The Most Important Question

How many nights have you spent up recently worried that AI is just gonna take your job? That's today's big question, and my guest is Dr. Mohammed AlQuraishi. Almost three years before chatGPT and New Bing really hit the scene, Mohammed showed up to a c...

This week: Pulled in a million directions? Wondering what the hell you do with your days? Find your north stars (and become devastatingly effective) with one simple question. What We Can Do: ⚡️ Please don’t use public wifi without a VPN. Please? If you...

This week: The future of search and chatbots looks a lot like our ancient past. Why do we keep making the same tools over and over again? What We Can Do: ⚡️ Addiction is brutal. Help yourself or a loved one or someone you’ve never met with Shatterproof...

Imagine you’re in a sci-fi movie. The one where everything’s on the line. And while dinosaurs or aliens or a virus takes over down on the ground, you’re the scientist unexpectedly riding in the helicopter with the actual president, the scientist who’s ...

This week: There are a default group of problems that exist in our society because of the basic needs required to be a human. They are: Air Water Food Sleep These, our most primal needs, are more or less biologically inarguable, and the good news is, w...

This week: For the next few weeks, I’m rewriting and sharing a selection of essays I wrote in 2020 and 2021, so about two hundred years ago. I think they’re more relevant than ever — I can’t wait to hear what you think. This week: What would you say yo...

How does innovation actually work? That's today's big question, and my guest is Christopher Mims. Chris is a journalist for the Wall Street Journal, and I had him on the show in 2021 to understand how he asks big questions. Chris is constantly asking q...

This week: Everyone needs insurance. But what kind? And what does it mean to have it, or not? Well, there’s actual insurance, which is a policy where you and an insurer contract with one another in case things go south with (usually) your home, your ca...

How do we reimagine capitalism in a world on fire? That's today's big question, and my guest is Rebecca Henderson, Harvard professor behind the wildly popular class "Reimagining Capitalism". I had Rebecca on the show in 2020 to discuss her book of the ...

This week: What does it mean when people say “revolution”? For these purposes, which are pretty narrow and entirely of my own invention, I don’t mean some single moment in time, unless it was a bellwether for something bigger. And I don’t mean the revo...

How can I be a better ancestor? This question has haunted and inspired me since way back in 2019 when I first read the Optimist's Telescope. A beautiful, helpful, inspiring book by Bina Venkataraman. Then I had Bina on the show. I think it's fair to sa...

Across the front of our website, in big bold letters, is our calling card: “Science for people who give a shit.” You may have seen it and immediately thought “That’s me!” or “You sir, are a child.” Either reaction is well and great. We’re not for every...

We’re taking giving a shit quite literally this week! Our guest is Newsha Ghaeli, the president and co-founder at Biobot Analytics. If you read our newsletter, you’ll have heard me go on and on about Biobot, whose mission is to transform wastewater inf...

What’s one big change we can make that can make our food healthier, make farming more lucrative, draw down carbon in the atmosphere, and reduce climate emigration? That’s today’s big question, and my guest is Sasankh Munukutla, another fellow in our se...

Aluminum. It’s everywhere! And we’re going to need a hell of a lot more of it in the future. Aluminum is a primary ingredient in solar, wind, hydro, concentrated solar, bioenergy, the grid, batteries, hydrogen, and more. And that’s just electricity gen...

This week: Global climate news roundup beyond COP27 The human cost of vaccine inequity Water runs dry Chatbots aren't your friends Caveats to exciting AI developments Here's What You Can Do: More Democratic Senators means a greater chance the US can st...

There’s nothing quite like breaking bread with family and friends, old or new. By mid-2020, we’d have all taken the opportunity to break bread with just about anyone. Why are recipes, and the stories behind them, some of the most enduring parts of each...

It’s always worth revisiting the inarguable fact that our country was designed to be inequitable. And while much progress has been made over time, the powers that be continued to imagine and design new ways of marginalizing, at best, Black, Brown, Asia...

This week: Climate change in the curriculum Increasingly divergent subvariants Cell-cultured meat RSV vaccines are coming Generative AI (...didn't write this, but it might one day) Here's What You Can Do: Teachers can't teach without understanding the ...

Climate change is a touchy topic in farm country. But one third of greenhouse gas emissions come from food and agriculture, so it’s crucial that the industry becomes part of the climate change solution. For years almost all the action on climate change...

This week: $1 billion for electric school buses A potential "tripledemic" sandwich (not as delicious as it sounds!) One person's (treated) wastewater is another person's drinking water Most pregnancy-related deaths in America are preventable Bumble goe...

Throughout history, kings, queens, governments, churches, and donors have funded contests and awarded prizes for solving the most difficult problems of the day. Today, as we stand on the precipice of huge problems and opportunity, with everyone looking...

This week: Plant-based meat stocks Another COVID winter is coming A long-term plan for the baby formula shortage The uncertain future of telehealth Willfully shunning data privacy Here's What You Can Do: Help elect progressive state and federal candida...

Let's talk robots. But first: There’s a very particular bottleneck where groundbreaking science is more applicable than ever but inaccessible to many. The tools are unaffordable to the schools and groups who could use them to hook kids right when they’...

How lucky are we? How lucky are we that we live in a time of such great opportunity – when, yes, we’re teetering on the edge of a global climate calamity, still reeling from a pandemic, knowing that our problems and challenges are not only enormous, bu...