This Week in Virology

Hosts:  Vincent Racaniello ,  Dickson Despommier , and  Terry Dermody Vincent and Dickson speak with Terry Dermody about his career in medicine and virology. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more. Links for this episode: Plant viruses  alter insect behavior  (Sci Rep) Circovirus in Shanghai Letters read  on TWiV 225 Weekly Science Picks Kathy -  Case stories about CoV-EMC (...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract. Links for this episode: Dipeptidyl peptidase 4  is CoV-EMC receptor (Nature) Receptor for  new coronavirus  (Nature) Broad reception  for coronavirus (Nature...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells. Links for this episode: International Women's Day 2013 Condit Dam,  6 weeks later  (Vimeo) Influenza  HA assay Covalent  influenza NA inhibitors  (Scie...

Hosts:  Vincent Racaniello ,  Rich Condit ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor. Links for this episode: Zhijian J. Chen  (Wikipedia) Sensing the  dark side  of DNA (Science) cGAMP is an  endogenous second messenger  (Science) cGAMP synthase  is a DNA sensor...

Hosts:  Vincent Racaniello ,  Dickson Despommier , and  Kathy Spindler Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV. Links for this episode: Human  transmission  of SFTSV (JID) SFTSV  serosurvey  (EID) SFTSV on  TWiV 147 SFTSV in  Japan  (ProMedMail) SFTSV  mouse model  (PNAS) SBV  infectious DNA and mouse model  (PLoS Path) SBV in  Sweden  (ProMedMail) Letters read...

Hosts:  Vincent Racaniello , Rich Condit,  Alan Dove , and Kathy Spindler Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk. Links for this episode: Influenza splicing  regulates infection  (Cell Reports) Reporting on flu splicing from  NPR ,  BBC ,  NBC Splicing  of influenza RNA 8 (jpg) Bacteriophage T7  remodeling...

Hosts:  Vincent Racaniello ,  Rich Condit , and  Anthony S. Fauci Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases. Links for this episode: Fauci history  (J Clin Inves)   Fauci Pharmacy Anthony Fauci  (Wikipedia) Anthony Fauci:  Unfinished business  (Lens) Send your virology questions and comments (email or mp3 file) to twiv...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Welkin Johnson Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response. Links for this episode:   Kuan-Teh Jeang , 54 Resurrection  of ERVs (Nature) Toll-like receptors  control ERVs  (Immunity) Retroviral  danger from within  (Immunity) Ancient viruses  wreak havoc  (The Scientist) Letters read  ...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Dickson Despommier Vincent, Alan, Rich, and Dickson review influenza vaccines. Links for this episode:   FDA licensed flu vaccines Seasonal influenza vaccine  distributed How flu vaccine strains are selected ( one ,  two ) WHO report on flu  vaccine strain selection  (pdf) Derek Smith on  antigenic mapping Salk's 1945  influenza vaccine...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Rich Condit , and  Kathy Spindler Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export. Links for this episode: Slides  for this episode (pdf) Spliced  Ad 2 late mRNAs (Cell) An  amazing sequence  arrangement (Cell) Adenovirus late mRNA  undecanucleotide  (Cell) Aaron Shatkin, 72  (virology b...

Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East. Links for this episode: Neuronal survival  after rabies virus infection (PLoS Path) Clusters of  coronavirus cases  (Nature) ProMedMail on  novel coronavirus Novel c...

Hosts:  Vincent Racaniello ,  Rich  Alan Dove , and  Kathy Spindler Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons. Links for this episode: Coagulation factor X  activates innate immunity  to adenovirus (Science) A  decorated virus  cannot hide (Science) Reflecting...

Hosts:  Vincent Racaniello ,  Rich Condit ,  Alan Dove , and  Kathy Spindler In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012. Twelve virology stories from 2012: H5N1 (TWiV  190 ,  182 ,  177 ,  173 ,  168 ) Polymorphisms that control susceptibility (TWiV  175 ,  180 ) New virus receptors (TWiV  166 ,  210 ) XMRV: Last nail in the coffin ( TWiV speci...

Hosts:  Vincent Racaniello  and  Stuart Firestein Vincent and Stuart discuss why ignorance - all of what we don't know, and even what we don't know we don't know - is the driving force of science. Links for this episode: Ignorance: How it drives Science  by Stuart Firestein Ignorance  website Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts:  Vincent Racaniello ,  Rich Condit ,  Alan Dove , and  Kathy Spindler The TWiVerers answer listener email about genetically modified chickens, a hendra vaccine for horses, online education, curing color blindness, Roosevelt and polio, Th cells, and much more. Links for this episode: TWiV 116: Cocaine, colonies, and chickens Glofish Recombinant  Hendra vaccine Gene therapy for  color blindne...

Hosts:  Vincent Racaniello ,  Rich Condit ,  Alan Dove , and  Kathy Spindler The TWiV four discuss an mRNA-based influenza vaccine, and a phage tubulin that forms a filamentous array in the host cell that is needed for positioning viral DNA. Links for this episode: mRNA vaccine  against influenza (Nat Biotech) Phage tubulin  assembles dynamic filaments (Cell) Viral skeleton  (The Scientist) Not un...

Hosts:  Vincent Racaniello ,  Rich Condit ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler The complete TWiV team reviews identification of the cell receptor for hepatitis B and D viruses, and the cell enzyme that cleaves the genome-linked protein from picornaviral RNA. Links for this episode: HBV and HDV  cell receptor  (eLIFE) Getting to grips  with hepatitis (eLIFE) Sodium taurocholate...

Hosts:  Vincent Racaniello ,  Dickson Despommier ,  Alan Dove , and  Kathy Spindler Vincent, Dickson, Alan, and Kathy answer listener email about deformed wing virus, West Nile virus, FluMist, influenza in Canada, viruses and the tree of life, and more. Links for this episode: Postcard  from the  ultimate student athlete  (pdf) Fidelity of protein synthesis  (Biochemistry, 5th ed.) Letters read  o...

Hosts:  Vincent Racaniello  and  Jon Yewdell Vincent and is joined by special guest Jon Yewdell to discuss solutions for ending the current crisis in American biomedical research. Links for this episode: How to succeed in science:  Taking the plunge  (Nat Rev Mol Cell Biol) How to succeed in science:  Making discoveries  (Nat Rev Mol Cell Biol) How to succeed in science  (YouTube) Resources  for g...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Matt Frieman , and  Kathy Spindler Vincent, Alan, Matt, and Kathy review the use of silk to stabilize antibiotics and a viral vaccine, and an impaired-fidelity vaccine against SARS coronavirus. Links for this episode: Silk stabilization  of antibiotics and vaccines (PNAS) Impaired-fidelity  coronavirus vaccine (Nature Medicine) Select agent status  and SA...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Dickson Despommier , and  Kathy Spindler Vincent, Alan, Dickson, and Kathy discuss how the innate immune response to viral infection influences the production of pluripotent stem cells, and the diverse mobilome of giant viruses. Links for this episode: Innate immunity and  nuclear reprogramming  (Cell) Viruses affect  cell reprogramming  (The Scientist) C...

Hosts:  Vincent Racaniello  and  Harmit Malik Vincent is joined by special guest Harmit Malik to discuss his work on the evolution of genetic conflict. Links for this episode: Harmit on  YouTube Retroviruses and  mammalian placentation  (PNAS) Paleovirology  (Curr Opin Virol) Evolution among  AIM2-like receptors  (J Exp Med) Poxvirus  genomic accordions  (Cell) Letters read  on TWiV 205 Weekly Sci...

Hosts:  Vincent Racaniello ,  Alan Dove ,  Matt Frieman , and  Kathy Spindler Vincent, Alan, Matt and Kathy review isolation of a new coronavirus from two patients in the Middle East, and expansion of the enteric virome during simian AIDS. Subscribe to TWiV (free) in  iTunes , at the  Zune Marketplace , by the  RSS feed , by  email , or listen on your mobile device with the  Microbeworld app . Lin...

Hosts:  Vincent Racaniello ,  Rich Condit , and Mark Challberg Vincent and Rich meet up with Mark Challberg to talk about his scientific career studying viral DNA replication, and his transition to an NIH Program Officer. Subscribe to TWiV (free) in  iTunes , at the  Zune Marketplace , by the  RSS feed , by  email , or listen on your mobile device with the  Microbeworld app . Links for this episod...