=ABsxa4m4AjjAwoms Mendelsshon, F. 1830. "The Hebrides Overture"-Fingal's Cave. OP26. https://youtu.be/MdQyN7MYSN8?si=w9G1d0_5DFJn-tzx
Biochemical Mosaic III. Coda. DJGPhD .09April24.Authentic Biochemistry Podcast 10.04.2024 30:00
References Guerra, D. 2024. The Mosaics I-III. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Beethoven, LV. 1806. Violin Concerto D Major. Op 61. https://youtu.be/cokCgWPRZPg?si=pKKUsINChgI14PH9
Biochemical Mosaic III. c.14. From physical chemistry to the mechanisms of sphingomyelinase mediated inflammation: abrief dialectical accounting of research involving abiotic vs biological phenomena. 08.04.2024 30:00
References Guerra, D. 2024. Previous Lectures: Authentic Biochemistry. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Waters, R.1973. "Eclipse" from [Dark Side of the Moon]; Pink Floyd lp. https://youtu.be/k0xGxnZFNYs?si=VrfYPQuXef41Drfm Holst, G. 1918. "The Planets" https://youtu.be/HP5xhyPn58U?si=IdN_iqJNvt_tjQKP
Biochemical Mosaic III.c.13. A priori intralocution of inflammasome genomic loci with stress phenomena immunoepigenetically resolves defensive inflammation. DJGPhD.6April24. Authentic Biochemistry. 07.04.2024 30:00
References Guerra, D. 2024 Previous Mosaic III lectures and content. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Hayward, J. 1969. "Never Comes the Day" from Moody Blues lp. Threshold of a Dream. https://youtu.be/8u1zH11yqFQ?si=xtXp1SWm8rF1RdFS Mozart, WA.1785. String Quartet No. 19 in C Major , K. 465 https://youtu.be/f3oK4XVMARs?si=FMypvP8O_WCII7vR Page, J...
Biochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry Podcast 05.04.2024 29:57
Refernces Guerra, DJ. Inclusive non-extemporaneous reasoning on biochemical event ontologies. Jefferson, Blind Lemon 1927, Hunter-Garcia 1969 Jefferson's "I know You Rider" and "China Cat Sunflower" . Grateful Dead. Europe 72' LP. https://youtu.be/xCgZxrf8nrU?si=k7WGmY-fo_AjEip- Schmelzer, JH 1664. Violin Sonatas, "Romanesca". https://youtu.be/fB8G39y1uCA?si=h...
Biochemical Mosaic III. Inflamasomes c.11 A Dialectical Event Ontological conciliantus contrarion perspective.DJGPhD.3April24.Authentic Biochemistry Podcast. 04.04.2024 29:22
REferences Guerra, DJ. 2024. Biochemical Mosaic III lectures. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Dvorak, A. 1879. Romance in F minor, Op. 11, (B. 39). https://youtu.be/XZTeavJ9frA?si=18LFzAQ9FKfrQ_16 Dylan, R. 1975. "Tangled up in Blue" performed by Gerry Garcia Band (live;1977) https://youtu.be/8Aw7FW1Frjs?si=jURQC3jBWFPirSh8 Betts, R. 1972. "...
Biochemical Mosaic III.c.10 Atherogenesis and neointma formation are associated with sphingomyelinase membrane raft NOX aggregation during inflammasome activation.DJGPhD.2April24 03.04.2024 29:47
References J Lipid Res. 2022 Dec; 63(12): 100298. Mol Cells. 2020 Aug 31; 43(8): 749–762. Bach J.S. 1727. St Matthew Passion, BWV 244. https://www.youtube.com/live/3fP-rET0kFI?si=ZX-edMPg1wBA_5mh Squire, Chris. 1978. "You Can Be Saved" Yes. https://youtu.be/0TNzPHoVlz8?si=bFMp6w4T2SL6XxS4
Biochemical Mosaic III.c.9 Clinical associations of inflammasome mediated pathophysiology linked to epigenetic methylation patterning and DNA repair. DJGPhD.1April24. 02.04.2024 30:00
References Redox Biol. 2020 Apr; 31: 101482 Nat Rev Microbiol. 2009 Feb; 7(2): 99–109. J Neuroinflammation. 2019; 16: 236. Front Pharmacol. 2021; 12: 643254. Biber, H. 1676. "Passagalia" por solo violin https://youtu.be/sgcR183f8gA?si=ovfSbdg6WsfuIiTw McBroom, A. 1976. "The Rose" Conway Twitty https://youtu.be/cO59ITNCxzk?si=ueMmXtzMNH4YeQ_w Hunter-Weir. 1970. "Sugar Magno...
Biochemical Mosaic III.c.8. S. aureus clearance via dual pyroptosis and necroptosis salientsand the control over the hyperinflammatory axis of clinical disease. DJGPhD.31.3.24 01.04.2024 29:19
References Cell Reports 2016.Volume 16, Issue 8, 23 Pages 2219-2230 Front Immunol. 2020; 11: 621733 Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969
Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies 28.03.2024 30:00
References Int J Mol Sci. 2021 Jul; 22(14): 7580. Trends Biochem Sci. 2023 Apr;48(4):331-344 Immunology. 2020;159:142–155 Curr. Opin. Immunol. 2020;62:39–44. Nat. Rev. Mol. Cell Biol. 2019;20:569–570. Lennon-McCartney. 1963. "This Boy" https://youtu.be/lW5D7HpYhBU?si=mHyiFng3rd3pukob Lennon-McCartney.1966. "And your Bird Can Sing" https://youtu.be/sOUlbredoUM?si=nPB64c8GS4joYx9...
Biochemical Mosaic III. c.6. S auereus induced inflammasome activating pyroptosis circumvents immune clearance and ARDS pulmonary chronic activation share similar hyperinflammatory presentation.DJGPhD 27.03.2024 30:00
References Front Immunol. 2019; 10: 1309 Immunity. 2018 Sep 18; 49(3):413–426.e5. Front Immunol. 2020; 11: 621733 Infect Immun . 2013 Dec; 81(12): 4478–4489. Immunity. 2023 Nov 14;56(11):2523-2541.e8. Harrison, G. 1969. "Here Comes the Sun" Abbey Road Lp. Beatles https://youtu.be/GKdl-GCsNJ0?si=xUqwi3Q7Ne694ruD Mozart, WA. 1775. Violin Concerto No.3 in G major, K. 216 https://youtu.be/j7...
Biochemical Mosaic III. c.5. Gal3 and NRLP3 inflammasome coordinate inflammation via IL-1Beta convertase activation that is associated with NAFLD and NASH and inhibition of ABCA1 cholesterol efflux. 25.03.2024 29:20
References Infect Immun . 2013 Dec; 81(12): 4478–4489 Cell Cycle. 2022; 21(11): 1121–1139. The Journal of Nutritional Biochem.2023.Volume 112, 109217 Lightfoot, G. 1964. "Early Morning Rain" https://youtu.be/ZFJ5Bj_put0?si=m1Ue7rFfk_ggSLR3 Simon ,P. 1968. "Old Friends" SImon and Garfunkle Bookends LP. https://youtu.be/7A76lTte8qE?si=rfk3Q6wTA6Nsiok7 Mozart, WA. 1782 Serenade in...
Biochemical MosaicIII. C.4. My oppositional dialectic and episteme- metaphysical discourse on method+ Gal3 as proinflammatory lectin may not uniformly correlate with pathobiochemical events. DJGPhD. 23.03.2024 30:00
References Guerra, DJ. 2024. Uncollected writings. The Journal of Nutritional Biochemistry 2023. Volume 112, February. 109217 Walker, Cindy.1950 Blue Canadian Rockies. Cover "the Byrds"(1969). https://youtu.be/nzOHtU8Sb3c?si=5GAj7VPzIr7o0OO_t Heinichen J. D. 1711 (?)Concerto in A minor for violin https://youtu.be/V-E25Q-wjwc?si=bbWdZTNEUPGitY-S
Biochemical Mosaic III c.3. Bacterial glycosphingolipid mediated inflammasome activation and the Galectin:NLRP3 interaction pathophenocopy oxy-mtDNA TLR induction.DJGPhD.21.3.24 22.03.2024 28:50
References Front Immunol. 2020; 11: 591803 Am J Gastroenterol. 2004 Nov;99(11):2147-9. Biochem Biophys Res Commun. 2005 Dec 16;338(2):1031-6 Front Immunol. 2019 Jun 7;10:1309. FASEB J. 2021 May; 35(5): e21439. Hildegard von Bingen 1150.- "Canticles Of Ecstasy
Biochemical Mosaic III. C.2 A Non-canonical autophagic inhibition of NLRP3 inflammasome mediated inflammation in UVB-treated human keratinocytes.DJGPhD. 20.3.24. 21.03.2024 30:00
References Front Immunol. 2019 Jun 7;10:1309. JBC 2024 . March. Article in Press DOI:https://doi.org/10.1016/j.jbc.2024.107173 FASEB J. 2016 Dec;30(12):4202-4213. Nat Rev Gastroenterol Hepatol . 2020 Feb;17(2):93-110 Bach , JS. 1731. Piano Partita No. 2 In C Minor, BWV 826 https://youtu.be/f-OdOuNZciQ?si=AmFtC5CX3x2ndzdV Slade,Mann, and Rogers. 1975 "Time is Right" Manfred Mann https://y...
Biochemical Mosaic III. C.1. Inflammasomes. DJGPhD.19.3.24 Authentic Biochemistry Podcast 20.03.2024 30:00
References I mmunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8 JBC 2024. March. Article in Press https://doi.org/10.1016/j.jbc.2024.107173 Schmelzer. J. H.1664 Sonatae unarum fidium. https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR Hayward, J. 1967 "Tuesday Afternoon" Moody Blues https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR Hayward, J. 1970 "Question" Moody Blues https://...
Biochemical MosaicII.Book2.C.13.Dialectical event ontologies involving CNS plasmalogen and sphingolipid interlocution and the universality of Mozart and the Beatles. DJGPhD.17.3.24.Authentic Biochem. 18.03.2024 30:00
REferences Dr. Guerra. 2024.Previous Authentic Biochemistry Mosaic II lectures in the series Kant, I. 1790. Critique of Judgment. Mozart, WA. 1788. Sinfonie C-Dur KV 551 (»Jupiter«) https://youtu.be/6RbKWhr0o1c?si=xkt3QMG5aud__zLN Beatles. 1965. "Rubber Soul" https://youtu.be/kfSQkZuIx84?si=8QFvenLD4k8KLJD3
Biochemical Mosaic II.Book 2. c.12 Adduced mTORC mediated glycerol-sphingolipid enzyme mRNA transcriptome association with Plasmalogen apodiction of myelination.DJGPhD.16.3.24 17.03.2024 29:45
References Developmental Cell 2022. Volume 57, Issue 6 , 28 March Pages 691-706 Cell Rep. 2014 Feb 13; 6(3): 541–552. Dr Guerra: graduate lecture notes Mozart, WA 1791.Requiem in D Minor, K 626 https://youtu.be/YaH3zI0bYkM?si=X1yv50zY6nKTZmV9 Lennon/McCartney.1964 "I Don't Want to Spoil the Party" https://youtu.be/zqVDvLDLsjI?si=K1ve_5zJLZjqclsb
MosaicII,Bk.2.c.11 Squalene monooxygenase (SM) stabilization due to plasmalogen pathway fatty acid reductase deficiency promotes SM epoxidase alternate activity thus lowering24OHCHOL-LXR-myelination. 14.03.2024 29:52
References Dr Guerra-Graduate lipid biochemistry lectures Biochem J. 2022 Sep 30; 479(18): 1917–1940 Front Cell Dev Biol. 2022; 10: 946393. Nat Commun. 2019; 10: 97. Lennon-McCartney 1965. "Ive Just Seen a Face" https://youtu.be/m8LbJfC0SYM?si=gl_URu_yPTn9iZSd McShee, J./Traditional/Pentangle.1969 "Light Flight" https://youtu.be/2tyVezuUtCA?si=THxBJ0reUETkwDLa Mozart, WA. 1785....
Biochemical Mosaic II. Book2. c.10.Plasmalogen mediated oxy vs epoxy sterol synthesis may control cns inflammation and myelination given acid-catalyzed transacetalization sequalae.DJGPhD.12March24 13.03.2024 29:28
References Front Cell Dev Biol. 2022; 10: 946393. Adv Exp Med Biol. 2024:1440:149-161 Mozart, WA..1786.Horn Concerto in E-flat major # 4 KV 495 https://youtu.be/MMjqU461WpI?si=o2OWIijoe-mbF-pM Sebastian, J. 1968 She's a Lady https://youtu.be/xyFdzevDOHg?si=wgmv5z_jGrtA9x7c
Biochemical Mosaic II. Book2. c.9. Plasmalogen regulation of composite ruling over prescriptive organization of cellular-biochemical phenomena includes florid mediation of the CNS.DJGPhD.11MARCH2024. 12.03.2024 29:38
References Journal of Cell Science 2019.Vol.132(6), 223016. Brain Research Bulletin 2023. Volume 194 , March. Pages 118-123. Beethoven, LV. 1806. Violin Concerto D major , Op. 61 https://youtu.be/_hXdjRYELGw?si=0q5_qJCZu_zAZWoE Berry, C. 1956. "Roll Over Beethoven" ; as performed by the Beatles 1963 on LP "With the Beatles" https://youtu.be/Hz5jXwOXgKQ?si=FASk6PG2SAsEkrvP
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