X-Health.show - meet the future of healthcare

He dropped his engineering job to run 5 Ironman triathlons in 5 countries for a cause. But he did not foresee he would gather so many scientists on the way that try to find a way to mitigate dementia You’ll hear what does it take to run an Ironman triathlon how his family coped with his father’s Alzheimer’s how he united several startups and researchers to launch a study on the impact of lifestyle...

Can the Dark Genome have the answer to any disease? And if you are wondering, what is the dark genome, you are not alone. And it is absolutely fascinating. Some scientists believe that the dark matter of the genome – previously called junk genome – might have the answer to many, many diseases. With the potential to cure them completely. Today we are speaking about heart fibrosis and also: the rich...

Haven’t heard about breathing rate tracking yet? Listen up. You won’t need much to improve running: just your headset and an app. In this episode, you’ll hear about training plans based on breathing teaching ML models to recognize breathing patterns huge breathing data sets and how will you be able to use them to improve running and your training efficiency Dr. Patrick Helfenstein is the co-founde...

Challenging an over 100-year-old histology technic that is prone to false negatives. In cancer diagnostics. My guest aims to take histopathology departments from the 20th century into the 21st century, where they belong. From slicing biopsy samples into 3D. From a manual preparation to a robotic one. Where all abnormalities will be pointed out and counted by AI. And human physicians will see insid...

Another silent killer on the X-Health.show: diabetic neuropathy. Undetected in too many instances. Slowly taking away the balance. Implementing pain. Starting at the feet and unstoppable, if not treated. In this episode, you’ll hear about diabetic neuropathy and diabetic neuropathic pain the millions of people it concerns why the current treatment is simply not enough what change wearing a smart s...

How one approaches the goal of replacing chemotherapy with a gentler process? Where does the “we can do it” start? How do you get to the point where your process shows no side effects in the pre-clinical phase, in animals? And when will clinical trials start – in patients? In this episode, you’ll hear about how are blood cells produced acute myeloid leukemia hematopoietic stem cell transplantation...

A specific strain of bacteria might help prevent and even treat colorectal cancer. The studies in animals show potential in treating other cancers, too. You’ll hear about how many bacteria inhabit a human and how much do they weigh (I bet you underestimate their weight) what is a dysbiotic gut microbiome the gut microbiome and its influence on colorectal cancer studies of specific strains of bacte...

Out of 16 000 livers donated in the US, 7 000 are discarded. 14 000 patients are on the waiting list for a transplant. What if we could recondition the 7 000? What if we could treat these livers outside of a human body and transplant to the patients that need them? You’ll hear what’s the ideal liver graft and why there’s a shortage of them how to keep a liver alive outside of a human body the poss...

What is your optimal breathing rhythm for relaxing? How to make sure it is exactly for you? How to sleep better with a sensor on your chest? Today you’ll hear about sleeping better by tracking your sleep breathing exercises for anxiety, stress, panic attacks HRV or heart rate variability and ECG in a T-shirt smart textiles a sensor that detects how you breathe and when you drift off and Alex’s exp...

Take a plastic chip, a bunch of cells, add some real complex engineering and cellular biology science and you'll have a lung-on-a-chip that can breathe as if in a human body. You're ready to test drugs, as if on people, instead of mice on organs-on-chips. In this episode, you’ll hear about the biology of breathing, down to the cellular level, how to better predict drug responses in human...

You cannot underestimate the emotion when you can feel the warmth of someone’s hand in the hand you do not have. Or cold in the fingers you have not had for years. In this episode, you’ll hear about how people with an amputated hand, can feel the temperature in their phantom hand why you don’t really feel wet or can be tricked into feeling wet when there’s no wetness how do you feel the temperatur...

Imagine breathing into a small tube for a few minutes, then your breath aerosol is sent for a PCR analysis. Quick you'll have the result: bacteria or virus causing pneumonia and can have the right treatment prescribed. You’ll hear how tricky it is to detect bacteria and viruses in the breath why so many pneumonia cases are deadly what is an electrospun nanofiber filter how to better diagnose...

If you suddenly slide into sepsis, there’s a 50% chance you’ll survive. Because it is so hard to detect it. Lab-on-Skin works to change it. And has the Mayo Clinic on their side. Today you’ll hear about continuous shock monitoring – to detect the earliest symptoms of sepsis how to assess sepsis nanotechnology, nanoelectronics, nanofluidics and the unexplored wealth of our interstitial fluid Esmera...

When do you think you start aging? Age-related mitochondrial decline, one of the reasons for aging, starts in your 30s and 40s. Pretty early, huh? Is this a moment to think about longevity supplements? Today you’ll hear about longevity and healthy aging improving your healthspan from the cellular level mitophagy and how to amp it up the power of pomegranates and berries why not all of us can unlea...

Older biological age is associated with  higher mortality  and various age-related diseases. What can you do if you know that you look older, feel older, are older biologically than the date of birth on your passport? What can you do with your test biological age? You’ll hear about longevity and healthspan chronological vs biological age what is an epigenetic clock how to measure biological age wh...

If you miss your glaucoma appointment in the UK, you could partially go blind while waiting for the next one. How about taking the test by yourself at home with a VR headset? You’ll hear about why banging into objects can be both glaucoma early symptoms, and late ones why many people don’t even realize they have glaucoma how glaucoma is diagnosed now, why it is so frustrating how coffee can impact...

Instead of or before a genetic test – a blood smear analysis to detect blood cancers might soon be an option. What a human eye cannot see – also under a microscope, computer vision + AI can. You’ll hear about cancer diagnostics in highly specialized centers why is Next-Generation Sequencing so expensive how AI and computer vision can help bring personalized cancer medicine to millions of patients...

You don't see your bones melting in a hot bath, so usually osteoporosis is diagnosed too late. 20% of people with an osteoporotic fracture will die within a year.  1 woman out of 2 will develop osteoporosis after menopause 1-2 men out of 5 will develop osteoporosis but more men die of the consequences of osteoporosis  Now, this can change. You may act against it earlier. You’ll hear about til...

In your gut microbiome, there is a small family of bacteria that have a super important role to play: activate vitamin B6, regulate obesity, improve your mood, reduce anxiety and stress. You’ll hear about gut microbiome balance, how to achieve it, and how to kill it this small family of gut bacteria, namely Bifidobacteria the role of Bifidobacteria in preterm and full-term infants and in obese tee...

To search for a possibly life-saving ground-breaking treatment for a cancer patient that is available only in clinical trials it takes: personal connections your oncologist network long hours frustration and luck. Ancora.ai wants to change it. Make clinical trials and innovative treatments more accessible for patients. Accelerate the search for patients for clinical trial sponsors. It takes around...

A drug that works for a mouse might not work for a human. How about testing drugs for inflammatory diseases – and cosmetics – on human organoids?  You’ll hear  what are human vascular organoids and how to grow human cells also about  the mechanisms of inflammation and the ability to see where drugs can block it arthritis and other chronic inflammatory diseases personalized medicine cosmetics not t...

If you heard about miraculous CAR-T cell therapies that cure cancer in one go, my guest today works on something one step further: immunotherapies that are manufactured from healthy donor cells. That means a thousand cancer patients may receive in the future a life-saving shot manufactured ahead and administered when needed. You may expect  a fascinating journey into off-the-shelf cell immune ther...

While growing bone organoids, it is apparently important to take bone cells to the gym three times a week. Or – apply mechanical loading, if you want to use more precise language.  You’ll hear about mechanical properties of the human bone how to grow bone organoids and what can you test on them osteogenesis imperfecta called glass bones osteosarcoma bone metastasis and bone density in Roger Federe...

A new wearable is coming to the market in 2024: a smaller ring to track your sleep, stress, calories burnt, and other vitals and activities. Already pre-ordered by over 7000 people. You’ll hear about a smart ring that is smaller than other rings and what fits inside what can you track with it the differences between various wearables: smartwatches, rings how does PPG technology work and how small...

Could a robot perform trachea intubation? How about letting AI guide clinicians and paramedics in inserting the tube into people's airways? You’ll hear what is tracheal intubation and why it is far from putting a straw in a bottle what can go tragically wrong how long do anaestesiologists perfect the skill and how much less some other specializations have training how to train AI in intubatio...