This Week in Virology

Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove ,  Rich Condit , and Kathy Spindler Guest: Amy Rosenfeld Become a  patron  of TWiV! Links for this episode Grad students face tax hike (Nature) House voted to bankrupt grad students (NYTimes) Ne...

Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research. Hosts:  Vincent Racaniello ,  Alan Dove ,and  Rich Condit Guest:  Jon Yewdell and Teddy Yewdell Become a  patron  of TWiV! Links for this episode Jon Yewdell laboratory Chaudhuri laboratory Truth Wins by Jon Yewdell ( epub or mobi download) Noncoding RNAs and class switc...

From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses. Host:  Vincent Racaniello  and Kathy Spindler Guests:  Tuli Mukhopadhyay ,  John Patton , and  Adam Zlotnick Become a  patron  of TWiV! Links for this episode Mukhopadhyay  lab Patton  lab Zlotnick  lab Tuli...

Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove ,  Rich Condit , and  Kathy Spindler Guest:  Theodora Hatziioannou Become a  patron  of TWiV! Links for this episode ASU-UofA Joint Virology Symposium Laboratory of Retroviro...

At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus. Host:  Vincent Racaniello Guests: Katya Heldwein and Sean Whelan Become a  patron  of TWiV! Links for this episode Crystal structure of HSV gB  (Science) Crystal structure of HSV fusion regulator g...

The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove ,  Rich Condit , and  Kathy Spindler Become a  patron  of TWiV! Links for this episode Truth Wins by Jonathan Yewdell ( epub or mobi ) Gabriel Victora awarded MacArthur Prize Forty Years of mR...

David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS. Hosts:  Vincent Racaniello Guest: David Tuller Become a  patron  of TWiV! Links for this episode All of David's ME/CFS articles at virology blog David Tuller on Twitter Through the Shadowlands by Julie Rehmeyer Intro music is by  Ronald Jenkees . Send your virology question...

Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure. Hosts:  Vincent Racaniello Guest: Phillip A. Sharp Become a  patron  of TWiV! Links for this episode Meet the Microbiologist Sharp Laboratory Spliced segments of adenovirus late mRNA  (PNAS) Video of this intervie...

The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits. Hosts:  Vincent Racaniello , Dickson Despommier , Rich Condit , and  Kathy Spindler Guest: Brianne Barker Become a  patron  of TWiV! Links for this episode Meet the Microbiologist TWiV 1 : West Nile Virus Decreasing readability of scientific texts (eL...

Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research. Host:  Vincent Racaniello Guests:  Gary Cohen , Scott Hensley , Carolina Lopez , and Susan Weiss Become a  patron  of TWiV! Links for this episode Cohen Laboratory Hensley Laboratory Lopez Laboratory Weiss Laboratory This e...

The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes ASM Public...

The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes Ro...

Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population. Hosts:  Vincent Racaniello , Dickson Despommier , Alan Dove , and  Rich Condit Guest: Brianne Barker Become a  patron  of TWiV! Links for this episode First genetically engineered salmon sold in Ca...

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor. Hosts:  Vincent Racaniello and  Rich Condit Guest: Brianne Barker Become a  patron  of TWiV! Links for this episode RNA pol III mutations underlie severe varicella (J Clin Inves) Dengue virus activates cGAS by release of...

Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease. Hosts:  Vincent Racaniello ,  Alan Dove , Rich Condit , and Kathy Spindler Guest: Erin Garcia Become a  patron  of TWiV! Links for this episode DNA-based computer explo...

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , and Kathy Spindler Guests: Sharon Isern and Scott Michael   Become a  patron  of TWiV! Links for this episode Hurricane Zika ( TWiV 410 ) 454 Corporation (...

From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system. Hosts:  Vincent Racaniello  and Dickson Despommier Guest: Diane Griffin   Become a  patron  of TWiV! Links for this episode Vector-Borne Viruses Symposium Diane Griffin Adoptive immunization of immu...

Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection. Hosts:  Vincent Racaniello , Alan Dove , and Kathy Spindler Guest: Lynda Coughlan   Become a  patron  of TWiV! Links for this episode Linda on Virus Watch and BSGCT Anti-influenza peptide from frogs...

The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts:  Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler   Become a  patron  of TWiV! Links for this episode Driving past a milestone ( TWiP 100 ) Debug Fresno (Verily blog) What could possibly go wrong? ( TWiV 388 ) Ches...

Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Guest: Ben tenOever Become a  patron  of TWiV! Links for this...

The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , and Kathy Spindler Become a  patron  of TWiV! Links for this episode JMBE SciComm Issue Facial appearance affects science communication (PNAS) Your face matters to...

From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Guest: Mavis Agbandje-McKenna   Become a  patron  of TWiV! This episode of TWiV is sponsored by Pro...

The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions! Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler Become a  patron  of TWiV! Links for this episode JMBE SciComm Issue Female role models in engineering (PNAS) Gender equ...

The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus. Hosts:  Vincent Racaniello , Dickson Despommier ,  Alan Dove , Rich Condit , and Kathy Spindler   Become a  patron  of TWiV! Links for this episode ASM grant writing online course Gender parity trends at virology meetings (J Virol) Pr...

From Nido2017 in Kansas City, Vincent  meets up with three virologists to talk about their careers and their work on nidoviruses. Host:  Vincent Racaniello Guests:  Margo Brinton , Luis Enjuanes , and Linda Saif Become a  patron  of TWiV! Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS...