What's Your Problem?

Cement is, almost literally, everywhere. It is extraordinarily useful, which is why humanity makes 4 billion metric tons of it every year. But cement is also extremely carbon intensive to produce. Leah Ellis is the co-founder and CEO of Sublime Systems. Her problem is this: How can you make cement, at scale, without emitting carbon dioxide? See omnystudio.com/listener for privacy information.

Sam D'Amico is the founder and CEO of Impulse Labs, a company that makes induction stoves, with a clever twist. Sam’s problem is this: How do you build an electric cooktop that works just as well as gas, and can be installed without having to rewire the house? The solution that Sam found could eventually help transform not only kitchens, but the way homes draw power from the electrical grid.  See...

Tim Ellis is the co-founder and CEO of Relativity Space, a company with a unique approach to manufacturing rockets. Tim’s problem is this: How can you use 3D printing to make rockets more efficiently? Eventually, Tim wants to send a rocket – and printer – to Mars to build the first Martian industrial base.  See omnystudio.com/listener for privacy information.

Every year in the U.S., tens of thousands of hospital patients die of preventable causes. For many of these patients, warning signs are subtle and easy for doctors to miss. Suchi Saria is the founder and CEO of Bayesian Health, and a professor at Johns Hopkins where she runs a lab focused on machine learning and healthcare. Suchi’s problem is this: How can you use AI to detect when hospital patien...

Gia Schneider is the co-founder and CEO of Natel Energy, a company that is trying to transform the way hydroelectric power works. Gia’s problem is this: how do you draw hydropower from rivers without damaging the ecosystem? As it turns out, we have a lot to learn from nature’s furriest engineers – beavers. See omnystudio.com/listener for privacy information.

Peter Chen is the co-founder and CEO of Covariant. Peter’s problem is this: How do you take the AI breakthroughs of the past decade or so, and make them work in robots? Peter was one of the first employees at OpenAI, the maker of ChatGPT. On the show, he talks about how AI has evolved, and why it's so difficult to teach a robot to fold a towel. See omnystudio.com/listener for privacy information.

Fei-Fei Li is a Stanford computer scientist and the former chief scientist of artificial intelligence/machine learning at Google Cloud. When Li entered the field of AI in the 2000s, researchers were making slow progress, optimizing algorithms to incrementally improve outcomes. Li saw that the problem wasn’t the algorithm, but the size of the datasets being used. So she built a massive database of...

Tim Latimer is the CEO and co-founder of Fervo Energy, a company that is using a new approach to produce carbon-free geothermal energy. Tim and his company are drawing on innovations from the oil and gas industry to expand geothermal energy production to new places like the Utah desert, and maybe one day, to Mars. See omnystudio.com/listener for privacy information.

Manolis Kellis is a professor of Computer Science at the Massachusetts Institute of Technology. He works in computational biology, taking giant datasets relating to genetics and health outcomes and tries to understand what’s going on. Manolis’ research focuses on genomics, and a related field called epigenomics. Manolis’ problem is this: What are the cellular mechanisms of a disease? And how can w...

After working as a chef for decades, Anthony Strong’s dream came true: He opened his own restaurant. His problem was a classic one: Restaurants are bad businesses. So he set out to open a new kind of restaurant, with a new business model. In this episode, he tells us about how he accomplished that with his latest venture, Pasta Supply Co. in San Francisco. See omnystudio.com/listener for privacy i...

Selling hydrogen to make fertilizer is a huge business. It also drives tons of carbon emissions. Rob Hanson, the co-founder and CEO of a company called Monolith is trying to create hydrogen without emissions -- and to do it at scale, at a competitive price. A key tool he’s using: The biggest plasma torch ever built. See omnystudio.com/listener for privacy information.

Frances Frei and Anne Morriss are the co-founders of a training and consulting company called The Leadership Consortium. Together they specialize in helping leaders build trust within their companies. They also co-host a podcast called Fixable , which is a TED show produced by Pushkin Industries. Also, Frances is a professor at Harvard Business School. In today’s show, Frances and Anne share the s...

When a Dutch crime reporter makes an unbelievable discovery, a small-town murder case begins to look like an international assassination plot. Enjoy this episode from Hot Money: The New Narcos , a podcast from Pushkin Industries and the Financial Times.  See omnystudio.com/listener for privacy information.

A few weeks ago, Jacob Goldstein sat down with a writer and a composer on a stage in Chicago to talk about artificial intelligence. The conversation, which was part of the  Chicago Humanities Festival , aimed to answer a big question: will AI kill creativity? The writer, Stephen Marche, is the author of several nonfiction books and novels. Earlier this year he tried something new: he used AI to he...

Jigar Shah is the director of the Loan Programs Office at the U.S. Department of Energy. Last year, as part of the Inflation Reduction Act, Congress allocated hundreds of billions of dollars for Jigar’s office to lend out. The loans are supposed to go to companies that are helping the U.S. economy move away from fossil fuels. That can mean everything from building new nuclear plants to creating a...

Pushmeet Kohli is vice president of research at DeepMind, an AI research group that is part of Google. Every protein has a unique shape. And understanding a protein’s shape is key to understanding how proteins work to keep us healthy, and what goes wrong when we get sick. But, for decades, figuring out the shape of a protein was a hard problem that could take years of work. Then Pushmeet and his c...

Forrest Meyen is the co-founder and Chief Strategy Officer of Lunar Outpost, a company that builds machines that go to places like Mars and, if everything goes according to plan, the moon. The company is betting that the private space boom of the past decade will soon go beyond Earth’s orbit to the moon and beyond. See omnystudio.com/listener for privacy information.

Brannin McBee is the co-founder and Chief Strategy Officer at CoreWeave. A few years ago, he and a few friends started buying hardware to mine cryptocurrency. It turns out, the same hardware -- chips known as GPUs -- is essential for running state-of-the-art AI models. Today, Brannin and his friends have turned their hobby into a company that’s competing against some of the biggest companies in th...

Sam Bankman-Fried, the former crypto mogul, is on trial for fraud. On today’s show, we talk to Lidia Jean Kott, who is covering the trial for another Pushkin show, about a dramatic day in court. Caroline Ellison, former co-CEO of Alameda Research and Sam Bankman-Fried’s ex-girlfriend, took the stand. She recently pleaded guilty to fraud, and is cooperating with the prosecution. Hear Against the Ru...

Christina Smolke is the co-founder and CEO of Antheia. Antheia is a synthetic biology company -- they’re in the business of genetically engineering microorganisms to produce commercial products. Christina’s problem is this: How do you turn yeast cells into tiny factories to create the active ingredients in generic drugs .  If Christina and her team solve this problem, they won’t solve the drug sho...

Stephen Klein is the co-founder and CEO of Hyphen, a company that is developing an automated make line. Stephen's problem is this: How do you make restaurant food from fresh ingredients... cheaper? Chipotle invested in Hyphen, whose automated system could soon be preparing online orders at thousands of Chipotle outlets. See omnystudio.com/listener for privacy information.

Simon Johnson is an MIT economist and the co-author of a new book called “Power and Progress: Our Thousand-Year Struggle over Technology and Prosperity”. Simon’s problem is this: How do you create the conditions for technological change to benefit many people, rather than just a powerful few? See omnystudio.com/listener for privacy information.

Sal Khan is the founder and CEO of Khan Academy. Sal’s problem is this: How do you design an AI that can give students the kind of benefits they’d get from working with a human tutor? Earlier this year, Khan Academy launched Khanmigo, an AI tutor built on top of GPT4.  The idea is to use AI to give more kids access to one-on-one tutoring, and help human teachers with their work as well. See omnyst...

What can we learn from the centuries-long quest to eradicate smallpox, once the scourge of humanity? And how did it set the stage for all vaccines to come? First we meet Edward Jenner, a doctor in 18th century Britain who learned about the folk practice of “variolation” and found a safer way to inoculate people against smallpox. Then, Donald Hopkins of the Carter Center takes us back to the 1960s...

Allon Bloch is the co-founder and CEO of K Health. Allon’s problem is this: Can you use AI to make seeing a doctor easier and more helpful? Today, thousands of patients a month are treated through K Health. The company has an AI-based patient interface and it employs about 150 doctors. And K Health has plans to expand beyond primary care -- and they just raised another 50 million dollars to help t...