The Big Unlock

The Big Unlock · Naomi Fried, PhD, Founder and CEO, PharmStars In this episode, Naomi Fried, PhD, Founder and CEO of PharmStars, shares how stronger collaboration between startups and pharmaceutical companies is accelerating healthcare innovation. Drawing on leadership roles at Biogen, Kaiser Permanente, Boston Children’s Hospital, consulting work with large pharma companies, and collaboration acr...

The Big Unlock · Dhruv Khullar, M.D., Associate Professor of Medicine and Population Health Sciences, Weill Cornell Medicine In this episode, Dr. Dhruv Khullar, Associate Professor of Medicine and Population Health Sciences at Weill Cornell Medicine, explores how technology, public trust, and the evolving role of physicians are reshaping healthcare. Drawing on his experience as both a practicing c...

The Big Unlock · Julie Demaree, VP, Chief Technology and Digital Innovation Officer, St. Mary’s Healthcare In this episode, Julie Demaree, Vice President and Chief Technology and Digital Innovation Officer at St. Mary’s Healthcare, shares a pragmatic approach to digital transformation in rural healthcare, where innovation is driven by operational realities rather than technology hype. A form...

The Big Unlock · Marshall Glanzer, Chief Technology Officer, Town Square Health In this episode, Marshall Glanzer, Chief Technology Officer of Town Square Health, outlines a bold model for scaling fully capitated risk programs for Medicare recipients. Transitioning from food-delivery logistics at GrubHub, Marshall brings critical structural insights for digital health innovators seeking to scale c...

The Big Unlock · Ben Long, MD, Director of Hospital Medicine, Magnolia Regional Health Center and Weston Blakeslee, Ph. D., VP of Clinical Intelligence, DrFirst In this episode, Dr. Ben Long, Director of Hospital Medicine at Magnolia Regional Health Center and Weston Blakeslee, VP of Clinical Intelligence at DrFirst, break down a critical industry starting point – the reality that one in fiv...

The Big Unlock · Omkar Kulkarni, VP, Chief Transformation & Innovation Officer, Children’s Hospital Los Angeles (CHLA) In this episode, Omkar Kulkarni, VP, Chief Transformation & Innovation Officer at Children’s Hospital Los Angeles (CHLA), outlines the stark funding gap in pediatric innovation, which receives less than 1% of digital health investments despite children making u...

The Big Unlock · Podcast with Dr. Nele Jessel, Chief Medical Officer, athenahealth In this episode, Dr. Nele Jessel, Chief Medical Officer at athenahealth, explores the rapid shift in physician sentiment toward AI and why healthcare may finally be reaching a true inflection point in digital transformation. Dr. Jessel explains how decades of EHR-induced administrative burnout initially made clinici...

The Big Unlock · Sally Ann Frank, Global Lead – Health & Life Sciences, Microsoft for Startups In this episode, Sally Ann Frank, Global Lead for Health and Life Sciences at Microsoft for Startups, discusses how AI is moving beyond experimentation toward measurable enterprise impact. She emphasizes that the most successful startups differentiate themselves not just through technology innovation...

The Big Unlock · Andrew Porter, CEO, Wayne General Hospital In this episode, Andrew Porter, CEO of Wayne General Hospital, shares how a community-based health system is navigating the dual pressures of financial sustainability and rural healthcare delivery. Drawing on his unique “three-legged stool” perspective as a clinician, administrator, and academic, Andrew highlights the necessit...

The Big Unlock · Bharat Sutariya, MD, Senior Vice President and Chief Health Officer, Oracle Health In this episode, Dr. Bharat Sutariya, Senior Vice President and Chief Health Officer at Oracle Health, discusses the radical transformation of healthcare through AI-native digital platforms. As an emergency physician with over 25 years of experience, including leadership roles at Cerner and Deloitte...

The Big Unlock · Linda Stevenson, Chief Operations & Information Officer, Fisher-Titus Health In this episode, Linda Stevenson, Chief Operations & Information Officer at Fisher-Titus Health, shares how rural health systems are driving innovation under significant resource constraints. Leading a 100-bed community hospital with a lean IT team, she highlights the realities of “doing more with...

The Big Unlock · Dr. Ruchi Garg, Chief Medical Officer, Fairview Park Hospital In this episode, Dr. Ruchi Garg, Chief Medical Officer at Fairview Park Hospital, shares how frontline clinicians are shaping the responsible adoption of AI in real-world care settings. Dr. Garg highlights how COVID accelerated digital adoption, from telehealth to remote patient monitoring, demonstrating that care can b...

The Big Unlock · Ed Lee, MD, MPH, Chief Medical Officer, Nabla In this episode, Dr. Ed Lee, Chief Medical Officer at Nabla, shares how AI is moving beyond hype to reshape real-world care delivery. Drawing on his experience at Kaiser Permanente, he emphasizes that the true goal of technology is not efficiency alone, but restoring the human connection in healthcare. Dr. Lee explores why change manag...

 The Big Unlock · Roy Schoenberg, M.D., CEO, Aileen and Founder and Executive Director, Amwell In this episode, Dr. Roy Schoenberg, CEO of Aileen and Founder and Executive Director of Amwell, reflects on the evolution of telehealth and shares a bold vision for AI’s role in reshaping care delivery. He argues that telehealth has largely been used as a substitute channel for traditional visits, wher...

The Big Unlock · Michael Hasselberg, PhD, RN, Chief Transformation and Digital Officer, Nebraska Medicine In this episode, Dr. Michael Hasselberg, Chief Transformation and Digital Officer at Nebraska Medicine, makes a compelling case that sustainable digital transformation in healthcare requires more than technology, it demands the right organizational structure. By unifying IT, innovation, and st...

The Big Unlock · Dr. Stephen K. Klasko, Executive in Residence, General Catalyst & Board Chair, DocGo, Teleflex In this episode, Dr. Stephen K. Klasko, former CEO of Jefferson Health, Executive in Residence at General Catalyst, Board Chair at DocGo, Teleflex, and one of healthcare’s most provocative voices, challenges the industry to rethink its fundamental assumptions and move toward a...

 The Big Unlock · Dr. Eric Stecker, Co-founder and Chief Medical Officer, Insight Health In this episode, Dr. Eric Stecker, Co-founder and Chief Medical Officer at Insight Health, explores how autonomous AI agents are reshaping cardiovascular care and population health in the United States. Dr. Stecker draws a critical distinction between autonomous action and autonomous decision-making, arguing...

The Big Unlock · Rachel Feinman, SVP of Innovation and Managing Director of TGH Ventures, Tampa General Hospital In this episode, Rachel Feinman, SVP of Innovation and Managing Director, TGH Ventures at Tampa General Hospital, shares how the organization is breaking out of “pilot purgatory” to turn digital innovation into measurable impact. With a clear mandate to move beyond endless experimentati...

The Big Unlock · Aditya Bansod, CTO & Co-Founder, Luma Health In this episode, Aditya Bansod, CTO and Co-Founder of Luma Health, about why healthcare AI often underdelivers — and what leaders must do to turn promise into performance. Aditya argues that AI’s challenge in healthcare isn’t ambition, but execution. While new tools are emerging rapidly, most remain point solutions that fail to inte...

 The Big Unlock · Dr. Andrea Willis, SVP & Chief Medical Officer, BlueCross BlueShield of Tennessee In this episode, Dr. Andrea Willis, SVP and Chief Medical Officer at BlueCross BlueShield of Tennessee, shares how payers can harness AI to advance affordable, accessible, and more human-centered care. From her clinical roots to leading population health, quality, and health equity initiatives,...

The Big Unlock · Dr. Amit Phull, Chief Clinical Experience Officer, Doximity In this episode, Dr. Amit Phull discusses what responsible AI adoption in healthcare really looks like, starting with trust, usability, and preserving clinician judgment. He emphasizes that ease of use and confidence in outputs are non-negotiable for clinician adoption, especially in already time-constrained workflows. Th...

The Big Unlock · Chethan Sathya, MD., Vice President of Strategic Initiatives, Northwell Health In this episode, Dr. Chethan Sathya, Vice President of Strategic Initiatives at Northwell Health, unpacks why healthcare innovation only scales when clinicians, public health, and AI are designed to work together. Dr. Sathya shares his journey from surgery to journalism to public health advocacy, includ...

The Big Unlock · Jonathan Bush, Founder & CEO, Zus Health In this episode, Jonathan Bush, Founder & CEO of Zus Health, shares a bold vision for the next phase of healthcare transformation. Drawing on decades of experience, Jonathan argues that while EHR adoption is largely complete, today’s systems remain fee-for-service–oriented, creating fragmented views of patients – what he descr...

The Big Unlock · Gregory Goldmacher, M.D., Associate Vice President in Clinical Research, and Head of Clinical Imaging & Pathology, Merck Research Laboratories In this episode, Dr. Greg Goldmacher, Associate VP of Clinical Research at Merck, known as MSD outside of the United States and Canada, explains how AI is transforming imaging, clinical trials, and early-stage drug development. Greg des...

The Big Unlock · Lisa Hunter, Senior Director of Federal Policy & Advocacy, United States of Care In this episode, Lisa Hunter, Senior Director of Federal Policy and Advocacy at United States of Care, discusses how her organization is working to ensure every American has access to affordable, high-quality care, with a particular focus on rural communities. She explains the new Rural Health Tra...