Mark Pettus MD and John Bagnulo PhD, MPH
The Health Edge: translating the science of self-care
“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”. Will Rogers We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape o...
Author
Mark Pettus MD and John Bagnulo PhD, MPH
Category
Podcast website
Latest episode
Jul 8, 2026
Where to listen?
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Episodes
Unfiltered Coffee And Cholesterol 08.07.2026 34:23
Send us Fan Mail Cholesterol warnings have a way of flattening any nutrition story into one scary number, even when the bigger picture points the other way. We take on one of our favorite topics coffee and zoom in on the debate that keeps resurfacing: should you avoid unfiltered coffee because it contains cafestol, a compound known to raise cholesterol modestly? We break down what actually changes...
The Walking Prescription 01.07.2026 39:30
Send us Fan Mail We break down new research showing how a simple daily walking habit drives outsized gains in longevity, heart health, brain health, and mood. We also zoom out to the bigger idea that walking is not “extra credit” exercise but a basic human requirement that modern life keeps pushing out. • why small doses of movement deliver big risk reduction • what a systematic review and meta-...
What If Health Begins With A Photon 19.06.2026 59:30
Send us Fan Mail One photon travels nearly 93 million miles and still arrives with a job to do. We dig into sunlight as biology-changing information, starting with Einstein’s photoelectric effect and ending with a practical, unsettling question: what are we giving up when we spend most of life indoors and out of sync with the day? We walk through the spectrum in plain language and connect it to re...
How Bile Acids Shape Appetite Metabolism And Detox 03.06.2026 45:11
Send us Fan Mail Bile might be the most overlooked substance in everyday health, yet it sits at the crossroads of digestion, detoxification, and metabolic control. We take a fresh look at bile quality and bile acids, starting with what the liver makes from cholesterol, what the gallbladder stores, and what gets released when we eat, especially after higher fat meals. From there, the story gets far...
Sun Benefits By Using Sensible Exposure Patterns And Cleaner Sunblock 06.05.2026 47:32
Send us Fan Mail Sunscreen advice usually comes as a binary: fear the sun or ignore the risks. We take a different path and give you a practical framework for sun protection that doesn’t sacrifice the real health benefits of sunlight. From the start, we separate the roles of UVA and UVB so you can understand what actually causes sunburn, what drives vitamin D production, and why UVA is linked with...
A Practical Guide To Choosing Supplements 29.04.2026 51:48
Send us Fan Mail Your supplement shelf can turn into a silent monthly subscription, and the scariest part is not the cost. It’s the uncertainty. We sit down to unpack why supplements so often feel like a black box, how isolated nutrients can behave differently than nutrients in whole foods, and what a sensible, evidence-based supplement routine looks like when you care about real outcomes like str...
Chrononutrition And Biological Aging 17.04.2026 1:01:33
Send us Fan Mail Your body keeps time, and your fork might be one of the strongest signals it listens to. We get into chrononutrition, the growing science of meal timing, and why aligning breakfast and dinner with circadian biology may change far more than your waistline. Using a new large-cohort analysis from NHANES, we talk through how first meal time, last meal time, and the length of your dail...
A 15-Year Study Linking Unprocessed Red Meat To Lower Dementia Risk 08.04.2026 55:53
Send us Fan Mail A 15-year follow-up study out of Sweden forces an uncomfortable question: what if unprocessed red meat isn’t a brain-health villain at all, and the real risk sits upstream in metabolic dysfunction and refined carbs? Mark Pettis and John Bagnulo dig into the data on red meat consumption, cognitive decline, and dementia risk, with a special focus on the highest-concern group: people...
Fear of Skin Cancer Will Reduce Your Lifespan 01.04.2026 54:03
Send us Fan Mail Sunlight has been framed as a problem to avoid, but the data keeps pointing in the opposite direction: people who get more natural light tend to live longer and carry a lower risk of chronic disease. We take a hard look at why this topic still feels controversial, and how fear based messaging can flatten a complex risk-benefit reality into a single command: stay out of the sun. We...
How Food And Cold Exposure Can Raise Daily Calorie Burn 25.03.2026 57:40
Send us Fan Mail Thermogenesis is one of the most ignored levers in weight loss and metabolic health, and it changes the way we think about “calories out”. We talk through how your body generates heat all day long, why resting energy expenditure and basal metabolic rate are not fixed, and how small choices can compound into meaningful differences over months. We start with diet-induced thermogenes...
How Positive Age Beliefs Improve Cognitive Function And Fitness in Seniors 18.03.2026 33:46
Send us Fan Mail If you’ve ever caught yourself thinking that aging automatically means pain, weakness, or losing your independence, this conversation is a reset. We dig into a Yale study published in *Geriatrics* showing that beliefs about aging are not just “nice ideas” but measurable predictors of how well we think and move as the years pass. When you treat mindset as part of health science, th...
Statins, Muscle Mass and Strength: A long-term trade off? 11.03.2026 42:54
Send us Fan Mail What if a lower LDL comes with a quiet cost to your strength and resilience? We dig into a massive biobank analysis linking long-term statin use with declines in grip strength and appendicular lean mass, then connect the dots to sarcopenia, mitochondrial function, and the daily choices that shape metabolic health. Strength is more than performance; it predicts independence, glucos...
Pasteurized Akermansia and Metabolic Health 04.03.2026 36:03
Send us Fan Mail What if the most effective probiotic isn’t alive? We dive into the surprising science of pasteurized Akkermansia muciniphila—how a heat-treated microbe can tighten the gut barrier, steady blood sugar, and spark fat oxidation without needing to survive your stomach. Drawing on recent human trials and compelling mechanistic insights, we unpack why preserving cell-wall signals and me...
Finding The Sweet Spot For Iron And Health 04.02.2026 48:53
Send us Fan Mail Iron can be the spark for energy or the fuel for oxidative fire—and most lab reports don’t tell you which side you’re on. We dig into what really matters: tighter ferritin targets, how genetics and food shape absorption, and why the “normal range” can still mean higher risk for stroke, atherosclerosis, heart failure, and insulin resistance. We start with the fundamentals—heme vs n...
The Quality of Darkness at Night: a major disruptor of metabolic and cardiovascular health 28.01.2026 45:48
Send us Fan Mail A quiet glow at midnight can echo through your biology like a shout. We dig into new research showing that even modest night light is tied to higher risks of heart failure, atrial fibrillation, stroke, and coronary disease—and we connect the dots to circadian rhythm, metabolism, and the choices we make at home every evening. This isn’t fearmongering; it’s a roadmap for reclaiming...
Rethinking Alkaline Eating: What Really Drives Metabolic Health 14.01.2026 1:00:29
Send us Fan Mail Forget the hype about a food’s pH in your glass. What shapes your health is the acid produced after digestion—and how your kidneys manage it all day, every day. We unpack the science behind dietary acid load, explain the difference between DAL, PRAL, and NEAP, and show how a modern, grain-heavy pattern quietly raises acid burden while delivering minimal nutrients. The goal isn’t t...
Hidden Metabolic Danger In “Healthy” Adults 09.01.2026 41:55
Send us Fan Mail Feeling “fine” with normal labs can hide the earliest signs of metabolic trouble. We dive into a revealing study of young adults that compares sedentary people to those who simply meet activity guidelines, and what it uncovers inside their muscle cells is hard to ignore: lower mitochondrial respiration, poorer cardiolipin quality, higher lactate production, and a tilt toward glyco...
Uric Acid, The Hidden Metabolic Signal 31.12.2025 46:58
Send us Fan Mail A quiet lab number is telling a loud story about modern health. We dig into uric acid as a powerful signal of metabolic strain, connecting the dots between rising sugar intake, sodium overload, dehydration, and that stubborn fatigue and weight gain so many of us feel. Drawing on pioneering research from Richard Johnson and Robert Lustig, we break down how fructose doesn’t just swe...
How Exercise Intensity Shapes Longevity, Heart Health, And Metabolic Resilience 17.12.2025 53:48
Send us Fan Mail A minute that leaves you breathless can rival eight minutes of comfortable effort. That’s the eye-opening takeaway we unpack as we dive into fresh UK Biobank data showing how vigorous activity dramatically outperforms moderate and light movement for reducing all-cause mortality, cardiovascular events, diabetes, and even cancer risk. We strip away jargon and use the talk test—can y...
Coffee, AFib, And What The Science Says 11.12.2025 35:04
Send us Fan Mail Coffee and heart rhythm don’t have to be enemies. We dig into a new randomized trial across the US, Canada, and Australia suggesting that caffeinated coffee may lower the risk of recurrent atrial fibrillation compared with abstaining, then connect the dots with real-world monitoring, ablation strategy, and day-to-day choices that influence heart health. We start by grounding AFib...
The Delicate Balance Between Oxidative Stress And Antioxidants 03.12.2025 52:25
Send us Fan Mail Most wellness advice tries to stamp out oxidative stress. We make a different case: the right dose of stress is the signal that builds resilience. From the first snowfall chat to a deep dive on electrons, mitochondria, and energy flow, we walk through how redox balance—reduction and oxidation—is the unseen driver of better fitness, metabolism, and healthy aging. Rather than drowni...
How To Love Holiday Food That Loves You Back 26.11.2025 28:43
Send us Fan Mail The table can be joyful and nourishing at the same time. We open the season with a simple promise: keep the flavors you love, swap the parts that don’t love you back. From a resistant starch gravy that boosts your microbiome to a mushroom-forward, breadless stuffing that hits all the nostalgic notes, we map a path to a Thanksgiving that tastes great and leaves you energized. We re...
If Light Is A Language, What Is Your Body Hearing? 19.11.2025 49:48
Send us Fan Mail What if your lighting is sending the wrong message to your biology? We dig into the science of light as information, showing how specific wavelengths trigger opsins in the eyes and skin to set circadian rhythm, shape metabolism, and influence mood, sleep, and aging. From violet and sky-blue that kick-start morning alertness to red and near-infrared that support mitochondrial funct...
Is Coconut Oil A Villain Or Just Misunderstood? Spoiler: It’s Complicated 22.10.2025 42:56
Send us Fan Mail Curious why coconut oil can raise LDL for some people yet still show up in diets that improve metabolic health, cognition, and body composition? We get clear on what coconut oil actually is—a family of saturated fats with a rare abundance of medium-chain triglycerides—and why MCTs create ketones that the brain and mitochondria can use even without fasting. Instead of stopping at c...
Your gut can turn ellagic acid into urolithin A—and that shift may protect muscle, brain, and metabolism 15.10.2025 39:37
Send us Fan Mail If pomegranates, raspberries, and walnuts could whisper a secret to your cells, it might be this: the right microbes can turn plant defense into human resilience. We dive into the journey from ellagic acid to urolithin A, mapping how polyphenols meet the microbiome to support mitochondrial function, muscle strength, and brain health. Along the way, we unpack the science of mitopha...
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