Dave Asprey

The Human Upgrade: Biohacking for Longevity & Performance

Health EN ↓ 1554 episodes

For more than a decade,  Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -  has redefined what’s possible for the human mind and body. After more than a thousand episodes of  Bulletproof Radio , he’s taking it to the next level with  The Human Upgrade™  - a masterclass in  biohacking, longevity, and performance optimization. Each episode explores  cutting-edge science, advanced technology, and proven biohacks  to help you  upgrade your energy, focus, metabolism, and resilience.  You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakth...

Author

Dave Asprey

Category

Health

Podcast website

daveasprey.com

Latest episode

Jul 10, 2026

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Episodes

Hacking Injury Healing from the Inside Out – Interventions With Dave – Rachelle Copeland : 1006 21.12.2022

In this Episode of The Human Upgrade™ … Dave talks with Rachelle Copeland about putting her energy into healing facial injuries and building new tissues—starting with the central nervous system. Rachelle experienced an accident that injured her face, teeth, nerves and jaw. She wants to heal quickly and avoid scarring and long-term damage while also managing the accompanying emotional trauma. This...

How Your Biomes Drive Custom Food & Supplement Solutions – Naveen Jain : 1005 16.12.2022

Viome  sponsored this episode. IN THIS EPISODE OF THE HUMAN UPGRADE™…  entrepreneur and philanthropist Naveen Jain joins the show in person at the Beverly Hilton to talk about new developments in the human biome—particularly the oral microbiome. Turns out, there may be more  density  in your gut microbiome, but there’s more  diversity  in your oral microbiome. Naveen’...

How Gut Bacteria Can Change Your Weight & Metabolism – Colleen Cutcliffe, Ph.D. : 1004 13.12.2022

Pendulum sponsored this episode. IN THIS EPISODE OF THE HUMAN UPGRADE™ …molecular biologist and biochemist Colleen Cutcliffe, Ph. D., returns to the show with brand new science about your gut. She’s a regular guest because she and her team at  Pendulum  continue to uncover innovative ways to improve your gut health, your metabolism, your immune system, how your brain works and how long y...

Why Youth Mental Health & Suicide Matters to Everyone – Dr. Mark Goulston : 1003 09.12.2022

IN THIS EPISODE OF THE HUMAN UPGRADE™ … you’ll find out that kids are killing themselves more often and at younger ages. Suicide prevention expert Dr. Mark Goulston joins the show to discuss the very real and very urgent topics of youth mental health and suicide—from pre-teens to teens to young adults. These issues concern  everyone , not only families, educators or professionals who con...

How to Do the Work, Meet Your Self and Be Your Most Authentic – Nicole LePera, Ph.D. : 1002 06.12.2022

IN THIS EPISODE OF THE HUMAN UPGRADE™ … you’ll learn about a new holistic framework for self-healing and how to heal yourself with prompts, tools and actionable tips. Using the tenants of holistic psychology, Nicole LePera, Ph. D., created a different way to reach people and equip them with the tools necessary to heal themselves. Holistic psychology focuses on the mind, body, and soul in...

Discovering Blue Zones In America – Dan Buettner : 1001 02.12.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™…  Dan Buettner  joins the show to talk about the origins and food foundations of Blue Zones. He discusses how they were discovered, what makes them different, and what’s changed for people living there over the past few decades. And the big question—is it still possible to live to 100? Dan, an explorer, National Geographic Fellow, award-winning jour...

The Bacteria That Lets You Drink Alcohol Again – Zack Abbott, Ph.D. : 1000 29.11.2022

( ZBiotics sponsored this episode.) IN THIS EPISODE OF THE HUMAN UPGRADE ™… you'll find out how to counter the sometimes rough morning after you have alcohol. The key is a new genetically engineered pre-alcohol probiotic drink. Great timing as you head into the holiday season of celebrations. Zack Abbott, CEO & co-founder of  ZBiotics , joins this 1,000th episode of the podcast...

Mini-Episode: Cool Facts Friday #29 25.11.2022

In this Episode of The Human Upgrade™...​ Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month. Sperm that swim together increase their chances of fertilization Late-night eating is worse than you thought Metabolic markers can be measured through your sweat Eye movements during REM sleep co...

How Urolithin A Helps Create Super T-Cells & Boosts Immunity – Dr. Anurag Singh : 999 22.11.2022

Timeline Nutrition  sponsored this podcast. IN THIS EPISODE OF THE HUMAN UPGRADE ™… immunologist Anurag Singh, M.D., Ph. D., MBA, Chief Medical Officer at Amazentis, joins the show to talk about urolithin A’s connection between inflammation, aging and your mitochondria.  Urolithin A activates mitophagy and renews your mitochondria.  “It takes all the cellular garbage that...

Battling Pathogens and Building Immunity Begins In Your Gut – Dr. Robynne Chutkan : 998 18.11.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™… Robynne Chutkan, M.D., joins the show to talk about a topic that’s foundational to biohacking—resilience. More specifically, resilience that starts in the gut. You’ll learn: how your microbiome continually evolves and why that matters to the state of your gut and body functions. how to strengthen the antiviral defenses located in your gut. why your body...

How Sleep Tech Improves Your Performance – Matteo Franceschetti : 997 15.11.2022

Eight Sleep  sponsored this podcast. IN THIS EPISODE OF THE HUMAN UPGRADE ™… you’ll learn about the intimate relationship between performance and sleep and how you can hack both with a combination of tech and lifestyle.  Matteo Franceschetti joins the show to talk about high performance—something he experienced in athletics, business and life. He was a competitive athlete in his nat...

Sleep Breakthroughs, Stacks & Solutions – Matt Gallant : 996 11.11.2022

BiOptimizers  sponsored this podcast. IN THIS EPISODE OF THE HUMAN UPGRADE ™… you're going to get into bed with the topic of sleep. Pretty much everyone’s favorite.  In this conversation, veteran biohacker and BiOptimers co-founder Matt Gallant returns to the show with some straight talk about how to get more and better sleep. He’s spent the big bucks—about $50K he estimates—explori...

Skincare Hacks With Meteoric Results – Andy Hnilo : 995 09.11.2022

Alitura Naturals  sponsored this podcast. IN THIS EPISODE OF THE HUMAN UPGRADE ™…… you’ll learn about skincare ingredients that can either nourish or harm your skin. You’ll find out about standards in skin care products, what “clean beauty” means, and what to look for on product labels. Andy Hnilo, founder of Alitura Naturals, joins the show to talk about skin fitness from the inside out...

Upgrade Spotlight: Calm the Chaos, Then Drink the Water – Analemma : 994 05.11.2022

Analemma sponsored this episode. IN THIS EPISODE OF THE HUMAN UPGRADE ™… you’re listening to a new Upgrade Spotlight series. Once a month, these shorter episodes feature guests who get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful ...

Sauna Big Wins: Body Detox & Depression Relief – Connie Zack : 993 03.11.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™… You’ll learn about the ways using a sauna can charge your energy, help you heal physical and mental health conditions—and science that backs that up.  Sunlighten  sponsored this episode. Connie Zack joins the show to talk about the far-reaching benefits of sauna use and what’s new in the field of infrared light. For more than 22 years, Connie...

Authentic Networking: The Give & Get Starts with Real Relationships – Joe Polish : 992 02.11.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™… Joe Polish , considered “the most connected person on the planet,” shares networking strategies that help you get what  you  want by giving people what  they  want. Dave Asprey recently connected with Joe in person to talk about Joe’s new book so you can use nine genius principles to turn your business—and your personal relationships—arou...

Mini-Episode: Cool Facts Friday #28 28.10.2022

In this Episode of The Human Upgrade™...​ Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month. • How (and why) brain cells transfer mitochondria to one another • How a newly discovered molecule stimulates hair growth • How a tired brain drives poor decision-making EPISODE SPONSOR:  Th...

Finding Your True North Through Yoga – Baron Baptiste : 991 27.10.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™… you’ll learn how a yoga practice can be a vehicle for inner transformation. This conversation looks past the popularity of yoga as a fitness trend and into its deeper potential for human development. You’ll also learn how yoga can be a way for you to explore your whole being—from physicality to emotions to thinking. “A yoga practice often can be the missing...

What Happens When You Die? On Death, Angels & Psychic Powers – Julie Ryan : 990 25.10.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™… biohacking goes in a different direction. This frank discussion looks at the dying process and how people and those close to them (family and friends) experience death. You’ll learn about the existence of angels and the power of psychic abilities—even if you may be a skeptic. The conversation also explains what a “medical intuitive” does and how a medical in...

Do You Have Cancer? A New Whole-Body MRI Scan Sees Everything – Dr. Raj Attariwala : 989 21.10.2022

Prenuvo  sponsored this episode. IN THIS EPISODE OF THE HUMAN UPGRADE ™... you’ll find out about a new healthcare model that’s putting  you  fully in control of your health with whole-body MRI scans.  Dr. Raj Attariwala,  Prenuvo ’s founding radiologist, joins the show to explain how Prenuvo gives you early insight into what’s going on under your skin. His Ph. D. in Biomed...

Menopause Bootcamp: Ditch the BS and Get to Solutions – Dr. Suzanne Gilberg-Lenz : 988 19.10.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™… menopause and the perimenopausal years leading up to it take the spotlight as a topic frequently requested by listeners. Great timing! It’s World Menopause Awareness Day Oct. 18 and World Menopause Awareness Month in October. More than  1 million women in the United States  experience menopause each year. Still, little is known, researched or taugh...

Kava: Nature’s Stress-Relieving Nootropic – Cameron George : 987 14.10.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™ ... kava expert and founder of TRU KAVA, Cameron George, joins the show to share new information about the many body/mind benefits you can get from kava. TRU KAVA sets the industry standard for kava quality, safety and education. On episodes  #731  and  #859 , we talked about kava’s historical origins and uses, how it can be safely consumed, an...

Finding Modern Medicines in the Botanical World – Cassandra Quave, Ph.D. : 986 11.10.2022

IN THIS EPISODE OF THE HUMAN UPGRADE ™… you’ll learn how botanical remedies treat infectious and inflammatory diseases. You’ll get a fascinating look at how plants and microbes interact and how antibiotic resistance evolves. And you’ll meet a leader in the field of medical botany who travels to remote locations and communities around the globe seeking out modern medicines from plants.  M...

Upgrade Spotlight: How to Use Your Breath to Stop Stress – Othership : 985 08.10.2022

Othership  sponsored this episode.   IN THIS EPISODE OF THE HUMAN UPGRADE™ …you’re listening to a new  Upgrade Spotlight  series. Once a month, these shorter episodes feature guests who get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about...

How Brain Training Changes Your Frequency – Dr. Patrick Porter : 984 07.10.2022

( BrainTap ® sponsored this episode.) IN THIS EPISODE OF THE HUMAN UPGRADE ™… brain expert  Patrick Porter, Ph. D. , joins Dave at the 8th Annual Biohacking Conference in Beverly Hills to talk about training your brain. Dr. Porter pioneered the use of brainwave entrainment with a technology-enhanced meditation device called BrainTap. Whether you’re a newbie, a hard-core de...

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