This Week in Virology

The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove ,  Rich Condit , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Norovirus o...

The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove ,  Rich Condit , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn Schoo...

From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation. Hosts:  Vincent Racaniello , Dickson Despommier , Rich Condit , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 ASV Job Site revamped Support Viruses & Cells Gordon Conference Faculty positions at I...

  Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'. Host:  Vincent Racaniello Guest: Sandra Urdaneta-Hartmann Become a  patron  of TWiV! Links for this episode CD4 Hunter iOS Android Sandra on Twitter Carla Brown on Twitter Inactivation of HIV in breast milk (Retrovirology) Nipple sh...

The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 ASV 2018 Microbiology Student Symposium at UC Be...

At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers. Host:  Vincent Racaniello Guests: Dominique Carter , Sid Grossberg , John Kirby , Scott Terhune , and Vera Terakanova Become a  patron  of TWiV! Intro music by  Ronald Jenkees Send your virology questions and comments to twiv@microb...

Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more. Host:  Vincent Racaniello Guest: Sean Whelan Become a  patron  of TWiV! Links for this episode Ebola virus entry requires the cholesterol transporter Niemann-Pick C1  (Nature) Lassa virus entry requires a trigger-induce...

The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Kathy Spindler , and Brianne Barker Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 Insulin-like peptides in Iridovirus genomes (PNAS) Dicer-2 d...

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Kathy Spindler , and Brianne Barker Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 Tailed giant Tupanvirus (Nat Commun) Soda Lakes (Wikipedia) Dampened STING in ba...

Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells. Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode USA Science and Engineering Festival Genital inflammation and antiviral effectiveness (Nat Med) Single cell infection heterogeneit...

The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove ,  Kathy Spindler , and Brianne Barker Become a  patron  of TWiV! Links for this episode USA Science and Engineering Festival Ebolavirus infection without an outbreak (J I...

The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode HaHa influenza virus (mBio) MERS coronavirus intestinal transmissio...

Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Guest: Scott Hensley Become a  patron  of TWiV! Links for this episode Weekly influenza surveillance (CDC) Influenza vaccination status (CDC) H3N2 glycosylation site...

The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and a fungus in the mosquito gut that aids dengue virus replication. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode Innate immune detection of capsid patterns (mBio) Mosquito gut fungus aids dengue virus replicati...

The TWiV team explains how infectious horsepox virus - likely the ancestor of smallpox vaccines - was recovered from chemically synthesized DNA fragments. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Potential Zika virus related birth defects , USA (MMWR) Borderi...

The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA  within vesicles across the synapse. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Arc virus-like particles transport RNA across the synapse ( mammalia...

Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Guest: Nels Elde Click arrow to play Download  TWiV 476  (63 MB .mp3, 105 min) Subscribe (free):  iTunes , ...

In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Virology stories of 2017 - in no particular order A virologist in space - TWiV 444 Cool things viruses do:  Astrovirus capsids are enterotoxi...

The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth's waters. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Support Microbe.tv Anti-dengue antibody and disease (J Inf Dis) Bodo saltans virus (biorXiv) Kinetoplast...

The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove ,  Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Support Microbe.tv NEIDL is approved NIH lifts GOF morator...

Vincent speaks with professional podcast producer Ray Ortega about his career and the power of the podcast. Host:  Vincent Racaniello Guest: Ray Ortega Become a  patron  of TWiV! Links for this episode Ray on Twitter The Podcasters' Studio Produce Picker Podcast Ray's YouTube channel Intro music is by  Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv

The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove ,  Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Support Microbe.tv Origin of poxvirus membrane (PNAS) Poxvirus movies: Movie S1 ,  Movi...

The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove ,  Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Sanofi update on D engvaxia Trouble for dengue v...

The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues.  Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove ,  Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode Transcytosis of bacteriophage across cell layers (mBio) Image credit Letters read on TWiV 470 This episode is brought to you...

The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove ,  Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode Phytopathogenic fungus hosts a plant virus (PNAS) Franklin column (PNAS) Potato famine mystery solved (History) Protein Data Ban...