Matthew
The Synapse Critical Care & Emergency Medicine Podcast
The Synapse is a Critical Care and Emergency Medicine podcast breaking down topics and case studies into simple easy-to-digest segments to help build paramedic, nurse, and other pre-hospital and hospital clinicians into more robust providers. This podcast is open to any and all Emergency Medicine and Critical Care healthcare providers both in and out-of-hospital. Every effort is made to put out as many various topics to cater to everyone's interests and levels. Leave your technician hat outside, put on your clinician hat, and join us! **Disclosures: 1) This is a non-monetary podcast, created...
Where to listen?
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Episodes
The Synapse Season 3 Episode 15 - Driving Pressure 20.01.2026 12:27
Send us Fan Mail No, we aren't going for a drive. Instead, we will look at what driving pressure actually is, and why it is such an important part of mechanical ventilation in general. What tends to trip people up is the strict adherence to one specific equation, when in reality, especially when dealing with Hamilton ventilators, it is just not that simple. Still confused? Tune in and hopeful...
The Synapse Season 3 Episode 7 - The Gregg Phenomenon and the Garden Hose Principle 20.01.2026 14:14
Send us Fan Mail The Gregg Phenomenon? The Garden Hose Principle? What are these? How do they apply to our patients? What specific patients do these apply to? This is a great episode to tune into and learn something that impacts patients almost daily.
The Synapse Season 3 Episode 8 - Emerging Sepsis Filtration Therapies 20.01.2026 10:56
Send us Fan Mail Is sepsis really just about fluids and antibiotics? What if there was something else we could do to actually remove part of the problem and get patients on the road to recovery quicker? Something that could filter out the endothelial damage byproducts? The circulating inflammatory particles? Stay tuned on this episode for a review of some of the newest potential therapies for seps...
The Synapse Season 3 Episode 9 - HFpEF vs HFrEF 20.01.2026 13:04
Send us Fan Mail LVSD vs LVDD...HFpEF vs HFrEF...what is all of this gibberish? This episode looks at the differences between left ventricular systolic vs diastolic dysfunction...in other terms, Heart Failure with Preserved (or Reduced) Ejection Fraction. We will talk about what this means, how to differentiate these, and the differences in treatments.
The Synapse Season 3 Episode 10 - Hypoxic Pulmonary Vasoconstriction 20.01.2026 19:11
Send us Fan Mail What is hypoxic pulmonary vasoconstriction? Is it entirely a bad thing, or can it actually be protective? How do we alter it, and when is altering or blunting it actually a bad thing vs a good thing? Tune in to find out!
The Synapse Season 3 Episode 11 - HACOR Score for Judgement of NiPPV Failure 20.01.2026 12:00
Send us Fan Mail If you have ever put a patient on NiPPV and wondered "Ok, how do I know how long to keep them on, and when do I find out if the patient fails NiPPV and needs to be intubated?," then this episode is for you. HACOR score is useful for EMS and hospital realms as a tool for judging the effect of NiPPV and whether or not you need to intubate the patient. It is validated, easy...
The Synapse Season 3 Episode 4 - PreHospital Blood Programs Don't Need RCT's...Prove Me Wrong 20.01.2026 19:32
Send us Fan Mail I've said this before...there are NO randomized control trials evaluating the safety and efficacy of parachutes...we put our faith in them when we step out of an airplane. With the evidence that already exists out there, both from military and civilian realms, it is absolutely mind-boggling when it comes to the amount of kick-back and resistance that occurs when an EMS agency...
The Synapse Season 3 Episode 5 - Acid-Base Review and the SID 20.01.2026 23:47
Send us Fan Mail It's been a while since we looked at Acid-Base, and I figured now is as good a time as any to really dive into full acid-base interpretation. Brush off your skills, sit back and enjoy a little review if this is something you are very comfortable with, but don't get too comfortable! We will also review something known as the SID, or strong ion difference, and how this als...
The Synapse Season 3 Episode 6 - Influenza and NSTEMI, Cardiomyopathy, and More 20.01.2026 14:42
Send us Fan Mail Can Influenza cause NSTEMI? Cardiomyopathy? Elevated troponins in general? Especially with this nasty flu/respiratory season, expect to see this more and more. What is the mechanism behind this relationship? Are these true NSTEMI's and cardiomyopathies? Do they have lasting effects on the body? Tune in to find out!
The Synapse Season 3 Episode 1 - New Changes and Research for the New Year 01.01.2026 14:01
Send us Fan Mail Welcome back to the Synapse! We are starting Season 3 off with a look at some of the bigger items, procedures, and changes coming down the line in the medical fields that will impact emergency, interfacility transport, critical care transport, and ICU's around the country in the next year or two. From continuing research on the islet cell therapy for Type 1 Diabetics, to chan...
The Synapse Season 3 Episode 2 - ECCO2R in ARDS 01.01.2026 17:55
Send us Fan Mail By now most of you have probably heard of ECMO, and if you tuned into my Intro to ECMO podcast, you should have a pretty solid understanding of what it is and how it helps oxygenate our patients when traditional methods fail. Well, what about severe ARDS refractory to standard treatments where we need super-lung-protective volumes and minute volumes with Vt's down near 3-4mL/...
The Synapse Season 3 Episode 3 - Are My People Ok? 01.01.2026 36:10
Send us Fan Mail Our healthcare system is broken. Nurses and paramedics are leaving at rates never seen before. Is it really just the pay? The hours? Or is there something a bit more obvious, but often shunned or denied, that is part of the driving cause? Are the patients really supposed to be the Number 1 focus of the management, or should it be more along the lines of what Fortune 500 rescuer Ri...
The Synapse Season 2 Episode 100 - When the Brain Attacks the Heart 13.12.2025 17:13
Send us Fan Mail Did you know that seizures can bring about a cardiac arrhythmia in your patient? Have you ever stopped to think about how the brain and heart are connected and how this could occur? In this episode I discuss the anatomy and physiology behind these connections and what can happen in the heart when the brain goes haywire. This is a two-part episode to cap off Season 2 of The Synapse...
The Synapse Season 2 Episode 100a - AVNRT vs AVRT...The Re-Entrant Duel 13.12.2025 23:00
Send us Fan Mail Piggybacking off of episode 100, we examine AVNRT and AVRT, two types of PSVT's that can be brought on by seizure activity, or just from other causes, as well as each of their own specific sub-types. I discuss how to identify them on ECG and how each one will be affected by Adenosine, Procainamide, and other treatments. For those who are primarily treating arrhythmias in thei...
The Synapse Season 2 Episode 97 - PIFT vs CCT...A Hospital "How-To" 12.12.2025 27:01
Send us Fan Mail The world of PIFT protocols vs CCT can be a very confusing place for sending hospitals to dwell in and navigate. Some crews are able to take patients at higher levels of care needs than others. Some don't have the same training or experience, or more importantly, the confidence and comfort levels. Many PIFT paramedics have been pressured or even threatened in their career eit...
The Synapse Season 2 Episode 98 - Adrenal Stress Dosing 12.12.2025 10:36
Send us Fan Mail What is a stress dose? Why do the adrenal glands need help? Who exactly needs this, what do they need, and why? All important questions, friends. Join me on this episode and all will be explained!
The Synapse Season 2 Episode 99 - The "Anti-Winters" Formula 12.12.2025 18:38
Send us Fan Mail Ok, we talked about Winters Formula for expected PaCO2 in metabolic acidosis...but what happens if our patient has the opposite issue, and is metabolic alkalosis instead? Is there a magical (albeit empirical) equation to help with PaCO2 prediction there too? Well, ask and thee shalt receiveth! There IS an equation, but it is the lesser-known (and un-named) cousin to Winters Formul...
The Synapse Season 2 Episode 93 - Winters Formula Pearls and Pitfalls 12.12.2025 31:37
Send us Fan Mail How can we determine where a patient with metabolic acidosis *should* be compensating in regard to expected PaCO2? Enter Winters Formula. In this episode we will talk about how it was derived, its strengths and weaknesses, how to use it, and more. You may be surprised by when and how it was derived, and how long we went without any extra evidence to support it. Predicted PaCO2 = 1...
The Synapse Season 2 Episode 94 - The RSI Trial - Etomidate vs Ketamine...Again 12.12.2025 29:22
Send us Fan Mail It feels like Captain Sparrow and Captain Barbosa locked in eternal battle from the first Pirates movie...except it is Etomidate and Ketamine. The study just released purports that Etomidate is better than Ketamine again...but is it? Before we swap sides yet again in this tug-of-war, should we examine this more closely, and maybe also not fail to remember it's not about the i...
The Synapse Season 2 Episode 95 - Sodium Bicarb Can Cause Pulmonary Edema? 12.12.2025 12:44
Send us Fan Mail Many of you that have been following along know I have put several episodes out on Sodium Bicarb, and you also know I don't typically put Sodium Bicarb high up on my Rx list. This episode looks at how NaHCO3 can actually cause or worsen pre-existing pulmonary HTN, just in case we wanted some more reasons to possibly avoid regular usage of the bicarb.
The Synapse Season 2 Episode 96 - VX-800...Goodbye Type 1 Diabetes? 12.12.2025 13:57
Send us Fan Mail Wouldn't it be amazing if Type 1 Diabetics had a cure? What would we see happen to our case load in healthcare from accidental insulin overdoses or hyperglycemia from under-dosing? Would it be that easy if there was an option? VX-880 is a novel islet cell therapy that has shown amazing results so far in the small cohorts and phase 1 & 2 trials, with patients who have rece...
The Synapse Season 2 Episode 90 - Violence Against Healthcare Workers 21.11.2025 34:06
Send us Fan Mail This is never an easy topic to discuss, but we are going to tackle it today. Whether you are EMS/pre-hospital or in the hospital, you are unfortunately involved in some of the most dangerous professions in our country today. Instances of violence, both verbal and physical, are rising. And that is just what is actually reported. What can we do to strengthen ourselves, the job sites...
The Synapse Season 2 Episode 91 - Methoxyflurane vs Nitrous Oxide 21.11.2025 13:51
Send us Fan Mail Nitrous? Sure...but it comes with a host of issues. Methoxyflurane? Wasn't that banned in the US by the FDA? It was...but it's making a comeback globally and stands poised to change inhaled analgesia for good. Want to know more? Join me in this episode as we take a ride on the Green Whistle!
The Synapse Season 2 Episode 92 - Gantacurium...the Paralytic That Almost Could 21.11.2025 11:10
Send us Fan Mail The search for a suitable replacement for Succinylcholine has been ongoing for decades...a non-depolarizing agent that has the same onset and duration times as Succinylcholine, but without all the nasty side effects...wouldn't that be wonderful? Especially if it was reversible??? Enter Gantacurium...well...it almost entered anyways. A bit of stage fright? Not so much. Join me...
The Synapse Season 2 Episode 86 - Beta Blockers and the Metoprolol Mistake 20.11.2025 14:00
Send us Fan Mail We know beta blockers are a staple treatment in outpatient CHF/HFpEF and stable HFrEF patients. However, what is it about the nature of beta blockers that makes them potent killers in the decompensated HFrEF patient? Why do we routinely mix up the two variations of Metoprolol and why is the common Metoprolol Tartate considered the Metoprolol Mistake in HFrEF patients? Listen in to...
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