The Retina Channel Podcast

Dr. Schrag discusses his publication on the prevalence of cardiovascular risk factors in patients who present with Central Retinal Artery Occlusion. Discussed article: Lavin, P., Patrylo, M., Hollar, M., Espaillat, K. B., Kirshner, H., & Schrag, M. (2018). Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. Am J Ophthalmol, 196 , 96-100. doi:10.1016/j.ajo.2018.08.027  

Dr. Jason Hsu discusses the review of patients with PDR who were lost to followup after limited anti-VEGF or PRP treatment and returned for treatment after at least 6 mo. Full reference: Obeid, A., Su, D., Patel, S. N., Uhr, J. H., Borkar, D., Gao, X., . . . Hsu, J. (2018). Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus I...

Drs. Muni and Hillier discuss the results of the PIVOT study that prospectively compared results of pneumatic retinopexy vs. pars plana vitrectomy for repair of rhegmatogenous retinal detachment. This podcast episode is simulcast with the online appearance of the article.  Full reference: Hillier, R. J., Felfeli, T., Berger, A. R., Wong, D. T., Altomare, F., Dai, D., . . . Muni, R. H. (2018). The...

Professor Robyn Guymer from Melbourne, Australia discusses results of the LEAD trial that investigated the use of nanopulase laser for dry AMD. Full reference of the article: Guymer, R. H., Wu, Z., Hodgson, L. A. B., Caruso, E., Brassington, K. H., Tindill, N., . . . Laser Intervention in Early Stages of Age-Related Macular Degeneration Study, G. (2018). Subthreshold Nanosecond Laser Intervention...

Dr. Ozkok describes his publication on the association of Red Blood Cells Distribution Width (RDW) and vision in patients with Central or Branch Retina Vein Occlusion.  Full Reference of the article: Ozkok, A., Nesmith, B. L. W., & Schaal, S. (2018). Association of Red Cell Distribution Width Values with Vision Potential in Retinal Vein Occlusion. Ophthalmology Retina, 2 (6), 582-586. doi:10.1016/...

Dr. Jennifer Sun discusses 5-year results of DRCR.net Protocol S that investigated outcomes of treatment of proliferative diabetic retinopathy using traditional PRP laser vs intravitreal ranibizumab injections.  Full reference: Gross, J. G., Glassman, A. R., Liu, D., Sun, J. K., Antoszyk, A. N., Baker, C. W., . . . Diabetic Retinopathy Clinical Research, N. (2018). Five-Year Outcomes of Panretinal...

Dr. Camiel Boon from Leiden University Medical Center (LUMC) and Amsterdam University Medical Centers in Amsterdam discusses the results of his research work on the comparison of half-dose PDT vs micropulse laser to treat central serous chorioretinopathy. Full reference of the discussed article: van Dijk, E. H. C., Fauser, S., Breukink, M. B., Blanco-Garavito, R., Groenewoud, J. M. M., Keunen, J....

Dr. Chakravarthy from Belfast, UK discusses a secondary analysis of the IVAN Trial to compare effects of intravitreal anti-VEGF therapy on serum VEGF levels with possible trends in system adverse events in the context of wet AMD. Full reference: Chris A.Rogers, Lauren J.Scott, Barnaby C.Reeves, Susan Downes, Andrew J.Lotery, Andrew D.Dick, Usha Chakravarthy for IVAN trial investigators, Serum Vasc...

Dr. Charles Wykoff discusses results of DRCR protocol T ancillary study on plasma free VEGF concentrations after different intravitreal anti-VEGF injections for diabetic macular edema. Full reference of the discussed article: Jampol, L. M., A. R. Glassman, D. Liu, L. P. Aiello, N. M. Bressler, E. J. Duh, S. Quaggin , et al. "Plasma Vascular Endothelial Growth Factor Concentrations after Intravitre...

Dr. Sean Adrean discusses his retrospective analysis of patients with wet AMD who had over 50 anti-VEGF injections. Full reference of the discussed article: Adrean, S. D., S. Chaili, H. Ramkumar, A. Pirouz, and S. Grant. "Consistent Long-Term Therapy of Neovascular Age-Related Macular Degeneration Managed by 50 or More Anti-Vegf Injections Using a Treat-Extend-Stop Protocol." Ophthalmology   (Feb...

Dr. Mark Humayun discusses the results of his team's work on implantation of RPE stems cells placed on a bioengineered surface for dry AMD.  Full reference of the article: Kashani, A. H., Lebkowski, J. S., Rahhal, F. M., Avery, R. L., Salehi-Had, H., Dang, W., . . . Humayun, M. S. (2018). A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci T...

Dr. David Almeida discusses the result of his group's large retrospective analysis of management and outcomes of 40 cases of endophthalmitis from over 258,000 intravitreal anti-VEGF injections.  Full reference: Xu, K., Chin, E. K., Bennett, S. R., Williams, D. F., Ryan, E. H., Dev, S., . . . Almeida, D. R. P. (2018). Endophthalmitis after Intravitreal Injection of Vascular Endothelial Growth Facto...

Dr. Rajeev Muni describes the results of his research on the correlation of cytokine levels (VEGF, ICAM, etc) and the anatomical response to intravitreal ranibizumab for the treatment of diabetic macular edema. Full reference of the article: Hillier, R. J., Ojaimi, E., Wong, D. T., Mak, M. Y. K., Berger, A. R., Kohly, R. P., . . . Muni, R. H. (2018). Aqueous Humor Cytokine Levels and Anatomic Resp...

Dr. SriniVas Sadda discusses development of macular atrophy in an analysis of HARBOR Study which investigated treatment of wet AMD using 0.5 mg and 2.0 mg of Ranibizumab dosing.  Full reference of the discussed article: Sadda, S. R., Tuomi, L. L., Ding, B., Fung, A. E., & Hopkins, J. J. (2018). Macular Atrophy in the HARBOR Study for Neovascular Age-Related Macular Degeneration. Ophthalmology . do...

Dr. David Brown discusses his recent article in Ophthalmology about the role of targeted peripheral retinal laser photocoagulation to lower the treatment burden for diabetic macular edema. Full reference of the article:  Brown, D. M., Ou, W. C., Wong, T. P., Kim, R. Y., Croft, D. E., Wykoff, C. C., & Group, D. S. (2018). Targeted Retinal Photocoagulation for Diabetic Macular Edema with Peripheral...

Dr. M. Ali Khan describes his article on the long term outcomes of 27-gauge vitrectomy for 390 eyes. Full reference of the articles is: Khan, M. A., Kuley, A., Riemann, C. D., Berrocal, M. H., Lakhanpal, R. R., Hsu, J., . . . Regillo, C. D. (2017). Long-Term Visual Outcomes and Safety Profile of 27-Gauge Pars Plana Vitrectomy for Posterior Segment Disease. Ophthalmology . doi:10.1016/j.ophtha.2017...

Dr. Chirag Shah discusses his pilot randomized clinical trial on the application of YAG Vitreolysis to reduce symptoms of floaters associated with Weiss ring. The full reference of the discussed article is: Shah, C. P., & Heier, J. S. (2017). YAG Laser Vitreolysis vs Sham YAG Vitreolysis for Symptomatic Vitreous Floaters: A Randomized Clinical Trial. JAMA Ophthalmol, 135 (9), 918-923. doi:10.1001/...

Dr. Raj Maturi from DRCR.net discusses final results of the DRCR.net protocol U, which investigated addition of Dexamethasone implant to ranibizumab for the treatment of persistent diabetic macular edema. The full reference of the article is: Maturi, R. K., Glassman, A. R., Liu, D., Beck, R. W., Bhavsar, A. R., Bressler, N. M., . . . Diabetic Retinopathy Clinical Research, N. (2017). Effect of Add...

Dr. Charlie Wykoff describes the treat-and-extend (TREX) approach for the treatment of wet AMD. He then explains the study design and the 3-year results of the TREX-AMD trial. The full reference of the article is: Wykoff, C. C., Ou, W. C., Croft, D. E., Payne, J. F., Brown, D. M., Clark, W. L., . . . Group, T.-A. S. (2017). Neovascular age-related macular degeneration management in the third year:...

Dr. Robert Devenyi discusses the 5-year safety and performance results of the Argus II retinal prosthesis implant. He also share his own experience with the device including surgical steps and patient outcomes. The episode logo reflects the retinal images of the 11 devices that he has implanted so far. The full reference of the article is: da Cruz, L., et al. (2016). "Five-Year Safety and Performa...

Dr. Brian Ballios uses his expertise to talk about the article titled "Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration" by Mandai et al. The article reports use of induced pluripotent stems to culture and transplant Retinal Pigment Epithelial Cells in a patient with advanced Age-Related Macular Degeneration.  The full reference to the article: Autologous Induced Stem-Ce...

Dr. Amin Kherani discusses the Clarity study which compares use of intravitreal aflibercept injections versus PRP laser for proliferative diabetic retinopathy. We also briefly discuss DRCR.net protocol S results that compare intravitreal ranibizumab versus PRP laser for the same indication. Full reference of the Clarity article: Clinical efficacy of intravitreal aflibercept versus panretinal photo...