The Big Unlock

The Big Unlock · Matthew Blosl, Chief Executive Officer, DexCare In this episode, Matthew Blosl, CEO of DexCare, discusses how he helps high-growth healthcare technology companies navigate critical inflection points by pairing disciplined focus with a culture that embraces failure as a path to innovation. He describes DexCare’s journey from a Providence Health incubated initiative to a scaled care...

The Big Unlock · Dr. Felicia Newhouse, Founder, AI-Powered Women In this episode, Dr. Felicia Newhouse, Founder of AI-Powered Women, highlights the need for human centered leadership as the foundation for AI’s future in healthcare. Reflecting on her near-death experience and two decades in tech, she warns that rapid automation may boost efficiency but often leaves people feeling overwhelmed, disco...

 The Big Unlock · Chris Gallagher, M.D., Founder and Chief Strategy Officer, Access TeleCare In this episode, Dr. Chris Gallagher, Founder and Chief Strategy Officer at Access TeleCare, shares valuable insights on the evolution of AI, how virtual care is reshaping access, staffing, and costs across health systems, and why making technology effortless is the key to driving a successful virtual-fir...

The Big Unlock · Charles E. Christian, Vice President of Technology and CTO, Franciscan Health In this episode, Charles E. Christian, VP of Technology and CTO at Franciscan Health, shares reflections from his five-decade journey in healthcare IT and how Franciscan is blending mission, compassion, and innovation to transform patient care. Chuck explains how the health system is approaching AI adopt...

The Big Unlock · Jan Beger, Global Head of AI Advocacy, GE Healthcare In this episode, Jan Beger, Global Head of AI Advocacy at GE Healthcare, shares his mission to bridge the gap between the conceptual promise and real-world impact of AI in healthcare. He stresses on the critical need to build AI literacy and trust among clinicians, executives, and students, and explains why a human-centric appro...

The Big Unlock · Thomas Fuchs, Chief AI Officer, Eli Lilly and Company In this episode, Thomas Fuchs, Chief AI Officer at Eli Lilly, shares his journey from early machine learning research to spearheading transformative AI initiatives across the pharmaceutical value chain. Lilly is running over a thousand AI projects—from drug discovery and development to manufacturing and commercial operations—le...

The Big Unlock · Dr. Girish N. Nadkarni, Chief AI Officer, Mount Sinai Health System In this episode, Dr. Girish N. Nadkarni, Chief AI Officer at Mount Sinai Health System, discusses his background as a physician-technologist and his vision for AI in healthcare as a tool that augments rather than replaces clinicians. Dr. Nadkarni shares insights on how AI is reshaping healthcare. He describes AI a...

The Big Unlock · Michael Docktor, MD, Co-founder and CEO of Dock Health In this episode, Dr. Michael Docktor, Co-founder and CEO at Dock Health, shares his journey from being a pediatric gastroenterologist at Boston Children’s Hospital to building a healthcare technology company. Inspired by his sister’s medical experiences and his family’s design background, Dr. Doctor combined medicine, design,...

The Big Unlock · Sameer Sethi, SVP, Chief AI & Insights Officer, Hackensack Meridian Health In this episode, Sameer Sethi, SVP and Chief AI & Insights Officer at Hackensack Meridian Health, shares how the health system is embedding AI directly into clinician workflows, moving from theory to real-world transformation. Sameer outlines practical applications such as specialty-specific clinica...

The Big Unlock · Ramesh Kumar, CEO and Co-Founder, zakipoint Health In this episode, Ramesh Kumar, CEO and Co-founder of Zakipoint Health, shares his perspective on addressing healthcare’s persistent challenges—high costs, lack of price transparency, and fragmented care. He emphasizes that patients, or ‘members,’ often struggle to understand the true value of care, even as regulatory pushes for tr...

The Big Unlock · Dr. Regina Druz, Founder and CEO, Holistic Heart Centers In this episode, Dr. Regina Druz, Founder and CEO at Holistic Heart Centers, shares her journey from conventional hospital-based cardiology to leading the charge in personalized precision medicine and longevity-focused care. She explains why optimizing health is the cornerstone of extending lifespan and how digital health in...

The Big Unlock · Digital Twins Could Be a Game-Changer for Scalable Healthcare Innovation – Podcast with Inderpal Kohli In this episode, Inderpal Kohli, Healthcare Executive Leader (Englewood Health, HSS, and Columbia University Medical Center), shares his vision for scalable digital health transformation. He outlines a proven framework focused on patient engagement, clinically integrated ca...

 The Big Unlock Podcast · AI If Done Right Can Rehumanize Healthcare – Podcast with Ashis Barad In this episode, Ashis Barad, Chief Digital Technology Officer at the Hospital for Special Surgery (HSS), discusses his journey in rehumanizing healthcare through digital health transformation. A practicing pediatric gastroenterologist, Ashis advocates for tech that genuinely solves problems, vie...

The Big Unlock Podcast · Interoperability and AI Adoption are the Pillars of Healthcare – Podcast with Michael Marchant In this episode, Michael Marchant, Director of Digital Applications at Sutter Health, shares his expert perspective on how interoperability and AI are reshaping the future of healthcare. He discusses the promise of TEFCA (Trusted Exchange Framework and Common Agreement) in...

The Big Unlock Podcast · Transforming Wellness-First Senior Communities Through AI and Social Determinants – Podcast with Mike Hughes In this episode, Michael Hughes, Senior EVP, Chief Transformation and Innovation Officer at United Church Homes, shares how the organization is reshaping the future of senior living. Moving beyond a traditional housing-first model, United Church Homes is leadi...

The Big Unlock Podcast · Building Value Through Real-World AI and Smart Technology Adoption – Podcast with J.D. Whitlock In this episode, J.D. Whitlock, Chief Information Officer at Dayton Children’s Hospital, discusses how a smaller pediatric health system is embracing digital transformation and generative AI while navigating resource constraints. Mr. Whitlock shares how platforms like Epic...

The Big Unlock Podcast · Aligning AI Fundamentals with User Experience in Pharma – Podcast with Alicia Abella In this episode, Alicia Abella, AI Product Lead at Novo Nordisk, discusses how she is helping drive responsible AI adoption in the pharmaceutical industry. She shares her early experiences in AI, starting with her PhD research at Columbia University on image processing and natural la...

 The Big Unlock Podcast · Designing AI-Native Healthcare with Innovation, Automation, and Responsible AI. – Podcast with Sara Vaezy In this episode, Sara Vaezy, Chief Transformation Officer at Providence, discusses Providence’s strategic approach to digital transformation, consumer engagement, and responsible AI adoption to improve both patient and caregiver experiences.  Sara highlights th...

The Big Unlock Podcast · Advancing Pulmonology with AI and Functional Imaging – Podcast with Vishisht Mehta In this episode, Dr. Vishisht Mehta, Director of Interventional Pulmonology, Comprehensive Cancer Centers of Nevada and also the Department Chair of Pulmonology at MountainView Hospital, discusses his passion for clinical practice and emerging technologies like AI and telemedicine.  Dr...

The Big Unlock Podcast · Reimagining Healthcare From Meaningful Use of Data to AI-Driven Equity – Podcast with Aneesh Chopra In this episode, Aneesh Chopra, Chief Strategy Officer at Arcadia shares a bold vision for advancing healthcare equity through smarter data use, AI, and workflow innovation. He unpacks the journey from the early days of “meaningful use” to today’s AI-powered, value-bas...

The Big Unlock Podcast · When Technology Meets Care Management, Outcomes Improve. – Podcast with Rob Posner In this episode, Rob Posner, Chief Technology Officer, AbsoluteCare discusses how the organization is transforming care delivery through a member-centric, value-based model that emphasizes advanced care management and the social determinants of health. Rob explains AbsoluteCare’s proac...

The Big Unlock Podcast · Transforming Prior Authorization with AI – Podcast with Siva Namasivayam He shares how AI is being applied to reduce administrative delays, including the use of generative AI to summarize clinical data and intelligent agents to assist with scheduling and information retrieval processes. The conversation also touches on enabling real-time approvals for a majority of c...

The Big Unlock Podcast · Scaling With Autonomous AI for Diabetic Retinopathy Screening – Podcast with Alvin Liu In this episode, Dr. T.Y. Alvin Liu, Inaugural Director, James P Gills Jr MD and Heather Gills AI Innovation Center at Johns Hopkins Medicine shares his journey in healthcare AI, with a focus on image analysis and real-world applications. Dr. Liu discusses the FDA-approved autonomo...

The Big Unlock Podcast · We Believe in Provider-led AI Where Clinicians Have the Final Say – Podcast with Patrick Mobley In this episode, Patrick Mobley, Co-Founder and CEO at Vivid Health shares how his personal background and professional journey inspired him to launch a platform that improves clinical workflows using generative AI. Built in collaboration with Redesign Health, Vivid Health...

 The Big Unlock Podcast · From Automation to Autonomy: Agentic AI Is Healthcare’s Next Frontier-Episode 163-Shekar Ramanathan In this episode, Shekar Ramanathan, Executive Director of Digital Transformation at Atlantic Health System shares how the organization is evolving from traditional automation to a future shaped by agentic AI. He shares Atlantic Health’s journey from pilot projects to scala...