Mark Pettus MD and John Bagnulo PhD, MPH

The Health Edge: translating the science of self-care

Health EN ↓ 71 episodes

“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.  Will Rogers We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape o...

Author

Mark Pettus MD and John Bagnulo PhD, MPH

Category

Health

Latest episode

Jul 8, 2026

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Episodes

Alzheimer's and Mild Cognitive Impairment (MCI): Is this epidemic a one-way street? 01.12.2022

Send us Fan Mail Few age-related diseases are more devastating than Alzheimer's. A recent study from Columbia University suggests in individuals 65+ years of age, 10% have a dementia diagnosis and almost 25% have a diagnosis of MCI or mild cognitive decline. For the 90+ age demographic, over 30% have a dementia diagnosis. The costs to the individuals and those who care for them is staggering....

Cardiovascular Aging and Longevity 17.11.2022

Send us Fan Mail Cardiovascular disease continues to be the #1 cause of mortality in the US and around the world. In this episode of The Health Edge, Mark and John review a paper that begins to address why it is that as we age, our risk for cardiovascular disease (CVD) and all other "age-related diseases" goes up dramatically. In this 2021 paper from the Journal of The American College o...

The Omega-6 to Omega-3 Fat Ratio as a Predictor of Health and Longevity 27.10.2022

Send us Fan Mail In this recording of The Health Edge, Mark and John discuss the importance of dietary intake and sources of omega 6 and omega 3 fats. An abundance of epidemiological and clinical trials suggest high ratios of O-6/O-3 drive increased inflammation, oxidative stress and are associated with increased cardiovascular and all-cause mortality. Mark and John look at the biochemistry and so...

Saturated Fat Intake and Diabetes-Cardiovascular Risk 13.10.2022

Send us Fan Mail In this episode of The Health Edge Mark and John review some recent studies that continue to challenge the long held belief that saturated fatty acid intake (SFAs) is directly linked to diabetes and cardiometabolic risk. https://www.thelancet.com/article/S0140-6736(17)32252-3/fulltext https://pubmed.ncbi.nlm.nih.gov/36056919/

An interview with Mark Campbell PhD on the relationship between time in Nature and Health 29.09.2022

Send us Fan Mail In this recording of The Health Edge, Mark and John interview Mark Campbell PhD. We discuss the science linking time in Nature with global health outcomes. About Mark Campbell: Dr. Mark A. Campbell uses his background in wellness, sports medicine, exercise science, and performance psychology to impact change across all areas of life. His diverse background affords him the ability...

Protein Intake: How much is enough? 15.09.2022

Send us Fan Mail In this latest Health Edge video  John and Mark discuss their perspectives  on protein intake. How much? Animal versus plant?

Cardiometabolic Health: Are you a member of this exclusive club? 25.08.2022

Send us Fan Mail In this episode of The Health Edge Mark and John review a recent study published by the Journal of the American College of Cardiology, Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Mark and John reflect on how we got here and why this is so important to recognize and respond to. Lifestyle drivers and interventions are discussed that have the potent...

Fructose, Uric acid and Cardiometabolic Risk 28.07.2022

Send us Fan Mail Is it possible that consuming too much fruit could be detrimental to your health? Are all fruits the same? In this recording of The Health Edge Mark and John will explore the relationship between dietary fructose intake (from sugar and high fructose corn syrup and fruits), endogenous metabolic conversion of glucose to fructose (high glycemic foods), and high salt intake (> 5,00...

Do higher vitamin D levels slow biologic aging? 21.07.2022

Send us Fan Mail In this episode of The Health Edge Mark and John review two papers that suggest higher levels of vitamin D via supplementation may slow our biologic clocks as measured by epigenetic methylation patterns. The implications are fascinating! YouTube link:   https://youtu.be/O3UD62Pk9fE Papers reviewed: Vitamin D supplementation is associated with slower epigenetic aging https://pubmed...

Can Healthy Lifestyle Reverse Biologic Age? 08.07.2022

Send us Fan Mail In this episode of The Health Edge Mark and John review a recently published paper affirming proof of concept: healthy lifestyle may in fact reverse biologic aging or slow "biologic clocks" via epigenetic methylation patterns.  Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial https://www.ncbi.nlm.nih.gov/pmc/...

Science of Aging and Longevity Overview 22.01.2022

Send us Fan Mail In this episode of The Health Edge, Mark shares a recording from January 21, 2022 reviewing the current science of aging and longevity. This was the first of a series of 6 webinars sponsored by OLLI Berkshires. https://berkshireolli.org/ScienceOfAgingWinter22 The pdf handout from this presentation can be downloaded at www.thehealthedgepodcast.com

NAFLD: Non-Alcohol Fatty Liver Disease 27.04.2021

Send us Fan Mail In this episode of The Health Edge Mark and John review a paper demonstrating significant reductions in NAFLD with both 5:2 fasting mimicking or LCHF over just 12 weeks. Article can be found at: https://reader.elsevier.com/reader/sd/pii/S258955592100032X?token=5364332DCA18EABB9179131EF7F061F8AE705EE83CE947284A96CC9749AC9AF4E4C9FDA2D11BF95A0800388E3C0F4F6D&originRegion=us-east-...

Chronology of Insulin Resistance, Obesity and Inflammation 07.04.2021

Send us Fan Mail In this episode of The Health Edge mark and John review an important paper that suggests obesity to be more a consequence of higher insulin than a cause. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2749271

Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality 24.03.2021

Send us Fan Mail In this Health Edge podcast, John and Mark review a recent paper published in the New England Journal of Medicine that links higher intake of high-glycemic foods and beverages with higher all-cause mortality and cardiovascular disease.  https://www.nejm.org/doi/full/10.1056/NEJMoa2007123

YOUR ROADMAP TO OPTIMAL HEALTH WITH Dr. Mark Pettus 20.03.2021

Send us Fan Mail Drew Pearlman Interview:  Dr. Mark Pettus is a triple-board certified Internist, Nephrologist, and Integrative Medicine physician practicing for over 25 years.   He is also the author of two books, The Savvy Patient: The Ultimate Advocate for Quality Health Care and It’s All in Your Head: Change Your Mind, Change Your Health.  He hosts The Health Edge Podcast along side John Bagnu...

Integrative Strategies to Support Mind and Mood Health 10.03.2021

Send us Fan Mail This is a recently recorded presentation for the 2021 Physicians for Ancestral Health Symposium.

Microbiota Accessible Carbs and Health 02.03.2021

Send us Fan Mail In this videocast of The Health Edge Mark and John review some research linking higher intake of microbiota associated carbs (MAC) with biome diversity and health outcomes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143995/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896489/  

UVB Light: Why some xposure is so important for health 25.02.2021

Send us Fan Mail In this Health Edge podcast, John and Mark review a paper that reviews the many effects of UVB light on the skin and systemic neuroendocrine and immune systems. They discuss the importance of photobiomodulation and the health implications. For mind, mood, pain, and inflammation, our sophisticated skin and retinal chromophores are quantum portals to health in the presence of sunlig...

Ancestral Health: Was the advent of agriculture really a "catastrophe"? 16.02.2021

Send us Fan Mail In this Health Edge recording Mark and John review a paper by Pulitzer Prize winning journalist Jared Diamond PhD. In this paper, Dr. Diamond suggested, "The adoption of agriculture, supposedly our most decisive step toward a better life, was in many ways a catastrophe from which we have never recovered."

The Health Edge: Metabolic Flexibility 12.02.2021

Send us Fan Mail n this videocast, Mark and John review the stunningly low prevalence of metabolic health in US adults and offer some reflections on how best to improve this critical dimension of health and longevity.

The Health Edge: Metabolic Health and Flexibility 11.02.2021

Send us Fan Mail In this videocast, Mark and John review the stunningly low prevalence of metabolic health in US adults and offer some reflections on how best to improve this critical dimension of health and longevity.

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