Up One

Sawyer Stone and Dr. Bill Andrews demystify the complex relationship between mitochondrial health and the aging process. Dr. Bill breaks down cellular energy, explaining how mitochondria function as the body’s primary power source through ATP production. The discussion moves beyond simple marketing hype to explain how short telomeres act as a "dimmer switch" that can shut down mitochondrial effici...

In this episode of Up One, hosts Sawyer Stone and Dr. Bill Andrews are joined by world-renowned sexual health expert Dr. Amy Killen to explore the profound link between physical intimacy and biological longevity. The conversation breaks down the "four pillars" of sexual health—the mind, hormones, blood flow, and pelvic support—while highlighting research that suggests regular sexual activity can l...

In this frank discussion on Up One, host Sawyer Stone is joined by Dr. Bill Andrews and longevity physician Dr. Sandra Kaufmann to demystify menopause, an event Dr. Kaufmann calls "a canary in the coal mine" for a woman's aging process. They debate the underlying cause, with Dr. Andrews questioning if it's a random genetic accident linked to 'Mitochondria Eve' or a mysterious, non-linear timing me...

In this episode of Up One, hosts Sawyer Stone and Dr. Bill Andrews pull back the curtain on the world of scientific publishing and health claims. Dr. Andrews explains that a standard meta-analysis is insufficient because the peer-reviewed literature is riddled with flawed or even fabricated data, often fueled by the pressure to "publish or perish" or by commercial bias. He defines critical meta-an...

In this episode of Up One, hosts Sawyer Stone and Dr. Bill Andrews are joined by Chief Formulator Christian Chase to break down the science of collagen peptides. They explain that collagen makes up 25% of your body's protein, providing the structural integrity for your bones and skin, and its production is closely linked to telomere length. We clarify the difference between full-length collagen an...

In this episode of Up One, hosts Dr. Bill Andrews and Sawyer Stone cut through the noise to discuss what really impacts your heart's health. Dr. Andrews, with over 40 years of experience in cardiovascular research, tackles common myths about fats, detoxes, and exercise. He reveals surprising facts about the benefits of specific antioxidants and the hidden dangers of certain oils, based on his crit...

In this episode of Up One, host Sawyer Stone and molecular biologist Dr. Bill Andrews return to the fascinating subject of aging, moving beyond the myths to focus on the tangible science of telomeres. Dr. Andrews shares the personal story that ignited his career and explains his "ride tickets" and "tug-of-war" analogies for telomere shortening and lengthening. He reveals how his lifestyle, from ul...

Many of us think blood sugar is only a concern for diabetics, but as Dr. Bill Andrews explains, glucose regulation plays a pivotal role in everyone's overall health. In this episode of Up One, Dr. Bill and co-host Sawyer Stone dive deep into the science of blood glucose, exploring how everything from the foods we eat to our daily habits can impact energy, cognitive function, and even the aging pro...

Why, despite decades of research and billions in funding, do diseases like cancer, Alzheimer’s, and heart disease remain uncured? In this episode, Sawyer Stone and Dr. Bill Andrews explore the scientific, economic, and institutional barriers that stand in the way of true medical breakthroughs. From the politics of research funding to the myths about superfoods and supplements, this conversation se...

What if aging isn’t just inevitable, but a solvable biological puzzle? In this inaugural episode of Up One , hosts Sawyer Stone and Dr. Bill Andrews take a deep dive into the science of aging—from the cellular wear and tear that kicks off the process to the role of telomeres, telomerase, and lifestyle choices in determining how long (and how well) we live. Dr. Bill breaks down the hard science beh...

Welcome to Up One , the podcast that cuts through the noise in health and wellness. Join host Sawyer Stone and longevity scientist Dr. Bill Andrews as they dive into the real science behind today’s most talked-about supplements, therapies, and diagnostics. In this trailer, we break down what Critical Meta-Analysis means, what makes our approach different, and why Up One is your trusted source for...