This Week in Virology

Hosts:  Vincent Racaniello , Alan Dove, Rich Condit, and  G ertrud Radu Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps. Links for this episode: Renato Dulbecco , 1914-2012 (virology blog) William Jarrett , 83 (thanks, Lynn Enquist) Dengue virus infection of mosquitoes  alters their beha...

The TWiValians meet up with Tyler Sharp for a discussion on the Epidemic Intelligence Service and controlling dengue. Links for this episode: 2010  dengue epidemic  in Puerto Rico Marshall Islands dengue outbreak ( one  and  two ) Photo of Tyler by  Loren Rodgers TWiV shout-out by  NPR  and  CIDRAP NSABB  reverses decision  on H5N1 publication TWiV on Facebook Letters read  on TWiV 178 Weekly Scie...

A discussion of avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland. Links for this episode: Restricted data  on H5N1 transmission (Science) Novel bunyavirus in China ( NEJM  and  TWiV 127 ) Ten things about  Schmallenberg virus  (Microbiology Bytes) NSABB  reverses decision  on H5N...

Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more. Links for this episode: More than one way to skin a virus ( comments ) Aerobie aeropress Papers  software Vaccinia movies ( one  and  two ) Lloyd Kozloff  dies BSL4 facilities TWiV on Facebook Letters read  on TWiV 176 Weekly Science Picks Rich  - Alan Alda's  Flame Challenge...

Vincent, Alan, and Matt discuss herpes simplex encephalitis in children with innate immune deficiency, and the local response to microneedle-based influenza skin immunization. Links for this episode: Herpes encephalitis in children with  TRIF deficiency  (J Clin Inv) Toll-like receptor  and  cytosolic  pattern recognition receptors Skin responses to influenza  microneedle vaccine  (mBio) Microneed...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Rich Condit Vincent, Alan, and Rich consider whether pet dogs might transmit human noroviruses, and an RNA virus microRNA that might be involved in oncogenesis. Links for this episode: Do pet dogs transmit  human norovirus ? (J Clin Virol) RNA virus miRNA  that mimics oncomiR (PNAS) MicroRNA expression by  an RNA virus  (PNAS) Lab safety stickers  jpg...

The TWiVites discuss seroevidence for human infection with avian influenza H5N1, and the discovery of a new influenza virus in Guatemalan bats. Links for this episode: Seroevidence for  human H5N1 infection  (Science) Mammalian-transmissible  H5N1 (mBio) New information about ferret-adapted H5N1 ( NY Times ,  virology blog ) New influenza virus  from fruit bats (PNAS) Elsevier abandons  open acces...

Hosts:  Vincent Racaniello  and  Kathy Spindler Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor. Links for this episode: Celsius vs Centigrade Neuropathogenesis during  polymicrobial infection  (PLoS Pathogens) Tetramer staining  (pdf) One TWiV on Facebook Letters read  on TWiV 172

Matt joins the TWiVarians to review virus production in single cells and single virion genomics. Links for this episode: H5N1 results  will be published  (NY Times) Virus production in single cells  then  and  now Single virion  genomics  (PLoS One) Multiple displacement amplification  (Wikipedia) Ranavirus  killing turtles, tadpoles in Maryland (Washington Post) Three Dog Night TWiV on Facebook L...

Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more. Links for this episode: Norton Zinder , 83 (Reuters) Jenner's cowpox vaccine paper ( Bartleby ,  Gutenberg ) Norovirus  VLP vaccine  (NEJM) Plant-grown H5N1 VLP vaccine ( Reuters ,  PLoS One ) Plant-grown  norovirus VLP Hexavalent  pedia...

Michael and the TWiV team review epidemiology basics, including fatality ratios. Links for this episode: Michael's  blog  and  podcast Epidemiology  literature critique  (PowerPoint) Seven mistakes  in epidemiology (ETE) Snow  cholera map TWiV on Facebook Letters read  on TWiV 169

Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted. Links for this episode: Vectored HIV  immunoprophylaxis  (Nature) Vectored immunoprophylaxis -  the Movie  (YouTube) Adeno-associated virus  (Wikipedia) In vitro  evolution of H5N1 towards  human receptor specificity  (Virology) Endogenous...

The complete TWiVome deconstructs the movie Contagion .

Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses. Links for this episode: Niemann-Pick C1 is  entry factor for HCV  (Nature Med) Ebola virus entry requires Niemann-Pick C1 (Nature  one ,  two ) Nectin-4 is measles virus epithelial receptor ( Nature ,  PLoS Pathogens ) An  exit strategy  for measles virus (Science) On this day in h...

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.

Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.

Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.

The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi's sarcoma herpesvirus and Merkel cell polyomavirus.

Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.

Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.

A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.

Vincent, Rich, and Dickson review a meta-analysis on influenza vaccine, a killer virus in fungi that selects against RNAi, and the use of armed and targeted poxviruses for oncolytic virotherapy.

Vincent, Grant, Eurico, Paulo, Francisco and Janice discuss their work on bocavirus, infectious bronchitis virus, begamoviruses, and circoviruses at the Brazilian Virology Society meeting in Atibaia,  São Paulo ,  Brazil.