The Peptide Podcast

Today, I want to talk about one of the most common misconceptions surrounding retatrutide and the recent Phase 3 results released by Eli Lilly. If you've seen the headlines, you've probably read that participants lost over 70 pounds or nearly 30% of their body weight. Those results are absolutely impressive and represent one of the most significant advances we've seen in obesity medicine. But ther...

Today, I want to have a conversation about something that is often missing from discussions about weight loss. We live in a world where people are constantly searching for the fastest way to lose weight. Every year there is a new diet trend, a new supplement, or a new social media influencer promising a shortcut to success. And because of this, many people begin their weight loss journey believing...

Today, we're talking about something that catches a lot of people off guard after switching to retatrutide. You may notice that you're feeling hungrier, some of the food noise is starting to creep back in, or your weight loss isn't moving as quickly as it was in the beginning. In some cases, it may even feel like you've hit a plateau. At first, that can seem confusing. After all, retatrutide is on...

MOTS-c is encoded by mitochondrial DNA, which makes it quite unique compared to most peptides, which are usually encoded by nuclear DNA. This peptide helps our bodies adapt to stress, regulate energy production, and maintain metabolic balance—especially when it comes to burning fat and improving overall endurance. Read the Full Episode Transcript: https://pepties.com/mitochondrial-support-from-mot...

GLP-1 agonists, like semaglutide (brand names Ozempic and Wegovy), are peptides that mimic this natural hormone. They're typically used for managing type 2 diabetes and, more recently, for weight loss. These peptides work by enhancing insulin secretion when glucose levels are elevated, slowing down gastric emptying, and reducing appetite. They also help lower blood pressure and stabilize blood sug...

Today, we're talking about sermorelin peptide therapy, an emerging peptide therapy option that's gaining attention for its potential benefits in anti-aging, muscle health, and overall vitality.  Whether you've heard about it before or are learning about it for the first time, this episode will break down exactly what sermorelin is, how it works, and why some people are turning to it for a boost in...

BPC-157 is derived from a protein found in the human stomach. It promotes healing in a variety of health conditions, from muscle and tendon injuries to gut health and brain fog.  BPC-157 is available as an oral pill or an injection into the fatty tissue (subcutaneous injection) .  In this podcast, we'll discuss the differences between these two dosage forms and which may be better for you. Read th...

How fast does semaglutide work? The short answer is that many people will lose weight in the first week of taking semaglutide if they make lifestyle changes (e.g., increased physical activity and reduced-calorie diet). Remember, the first 4 doses are small and are primarily used to gently introduce the peptide to the body without risking stomach-related side effects. It's important to understand t...

Growth hormone is a protein produced by the pituitary gland in the brain. The primary job of growth hormone in childhood is to stimulate bone and tissue growth. But it's also very important in adults.  Read the Full Episode Transcript: https://pepties.com/aging-and-growth-hormone/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at B...

Tirzepatide, marketed as Zepbound, mimics the action of GLP-1 and GIP, two hormones naturally released by your gut. These hormones are critical in regulating appetite and how much food you consume. By enhancing the feeling of fullness and reducing hunger, tirzepatide helps support weight loss. Read the Full Episode Transcript: https://pepties.com/common-questions-of-tirzepatide/ Related Links/Prod...

Today we are talking about Ipamorelin and it's potential benefits.  What is Ipamorelin? Ipamorelin is a lab-made, primarily functioning as a growth hormone-releasing peptide (GHRP) or inducer. Ipamorelin works by mimicking the body's natural release of growth hormone release. It does this by increasing the number of somatotrophs (or cells responsible for growth hormone release) and it suppresses s...

Today, we're talking about how nootropics and peptides like Semax (See-max) and Selank (SEH-lank) work together to support cognitive health, improve focus, and reduce mental fatigue. Let's start with nootropics. These are substances that are designed to support and enhance mental performance. Some work by improving memory, others help with focus, alertness, or reducing brain fog. Read the Full Epi...

MK-677 also called Ibutamoren is an ORAL growth hormone-releasing peptide (GHRP) peptide therapy. We've talked about these types of peptides before when we discussed Ipamorelin. Unlike Ipamorelin it's taken by mouth and remains active for about 24 hours.  MK-677 increases growth hormone levels resulting in increased energy, lean muscle mass and strength, and improved sleep and muscle recovery.  Re...

If you're serious about real, healthy weight loss—and actually keeping your strength for the long haul—this episode is a must. We're diving into a long-overdue conversation about GLP-1 medications, metabolism, body composition, and what's really happening to your muscle mass on these meds. Because weight loss isn't just about the scale—it's about how you lose it. Let's get into it. Read the Full E...

Today we are talking about everything collagen peptides! We'll cover the benefits of collagen peptides, how to take collagen peptides, and potential side effects. Read the Full Episode Transcript: https://pepties.com/collagen-peptide-benefits/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and ent...

Today we are talking about CJC 1295 and its potential benefits. Read the Full Episode Transcript: https://pepties.com/the-power-of-cjc-1295/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevi...

Today we're talking about a peptide that gets a lot of attention in longevity circles: Epitalon. In this podcast I want to talk about what it actually is and what we really know versus what's still theoretical. Read the Full Episode Transcript: https://pepties.com/epitalon-2/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLon...

Today I want to talk about something that confuses a lot of people using tesamorelin, why food affects how it works, and how consistency over timing matters most. Read the Full Episode Transcript: https://pepties.com/tesamorelin-food-timing-and-why-consistency-actually-matters/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioL...

Today I want to talk about what actually happens in your body over time when you're on a GLP-1 peptide for weight loss. Because the reality is, nothing about these peptides works like a switch you flip on. You don't wake up one day and suddenly "stop being hungry." What actually happens is slower, more layered. Almost like your body is quietly learning a new set of rules for how it handles food, e...

Today we're tackling something that confuses so many people: why losing weight and keeping it off feels so hard. If you've ever felt like your body is working against you, like you're doing everything right but still dealing with hunger, cravings, or weight regain, this is going to make that make sense. We're going to walk through your body's set point, hunger hormones, metabolism, and something c...

Today we're talking about something that might sound a little intimidating at first—tesamorelin dosing. Don't worry—we're going to make it simple and practical.  By the end of this episode, you'll understand what tesamorelin is, how it works, and why timing your dose to match your body's natural rhythms is important for getting the best results. You'll also learn how to use it in a way that makes...

Today, we're diving into a question almost everyone asks when they start thinking about weight loss: "What's the best diet for losing weight?" And I'm going to tell you something straight away there isn't one. There's no magic plan, no secret pill or injection, no ratio of carbs to fat that guarantees fat loss for everyone. Instead, the key is understanding how your body actually works, so you can...

Today I want to talk about something that throws a lot of people off in their health and fitness journey: losing inches without seeing the scale move. It can feel confusing, but it's actually more common than most people realize. You may know the feeling. You've been working out, eating better, maybe even taking a GLP-1 medication like semaglutide or tirzepatide. Your clothes fit better, your wais...

Today, we're talking about something that can be both confusing and frustrating — why weight loss can slow down on GLP-1 medications, and how other diabetes medications, like metformin or sulfonylureas, can play a role. Read the Full Episode Transcript: https://pepties.com/why-glp-1-weight-loss-can-slow/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/...

Today we're diving into the world of NAD⁺—the different ways you can take it, and what really sets each dosage form apart. You've probably seen NAD⁺ IV drips on social media, heard about injections at wellness clinics, maybe you're already taking NR or NMN supplements, and a few weeks ago we talked about NAD⁺ patches.  But what's the real difference between all these delivery systems? Which one wo...