This Week in Virology

Hosts:  Vincent Racaniello ,  T. Jack Morris ,  James Van Etten , and  Charles Wood Vincent travels to the University of Nebraska to meet with members of the Nebraska Center for Virology and discuss their work on algal viruses, plant viruses, HIV and Kaposi's sarcoma herpesvirus. Links for this episode: The  Nebraska Center for Viology Behind the scenes at TWiV 202 TWiV on Facebook Weekly Science...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Vincent, Alan, Rich, and Kathy answer reader email about rabies, xenotransplantation, poliovirus, Ph. D. programs, mosquitoes, and much more. Links for this episode: Mattias Schnell Novel rhabdovirus  from Africa (Plos Path) Milwaukee protocol  (Wikipedia) How lethal  is rabies virus? (virology blog) Issues with  polio er...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit ,  Elke Mühlberger ,  Paul Duprex , and  Ron Corley Vincent, Alan, and Rich celebrate the 200th episode of TWiV by visiting the National Emerging Infectious Diseases Laboratories at Boston University Medical Center, where they meet with Elke, Paul, and Ron to talk about building and working in a BSL4 facility. Links for this episode: The  NEID...

Hosts:  Vincent Racaniello  and W. Ian Lipkin Vincent and Ian review a multicenter blinded analysis which finds no association between chronic fatigue syndrome/myalgic encephalomyelitis and XMRV or polytropic murine leukemia virus. Subscribe to TWiV (free) in  iTunes , at the  Zune Marketplace , by the  RSS feed , by  email , or listen on your mobile device with the  Microbeworld app . Links for t...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Vincent, Alan, Rich, and Kathy discuss recent outbreaks of hantavirus pulmonary syndrome in Yosemite National Park and novel swine-origin influenza in the US midwest, and isolation of the Heartland virus from two patients in Missouri with severe febrile illness. Subscribe to TWiV (free) in  iTunes , at the  Zune Marketpla...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Vincent, Alan, Rich, and Kathy review fatal avian influenza virus in harbor seals, and poxvirus deployment of genomic accordions to counter antiviral defenses. Links for this episode: Avian influenza virus in  harbor seals  (mBio) Poxvirus  genomic accordions  (mBio) Red Queen hypothesis  (Wikipedia) TWiV on Facebook Lett...

Hosts:  Vincent Racaniello  and  Philip I. Marcus Vincent travels to the University of Connecticut to meet up with Professor Philip I. Marcus to discuss his development of the single cell cloning technique in the early 1950s. Links for this episode: Cloning with  X-irradiated feeder cells  (PNAS) Philip I. Marcus  in the lab  (jpg) Cloning with  capillary tubes  (jpg) Cloning platform  (jpg) VRR h...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit ,  Dickson Despommier ,  Kathy Spindler ,  Mark Stenglein , and  Joseph DeRisi The TWiVites meet with Mark Stenglein and Joseph DeRisi to discuss their discovery of a novel arenavirus in snakes with inclusion body disease. Links for this episode: Highly divergent  arenaviruses in snakes  (mBio) Taryn's sick snake  (NPR) Assemblathon Faculty po...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit ,  Dickson Despommier , and  Ken Stedman The complete TWiV team meets with Ken Stedman to discuss the discovery in Boiling Spring Lake of a DNA virus with the capsid of an RNA virus. Subscribe to TWiV (free) in  iTunes  , at the  Zune Marketplace , by the  RSS feed , by  email , or listen on your mobile device with the  Microbeworld app . Link...

Hosts:  Vincent Racaniello ,  Matthew Daugherty , Jondavid deJong, Helen Lazear, Stefan Oliver, and  Cara Pager . Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers. Subscribe to TWiV (free) in  iTunes  , at the  Zune Marketplace , by the  RSS feed , by  email , or listen on your mobile device with the  Microbeworld app . Links for this episode...

Hosts:  Vincent Racaniello ,  Rich Condit ,  Carolyn Coyne , and  Sara Sawyer Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection. Subscribe to TWiV (free) in  iTunes  , at the  Zune Marketplace ,...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Rich Condit Vincent, Alan, and Rich answer listener email about bioinformatics, insects, influenza, laboratory classes, commensalism, reproducibility of data, and more. Subscribe to TWiV (free) in  iTunes  , at the  Zune Marketplace , by the  RSS feed , by  email , or listen on your mobile device with the  Microbeworld app . Links for this episode: Va...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Nissin Moussatche Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses. Subscribe to TWiV (free) in  iTunes  , at the  Zune Marketplace , by the  RSS feed , by  email , or listen on your mobile device with the ...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Vincent, Alan, and Kathy review selection of influenza H5N1 viruses that can transmit among ferrets by aerosol. Links for this episode: Airborne transmission  of H5N1 among ferrets (Science) Potential  for H5N1 evolution (Science) H5N1  (Science) The ferrets of fear Jim's  podcast list  (pdf) TWiV on Facebook Letters read  on TWiV 190 W...

Vincent returns to the Centre for Virus Research at the University of Glasgow and meets with postdocs to discuss their science and their careers. Links for this episode: MRC-University of Glasgow Centre for Virus Research Stop CMV Photos of my Glasgow visit ( Facebook  and  VirusTalk ) TWiV on Facebook

Hosts:  Vincent Racaniello ,  Massimo Palmarini ,  John MacLauchlan ,  Emma Thomson , and  Hande Harmanci . Vincent travels to Scotland to meet with members of the Centre for Virus Research at the University of Glasgow to discuss their work on hepatitis C virus and jaagsiekte sheep retrovirus. Links for this episode: MRC-University of Glasgow Centre for Virus Research Aaron Shatkin, 77  (virology...

Hosts:  Vincent Racaniello  and  Rich Condit Vincent and Rich discuss recovery of a hepatitis B viral genome from a 16th century Korean mummy, and personal omics profiling of an individual over a 14 month period. Links for this episode: Tracing HBV to the  16th century  (Hepatology) HBV on TWiV Precautions with  ancient DNA  (Science) Personal omics profile  over 14 months (Cell) A geneticist's re...

Hosts:  Vincent Racaniello , Alan Dove, and Rich Condit The TWiV chiefs tackle reader email about how to pronounce Buda, Texas, grinding tree stumps, and much more. Links for this episode: Detecting antibodies or antigens by  ELISA Peter Wildy Prize Biosafety levels Baltimore classification  at Viral Zone TWiV on Facebook Letters read  on TWiV 186 Weekly Science Picks Alan -  World Wide Lightning...

Vincent visits with members of the Department of Microbiology and Immunology at Northwestern University School of Medicine to discuss their work on herpesviruses and parainfluenzaviruses. Links for this episode: Longnecker laboratory Herpesvirus deubiquitinase is  neuroinvasive determinant  (PLoS Path) Paramyxovirus HN  structure  (PNAS) TWiV on Facebook Letters read  on TWiV 185 Weekly Science Pi...

Vincent, Rich, and Alan consider how to reform the scientific enterprise to make it more effective and robust. Links for this episode: Reforming science:  Methodological and cultural reforms  (Infect Immun) Reforming science:  Structural reforms  (Infect Immun) Sharp rise in  retractions  (NY Times) Vannevar Bush TWiV on Facebook Letters read  on TWiV 184 Weekly Science Picks Alan -  PubMed PubReM...

Connor joins the TWiV team to discuss bats as hosts for major mammalian paramyxoviruses. Links for this episode: NIH response  to Osterholm letter (pdf) Who's afraid of the  big, bad bioterrorist? Bats host major  mammalian paramyxoviruses  (Nature Comm) TWiV on Facebook Letters read  on TWiV 183 Weekly Science Picks Connor -  Microbiology Twitter journal club Alan -  Where the Wild Types Are  (Yo...

Hosts:  Vincent Racaniello ,  Rich Condit ,  Alan Dove , and  Michael J. Imperiale Michael joins the TWiV crew to discuss the recently published influenza H5N1 transmission paper and how it was viewed by the NSABB. Links for this episode: About the  NSABB The  Kawaoka paper  (Nature) Mutant flu  paper published (Ed Yong) Osterholm letter  (pdf) US policy for  dual research of concern  (pdf) TWiV o...

Hosts:  Vincent Racaniello ,  Rich Condit , and  Kathy Spindler Vincent, Rich, and Kathy discuss Cotia virus, a new poxvirus, Orf virus infections associated with handling goats and lamb, and the innate immune response to prions. Links for this episode: Cotia virus  (J Virol) Human  Orf virus exposures  (MMWR) IRF3 protects agains  prion infection  (J Virol) A  mad cow  in America (virology blog)...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Rich Condit Vincent, Alan, and Rich review association of an interferon-induced protein with severe influenza, and stabilization of HCV RNA by a microRNA. Links for this episode: IFITM3 and  severe influenza  (Nature) Genetics of  flu susceptibiligy  (EurekAlert!) Stabilization of HCV RNA by  Ago2-miR-122  (PNAS) Clinical trial of  anti-mIR-122 TWiV o...

Hosts:  Vincent Racaniello , Alan Dove, Rich Condit, and  G ertrud Radu Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps. Links for this episode: Renato Dulbecco , 1914-2012 (virology blog) William Jarrett , 83 (thanks, Lynn Enquist) Dengue virus infection of mosquitoes  alters their beha...