Tucker Goodrich: Debugging Life

Introduction Nick asked me to do a YouTube livestream to go over some research he had been doing. He drilled down on a reference in a high-profile cardiology guideline article and discovered that the authors had inverted the research finding in the referenced paper to claim the inverse of what it actually showed. We discussed this, and then I gave some more context about the matter and one of the...

Introduction It's well-known that lipid peroxidation is involved in aging and longevity. But what can we do about it? Dr. Shchepinov has been researching using deuterium to 'shore up' the PUFAs like those in seed oils to prevent them become toxic metabolites. He's had some interesting successes, and we discuss at length his new book: "Breaking the Chains of Aging". Amazon link: https://amzn.to/46A...

Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, "Total Daily Energy Expenditure Has Declined Over the Past...

Introduction So apparently there is some demand for discussion/debate on the topic of seed oils and health. Dave Feldman (Ep. 9) had considered doing this at his recent conference, but couldn't fit in the time. He's since regained interest in the idea, and reached out to Andreas Eenfeldt and Ted Naiman, who have expressed skepticism. They replied: "We decline as we feel this debate is a distractio...

Introduction I am honored to be joined by John Speakman, a leading authority on energy balance in animals, and in the use of the doubly-labeled water method of determining energy balance. This has led him into the study of obesity, among other topics, where he has become a recognized expert. Our discussion was prompted by his recent paper, "Total Daily Energy Expenditure Has Declined Over the Past...

Introduction Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people. It's obviously important to understand what environmental factors might affect our susceptibility to the various cancers. Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysf...

Introduction What about fish oil? Is it a problem due to oxidation and contamination? Is it beneficial to health as many claim or is it a PUFA that's bad for your health? Jacob recently published an analysis of various fish oils with the team at Consumer Labs, looking at oxidative toxicity and purity of a wide variety of commercially available fish oils. We discuss omega-3 and health, fish oils an...

Diabetes, broadly defined, afflicts greater than 50% of the U.S. population. The hallmark of type 2 diabetes is insulin resistance. While many are unable to answer the question of why a formerly rare disease now afflicts the majority of the population, we go over research dating back to 1964 that makes it clear that we have a pretty good idea of what causes insulin resistance. Scientists can easil...

Introduction We're honored to be joined today by Autumn Smith of Paleovalley and John Etchart of Wild Pastures. These related companies (John is Autumn's brother-in-law) work to deliver healthy, regeneratively-farmed foods to their customers. " At Paleovalley, our mission is to help people reclaim vibrant health. We provide products that prioritize nutrient density in an industry that prioritizes...

Introduction We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have. This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes. "The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine...

Introduction We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life. "In Omega Balance , noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imba...

Introduction We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand. This w...

Introduction Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture. We also have an extens...

Introduction We're trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt's a smart guy but he's not as immersed in these topics as we are, and so he's going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss. In our inaugural episode we discuss "Brief Episode of STZ-Induced Hyp...

We interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician's assistant, through becoming the "Carnivore MD", to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impacted his health and his ideas about being a physic...

Dr. Kerley and I are joined by Dalton Graham, a student who found himself in a liver pathology lab at Tulane. He had the interesting idea to test if a high-linoleic acid diet could be shown to produce fatty liver disease at the same time it was causing obesity. The scientists in the lab required a little convincing that this was a worthy experiment, but one day he arrived to find all the materials...

Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows.   Youtube: https://youtu.be/amwNvHHmy4o Rumble: X: Podcast: Topics: Basic theory of CVD causation:   ·          High ApoB/LDL/Cholesterol ·          Gradient causes penetration of arterial wall ·          Cholesterol/lipid oxidation in wall...

Discussion with Paul Hart, formerly of Unilever and currently a consultant to the processed food industry, on the pros and cons are of processed foods, and what the food industry is hoping to accomplish.

Medicine needs to be fixed: "The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents" ·          https://jamanetwork.com/journals/jama/article-abstract/2802602   Dr. Tro Kalayjian Dr. Tro's Medical Weight Loss ·          https://doctortro.com/ Research: ·          https://scholar.google.com/citations?user=ByYma7sAAAAJ Twitter: ·          https://twitter.com/DoctorTro Dr. Br...

Dr. Durham is a Family Physician in Boise, Idaho; and is Tucker's doctor. We discuss how his practice has changed since he figured out how to solve his own chronic health problems, how this has changed his practice, some successes, and more. Joshua Durham, DO • https://www.saintalphonsus.org/provider/joshua-durham Blog comment: Dr. Durham: "If you need a family Dr. here in Boise hit me up. I went...

Human results of a low-linoleic diet with adequate omega-3 on neurodevelopment. The WHO change their guidelines. How to protect against blindness. Why the Dietary Guidelines can't get it right, and where they do. Fish vs fish oil for omega-3 DHA benefits. Fish consumption and mercury, is it a problem? Farmed vs. wild-caught fish. On the essentiality of linoleic acid. Linoleic acid impairs fertilit...

Jayne Rees Buxton, author https://thegreatplantbasedcon.com/books Amazon: "The Great Plant-Based Con"  https://amzn.to/3PdeV7A Using these Amazon link suppports this podcast, so thank you! Amazon hardcover link (UK site):  https://www.amazon.co.uk/dp/1408717441 Twitter https://twitter.com/JayneReesBuxton _______________________________________ Youtube version: https://youtu.be/X4BrcUyIci0 Co-host...

Brian and I have an engaging chat with famed Paleo Diet advocate Robb Wolf on his recent book 'Sacred Cow', how his own health issues have kept him engaged in continuing to explore the relationship between diet and health, how he's going beyond Paleo with his new enterprise LMNT, and more. I hope you all enjoy! Video for this episode: https://youtu.be/rrQ8q_ctGUQ Robb Wolf https://robbwolf.com/ "S...

I interview Prof. Ameer Taha of U.C. Davis on linoleic acid, lipid peroxidation, oxLAMs, and neurodegeneration. A great discussion going over some of the seminal research he has done during his career. We also discuss his surprising dream research project, one I think would yield major benefits if he were able to pursue it... This was originally released on David Gornoski's A Neighbor's Choice pod...