This Week in Virology

Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex. Hosts:  Vincent Racaniello , Dickson Despommier ,  Rich Condit ,  Kathy Spindler , and Brianne Barker Guests: Leonid Yorkovetskiy and Jeremy Luban Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a ...

The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Bark...

The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode Sea...

From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus. Host:  Vincent Racaniello Guest: Harry Greenberg Subscribe (free):  iTunes ,  Google Podcasts ,  RSS ,  email Become a  patron  of TWiV! Links for this episode 13th dsRNA Virus Symposium Hepatitis i...

Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit ,  Brianne Barker , and Anne Simon Click arrow to play Download  TWiV 512  (62 MB .mp3, 103 min) Subscribe (free):  iTunes ,  Google Pod...

Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Ned Landau Become a  patron  of TWiV! Links for this episode Support Viruses Gordon Conference TWiV #1 24 September 2008 SAMHD1 restricts...

Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1. Hosts:  Vincent Racaniello  and  Dickson Despommier Guests: John Coffin , Stephen Hughes , Ya-Chi Ho , and Matt Takata Become a  patron  of TWiV! Links for this episode Cold Spring Harb...

The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia  with the largest RNA genomes. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove ,  Kathy Spindler  and Brianne Barker Become a  patron  of TWiV! Links for this episode Support Viruses Gordon Conference KNAW Beijerinck Prize Bioterrorism and Biocrimes by Seth Carus (free...

Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector. Hosts:  Vincent Racaniello , Dickson Despommier ,  Rich Condit , and  Kathy Spindler Guest: Jens Kuhn Become a  patron  of TWiV! Links for this episode Russia's Bioweapons...

The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Become a  patron  of TWiV! Links for this episode Support Viruses...

David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. Host:  Vincent Racaniello Guest: David Tuller Become a  patron  of TWiV! Links for this episode Article by Lubet and Tuller (STAT) David's Australian trip (virology blog) Sir Simon scores own goal  (virology blog) Lightning process (virology blog) Le...

The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring  Wolbachia . Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , and Brianne Barker Become a  patron  of TWiV! Links for this episode Support Viruses & Ce...

The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Become a  patron  of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Trump picks science...

The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Brianne Barker Become a  patron  of TWiV! Links for this episode Support Viruses & Cells Gordon Conference TWiV 501: Outbreak Nipah virus infection (JCM) Anatomy of an outbreak (The Hindu)...

Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants. Hosts:  Vincent Racaniello , Rich Condit , and  Kathy Spindler Guests: Svetlana Folimonova and Anne Simon Become a  patron  of TWiV! Links for this episode Simon laboratory Folimonova laboratory CTV superinfection exclusion (Virol...

The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria. Hosts:  Vincent Racaniello , Alan Dove , Rich Condit , and  Kathy Spindler Guests: Jason Gill and Ry Young Become a  patron  of TWiV! Links for this episode Center for Phage Technology at TAMU Personalized phage ther...

Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World. Host:  Vincent Racaniello Guests: Sabrina Sholts , Jon Epstein , and Ed Niles Become a  patron  of TWiV! Links for this episode Sabrina Sholts Jonathan Epstein EcoHealth Alliance Outbreak at the Smithsonian ASM partners with Smithsonian (b...

The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and  Kathy Spindler Guests: Jinny Suh , Jason McClellan , and  Jon Huibregtse Become a  patron  of TWiV! Links for this episode A big list of science podcasts Immunize Texas McCl...

Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research. Hosts:  Vincent Racaniello and Alan Dove Guests: Nathalie Grandvaux , Craig McCormick , Kate O'Brien , and Ryan Noyce Become a  patron  of TWiV! Links for this episode TWiV 20...

Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research. Hosts:  Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Stacy Horner and Ken Stapleford Become a  patron  of TWiV! Links for this episode TWiV 2018 World Tour RNA modifications go viral (Plos Path) N6-methyladenosine in flavivirus...

At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research. Hosts:  Vincent Racaniello and  Rich Condit Guests: Sasha Gorbalenya , Jim Hogle , Ann Palmenberg , and Frank van Kuppeveld Become a  patron  of TWiV! Intro music is by  Ronald Jenkees . Send your virology q...

Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction. Hosts:  Vincent Racaniello and  Rich Condit Guests: Stacey Schultz-Cherry , Douglas Diekema , and Andrew Noymer Become a  patron  of TWiV! Links for this episod...

The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conferenc...

Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals. Hosts:  Vincent Racaniello ,  Alan Dove , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Facult...

The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove ,  Rich Condit , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells...